An intramolecular 1,3-dipolar cycloaddition/ electrophilic cyclization sequence has been developed for the synthesis of cyclic ethers. This approach utilizes a diastereoselective nitrile oxide 1,3-dipolar cycloaddition to give furoisoxazoles, which undergo subsequent electrophilic cyclization to afford substituted tetrahydrofurans.
|Original language||English (US)|
|Number of pages||2|
|Journal||Journal of Organic Chemistry|
|State||Published - 1993|
ASJC Scopus subject areas
- Organic Chemistry