An intramolecular 1,3-dipolar cycloaddition/electrophilic cyclization sequence to give cyclic ethers

Xenia Beebe, Cynthia L. Chiappari, Mark J. Kurth, Neil E. Schore

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

An intramolecular 1,3-dipolar cycloaddition/ electrophilic cyclization sequence has been developed for the synthesis of cyclic ethers. This approach utilizes a diastereoselective nitrile oxide 1,3-dipolar cycloaddition to give furoisoxazoles, which undergo subsequent electrophilic cyclization to afford substituted tetrahydrofurans.

Original languageEnglish (US)
Pages (from-to)7320-7321
Number of pages2
JournalJournal of Organic Chemistry
Volume58
Issue number26
StatePublished - 1993

ASJC Scopus subject areas

  • Organic Chemistry

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