An interlaboratory study of the pharmacokinetics of testosterone following intramuscular administration to Thoroughbred horses

Benjamin Moeller, R. A. Sams, J. Guinjab-Cagmat, N. J. Szabo, P. Colahan, Scott D Stanley

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Testosterone is an anabolic androgenic steroid (AAS) that is endogenously produced by both male and female horses that also has the potential for abuse when administered exogenously to race horses. To recommend appropriate withdrawal guidelines so that veterinarians can discontinue therapeutic use prior to competition, the pharmacokinetics and elimination of testosterone were investigated. An aqueous testosterone suspension was administered intramuscularly in the neck of Thoroughbred horses (n=20). The disposition of testosterone from this formulation was characterized by an initial, rapid absorption phase followed by a much more variable secondary absorption phase. The median terminal half-life was 39h. A second focus of this study was to compare the testosterone concentrations determined by two different laboratories using a percentage similarity model with a coefficient of variation of 16.5% showing good agreement between the two laboratories results. Based on the results of this study, a withdrawal period of 30days for aqueous testosterone administered IM is recommended.

Original languageEnglish (US)
Pages (from-to)588-593
Number of pages6
JournalJournal of Veterinary Pharmacology and Therapeutics
Volume34
Issue number6
DOIs
StatePublished - Dec 2011

Fingerprint

intramuscular injection
pharmacokinetics
Horses
testosterone
Testosterone
Pharmacokinetics
horses
Testosterone Congeners
anabolic steroids
Veterinarians
racehorses
Therapeutic Uses
neck
half life
veterinarians
Half-Life
Suspensions
Neck
water
Guidelines

ASJC Scopus subject areas

  • Pharmacology
  • veterinary(all)

Cite this

An interlaboratory study of the pharmacokinetics of testosterone following intramuscular administration to Thoroughbred horses. / Moeller, Benjamin; Sams, R. A.; Guinjab-Cagmat, J.; Szabo, N. J.; Colahan, P.; Stanley, Scott D.

In: Journal of Veterinary Pharmacology and Therapeutics, Vol. 34, No. 6, 12.2011, p. 588-593.

Research output: Contribution to journalArticle

@article{821b565528b9495ab1f27a07cac6b4a0,
title = "An interlaboratory study of the pharmacokinetics of testosterone following intramuscular administration to Thoroughbred horses",
abstract = "Testosterone is an anabolic androgenic steroid (AAS) that is endogenously produced by both male and female horses that also has the potential for abuse when administered exogenously to race horses. To recommend appropriate withdrawal guidelines so that veterinarians can discontinue therapeutic use prior to competition, the pharmacokinetics and elimination of testosterone were investigated. An aqueous testosterone suspension was administered intramuscularly in the neck of Thoroughbred horses (n=20). The disposition of testosterone from this formulation was characterized by an initial, rapid absorption phase followed by a much more variable secondary absorption phase. The median terminal half-life was 39h. A second focus of this study was to compare the testosterone concentrations determined by two different laboratories using a percentage similarity model with a coefficient of variation of 16.5{\%} showing good agreement between the two laboratories results. Based on the results of this study, a withdrawal period of 30days for aqueous testosterone administered IM is recommended.",
author = "Benjamin Moeller and Sams, {R. A.} and J. Guinjab-Cagmat and Szabo, {N. J.} and P. Colahan and Stanley, {Scott D}",
year = "2011",
month = "12",
doi = "10.1111/j.1365-2885.2011.01277.x",
language = "English (US)",
volume = "34",
pages = "588--593",
journal = "Journal of Veterinary Pharmacology and Therapeutics",
issn = "0140-7783",
publisher = "Wiley-Blackwell",
number = "6",

}

TY - JOUR

T1 - An interlaboratory study of the pharmacokinetics of testosterone following intramuscular administration to Thoroughbred horses

AU - Moeller, Benjamin

AU - Sams, R. A.

AU - Guinjab-Cagmat, J.

AU - Szabo, N. J.

AU - Colahan, P.

AU - Stanley, Scott D

PY - 2011/12

Y1 - 2011/12

N2 - Testosterone is an anabolic androgenic steroid (AAS) that is endogenously produced by both male and female horses that also has the potential for abuse when administered exogenously to race horses. To recommend appropriate withdrawal guidelines so that veterinarians can discontinue therapeutic use prior to competition, the pharmacokinetics and elimination of testosterone were investigated. An aqueous testosterone suspension was administered intramuscularly in the neck of Thoroughbred horses (n=20). The disposition of testosterone from this formulation was characterized by an initial, rapid absorption phase followed by a much more variable secondary absorption phase. The median terminal half-life was 39h. A second focus of this study was to compare the testosterone concentrations determined by two different laboratories using a percentage similarity model with a coefficient of variation of 16.5% showing good agreement between the two laboratories results. Based on the results of this study, a withdrawal period of 30days for aqueous testosterone administered IM is recommended.

AB - Testosterone is an anabolic androgenic steroid (AAS) that is endogenously produced by both male and female horses that also has the potential for abuse when administered exogenously to race horses. To recommend appropriate withdrawal guidelines so that veterinarians can discontinue therapeutic use prior to competition, the pharmacokinetics and elimination of testosterone were investigated. An aqueous testosterone suspension was administered intramuscularly in the neck of Thoroughbred horses (n=20). The disposition of testosterone from this formulation was characterized by an initial, rapid absorption phase followed by a much more variable secondary absorption phase. The median terminal half-life was 39h. A second focus of this study was to compare the testosterone concentrations determined by two different laboratories using a percentage similarity model with a coefficient of variation of 16.5% showing good agreement between the two laboratories results. Based on the results of this study, a withdrawal period of 30days for aqueous testosterone administered IM is recommended.

UR - http://www.scopus.com/inward/record.url?scp=80054104665&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80054104665&partnerID=8YFLogxK

U2 - 10.1111/j.1365-2885.2011.01277.x

DO - 10.1111/j.1365-2885.2011.01277.x

M3 - Article

C2 - 21366623

AN - SCOPUS:80054104665

VL - 34

SP - 588

EP - 593

JO - Journal of Veterinary Pharmacology and Therapeutics

JF - Journal of Veterinary Pharmacology and Therapeutics

SN - 0140-7783

IS - 6

ER -