An interspecies comparison of the temporomandibular joint disc

K. N. Kalpakci, V. P. Willard, M. E. Wong, K. A. Athanasiou

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

The temporomandibular joint (TMJ) disc plays a critical role in normal function of the joint, and many disorders of the TMJ are a result of disc dysfunction. Previous quantitative TMJ characterization studies examined either the human or a specific animal model, but no single study has compared different species, in the belief that differences in joint morphology, function, and diet would be reflected in the material properties of the disc. In this study, we examined topographical biochemical (collagen, glycosaminoglycan, and DNA content) and biomechanical (tensile and compressive) properties of the human TMJ disc, and also discs from the cow, goat, pig, and rabbit. Regional and interspecies variations were identified in all parameters measured, and certain disc characteristics were observed across all species, such as a weak intermediate zone under mediolateral tension. While human discs possessed properties distinct from those of the other species, pig discs were most similar to the human, suggesting that the pig may be a suitable animal model for TMJ bioengineering efforts.

Original languageEnglish (US)
Pages (from-to)193-198
Number of pages6
JournalJournal of Dental Research
Volume90
Issue number2
DOIs
StatePublished - Feb 2011

Fingerprint

Temporomandibular Joint Disc
Swine
Temporomandibular Joint
Animal Models
Joints
Bioengineering
Temporomandibular Joint Disorders
Glycosaminoglycans
Goats
Collagen
Diet
Rabbits
DNA

Keywords

  • animal model
  • interspecies
  • TMJ characterization.
  • TMJ disc

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

Kalpakci, K. N., Willard, V. P., Wong, M. E., & Athanasiou, K. A. (2011). An interspecies comparison of the temporomandibular joint disc. Journal of Dental Research, 90(2), 193-198. https://doi.org/10.1177/0022034510381501

An interspecies comparison of the temporomandibular joint disc. / Kalpakci, K. N.; Willard, V. P.; Wong, M. E.; Athanasiou, K. A.

In: Journal of Dental Research, Vol. 90, No. 2, 02.2011, p. 193-198.

Research output: Contribution to journalArticle

Kalpakci, KN, Willard, VP, Wong, ME & Athanasiou, KA 2011, 'An interspecies comparison of the temporomandibular joint disc', Journal of Dental Research, vol. 90, no. 2, pp. 193-198. https://doi.org/10.1177/0022034510381501
Kalpakci, K. N. ; Willard, V. P. ; Wong, M. E. ; Athanasiou, K. A. / An interspecies comparison of the temporomandibular joint disc. In: Journal of Dental Research. 2011 ; Vol. 90, No. 2. pp. 193-198.
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