An interface for the direct coupling of small liquid samples to AMS

T. J. Ognibene; A. T. Thomas; P. F. Daley; G. Bench; Ken W Turteltaub

doi:10.1016/j.nimb.2015.05.018

An interface for the direct coupling of small liquid samples to AMS

T. J. Ognibene, A. T. Thomas, P. F. Daley, G. Bench, Ken W Turteltaub

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

We describe the moving wire interface attached to the 1-MV AMS system at LLNL's Center for Accelerator Mass Spectrometry for the analysis of nonvolatile liquid samples as either discrete drops or from the direct output of biochemical separatory instrumentation, such as high-performance liquid chromatography (HPLC). Discrete samples containing at least a few 10 s of nanograms of carbon and as little as 50 zmol ¹⁴C can be measured with a 3-5% precision in a few minutes. The dynamic range of our system spans approximately 3 orders in magnitude. Sample to sample memory is minimized by the use of fresh targets for each discrete sample or by minimizing the amount of carbon present in a peak generated by an HPLC containing a significant amount of ¹⁴C. Liquid sample AMS provides a new technology to expand our biomedical AMS program by enabling the capability to measure low-level biochemicals in extremely small samples that would otherwise be inaccessible.

Original language	English (US)
Pages (from-to)	173-177
Number of pages	5
Journal	Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms
Volume	361
DOIs	https://doi.org/10.1016/j.nimb.2015.05.018
State	Published - Oct 15 2015
Externally published	Yes

Keywords

C
Accelerator Mass Spectrometry
CO
HPLC interfaces

ASJC Scopus subject areas

Instrumentation
Nuclear and High Energy Physics

Access to Document

10.1016/j.nimb.2015.05.018

Fingerprint Dive into the research topics of 'An interface for the direct coupling of small liquid samples to AMS'. Together they form a unique fingerprint.

Cite this

@article{224442c737da47418d271b625ba01c16,

title = "An interface for the direct coupling of small liquid samples to AMS",

abstract = "We describe the moving wire interface attached to the 1-MV AMS system at LLNL's Center for Accelerator Mass Spectrometry for the analysis of nonvolatile liquid samples as either discrete drops or from the direct output of biochemical separatory instrumentation, such as high-performance liquid chromatography (HPLC). Discrete samples containing at least a few 10 s of nanograms of carbon and as little as 50 zmol 14C can be measured with a 3-5% precision in a few minutes. The dynamic range of our system spans approximately 3 orders in magnitude. Sample to sample memory is minimized by the use of fresh targets for each discrete sample or by minimizing the amount of carbon present in a peak generated by an HPLC containing a significant amount of 14C. Liquid sample AMS provides a new technology to expand our biomedical AMS program by enabling the capability to measure low-level biochemicals in extremely small samples that would otherwise be inaccessible.",

keywords = "C, Accelerator Mass Spectrometry, CO, HPLC interfaces",

author = "Ognibene, {T. J.} and Thomas, {A. T.} and Daley, {P. F.} and G. Bench and Turteltaub, {Ken W}",

year = "2015",

month = oct,

day = "15",

doi = "10.1016/j.nimb.2015.05.018",

language = "English (US)",

volume = "361",

pages = "173--177",

journal = "Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms",

issn = "0168-583X",

publisher = "Elsevier",

}

TY - JOUR

T1 - An interface for the direct coupling of small liquid samples to AMS

AU - Ognibene, T. J.

AU - Thomas, A. T.

AU - Daley, P. F.

AU - Bench, G.

AU - Turteltaub, Ken W

PY - 2015/10/15

Y1 - 2015/10/15

N2 - We describe the moving wire interface attached to the 1-MV AMS system at LLNL's Center for Accelerator Mass Spectrometry for the analysis of nonvolatile liquid samples as either discrete drops or from the direct output of biochemical separatory instrumentation, such as high-performance liquid chromatography (HPLC). Discrete samples containing at least a few 10 s of nanograms of carbon and as little as 50 zmol 14C can be measured with a 3-5% precision in a few minutes. The dynamic range of our system spans approximately 3 orders in magnitude. Sample to sample memory is minimized by the use of fresh targets for each discrete sample or by minimizing the amount of carbon present in a peak generated by an HPLC containing a significant amount of 14C. Liquid sample AMS provides a new technology to expand our biomedical AMS program by enabling the capability to measure low-level biochemicals in extremely small samples that would otherwise be inaccessible.

AB - We describe the moving wire interface attached to the 1-MV AMS system at LLNL's Center for Accelerator Mass Spectrometry for the analysis of nonvolatile liquid samples as either discrete drops or from the direct output of biochemical separatory instrumentation, such as high-performance liquid chromatography (HPLC). Discrete samples containing at least a few 10 s of nanograms of carbon and as little as 50 zmol 14C can be measured with a 3-5% precision in a few minutes. The dynamic range of our system spans approximately 3 orders in magnitude. Sample to sample memory is minimized by the use of fresh targets for each discrete sample or by minimizing the amount of carbon present in a peak generated by an HPLC containing a significant amount of 14C. Liquid sample AMS provides a new technology to expand our biomedical AMS program by enabling the capability to measure low-level biochemicals in extremely small samples that would otherwise be inaccessible.

KW - C

KW - Accelerator Mass Spectrometry

KW - CO

KW - HPLC interfaces

UR - http://www.scopus.com/inward/record.url?scp=84943584285&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84943584285&partnerID=8YFLogxK

U2 - 10.1016/j.nimb.2015.05.018

DO - 10.1016/j.nimb.2015.05.018

M3 - Article

AN - SCOPUS:84943584285

VL - 361

SP - 173

EP - 177

JO - Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms

JF - Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms

SN - 0168-583X

ER -

An interface for the direct coupling of small liquid samples to AMS

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Cite this