An intramolecular 1,3-dipolar cycloaddition/electrophilic cyclization sequence to give cyclic ethers

Xenia Beebe; Cynthia L. Chiappari; Mark J. Kurth; Neil E. Schore

An intramolecular 1,3-dipolar cycloaddition/electrophilic cyclization sequence to give cyclic ethers

Xenia Beebe, Cynthia L. Chiappari, Mark J. Kurth, Neil E. Schore

Chemistry

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

An intramolecular 1,3-dipolar cycloaddition/ electrophilic cyclization sequence has been developed for the synthesis of cyclic ethers. This approach utilizes a diastereoselective nitrile oxide 1,3-dipolar cycloaddition to give furoisoxazoles, which undergo subsequent electrophilic cyclization to afford substituted tetrahydrofurans.

Original language	English (US)
Pages (from-to)	7320-7321
Number of pages	2
Journal	Journal of Organic Chemistry
Volume	58
Issue number	26
State	Published - 1993

ASJC Scopus subject areas

Organic Chemistry

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title = "An intramolecular 1,3-dipolar cycloaddition/electrophilic cyclization sequence to give cyclic ethers",

abstract = "An intramolecular 1,3-dipolar cycloaddition/ electrophilic cyclization sequence has been developed for the synthesis of cyclic ethers. This approach utilizes a diastereoselective nitrile oxide 1,3-dipolar cycloaddition to give furoisoxazoles, which undergo subsequent electrophilic cyclization to afford substituted tetrahydrofurans.",

author = "Xenia Beebe and Chiappari, {Cynthia L.} and Kurth, {Mark J.} and Schore, {Neil E.}",

year = "1993",

language = "English (US)",

volume = "58",

pages = "7320--7321",

journal = "Journal of Organic Chemistry",

issn = "0022-3263",

publisher = "American Chemical Society",

number = "26",

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T1 - An intramolecular 1,3-dipolar cycloaddition/electrophilic cyclization sequence to give cyclic ethers

AU - Beebe, Xenia

AU - Chiappari, Cynthia L.

AU - Kurth, Mark J.

AU - Schore, Neil E.

PY - 1993

Y1 - 1993

N2 - An intramolecular 1,3-dipolar cycloaddition/ electrophilic cyclization sequence has been developed for the synthesis of cyclic ethers. This approach utilizes a diastereoselective nitrile oxide 1,3-dipolar cycloaddition to give furoisoxazoles, which undergo subsequent electrophilic cyclization to afford substituted tetrahydrofurans.

AB - An intramolecular 1,3-dipolar cycloaddition/ electrophilic cyclization sequence has been developed for the synthesis of cyclic ethers. This approach utilizes a diastereoselective nitrile oxide 1,3-dipolar cycloaddition to give furoisoxazoles, which undergo subsequent electrophilic cyclization to afford substituted tetrahydrofurans.

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M3 - Article

AN - SCOPUS:0027771152

VL - 58

SP - 7320

EP - 7321

JO - Journal of Organic Chemistry

JF - Journal of Organic Chemistry

SN - 0022-3263

IS - 26

ER -

An intramolecular 1,3-dipolar cycloaddition/electrophilic cyclization sequence to give cyclic ethers

Abstract

ASJC Scopus subject areas

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