An interface for the direct coupling of small liquid samples to AMS

T. J. Ognibene, A. T. Thomas, P. F. Daley, G. Bench, Ken W Turteltaub

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

We describe the moving wire interface attached to the 1-MV AMS system at LLNL's Center for Accelerator Mass Spectrometry for the analysis of nonvolatile liquid samples as either discrete drops or from the direct output of biochemical separatory instrumentation, such as high-performance liquid chromatography (HPLC). Discrete samples containing at least a few 10 s of nanograms of carbon and as little as 50 zmol 14C can be measured with a 3-5% precision in a few minutes. The dynamic range of our system spans approximately 3 orders in magnitude. Sample to sample memory is minimized by the use of fresh targets for each discrete sample or by minimizing the amount of carbon present in a peak generated by an HPLC containing a significant amount of 14C. Liquid sample AMS provides a new technology to expand our biomedical AMS program by enabling the capability to measure low-level biochemicals in extremely small samples that would otherwise be inaccessible.

Original languageEnglish (US)
Pages (from-to)173-177
Number of pages5
JournalNuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms
Volume361
DOIs
StatePublished - Oct 15 2015
Externally publishedYes

Fingerprint

Alpha Magnetic Spectrometer
High performance liquid chromatography
Carbon
Liquids
liquids
Particle accelerators
Mass spectrometry
Wire
Data storage equipment
liquid chromatography
carbon
dynamic range
accelerators
mass spectroscopy
wire
output

Keywords

  • C
  • Accelerator Mass Spectrometry
  • CO
  • HPLC interfaces

ASJC Scopus subject areas

  • Instrumentation
  • Nuclear and High Energy Physics

Cite this

An interface for the direct coupling of small liquid samples to AMS. / Ognibene, T. J.; Thomas, A. T.; Daley, P. F.; Bench, G.; Turteltaub, Ken W.

In: Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms, Vol. 361, 15.10.2015, p. 173-177.

Research output: Contribution to journalArticle

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