An inverse relation between COX-2 and E-cadherin expression correlates with aggressive histologic features in prostate cancer

Dinesh S. Rao, Dorina Gui, Michelle E. Koski, Laura M. Popoviciu, He Jing Wang, Robert E. Reiter, Jonathan W. Said

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

The identification of biomarkers in prostatic carcinoma has yielded important data regarding prognosis and has aided in increasing diagnostic accuracy. Additionally, this approach has yielded important insights into the biology of prostatic carcinoma. In this study, we report that the expression of the cyclooxygenase isoenzyme, COX-2, is significantly increased in prostatic carcinoma, whereas that of the cell adhesion molecule, E-cadherin, is decreased. The expression of COX-2 was positively correlated with higher tumor stage, and the presence of carcinoma in surgical margins at prostatectomy. Conversely, the expression of E-cadherin was inversely related to these prognostic indicators. Lastly, the expressions of COX-2 and E-cadherin were very strongly and inversely correlated. These results provide important insights into the biologic underpinnings of prostate carcinoma; and further studies into COX-2 expression in prostate core biopsies may show utility in preprostatectomy prognostication. Furthermore, these results may provide a rational basis for therapeutic intervention and chemoprevention with COX-2 inhibitor therapy in prostate carcinoma.

Original languageEnglish (US)
Pages (from-to)375-383
Number of pages9
JournalApplied Immunohistochemistry and Molecular Morphology
Volume14
Issue number4
DOIs
StatePublished - Dec 1 2006

Keywords

  • Cyclooxygenase-2 (COX-2)
  • E-cadherin
  • Prognosis
  • Prostatic adenocarcinoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology
  • Medical Laboratory Technology

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