An improved model of Ba current through L-type Ca channels including voltage- and ion-dependent inactivation

S. Morotti, Eleonora Grandi, A. Summa, Kenneth S Ginsburg, Donald M Bers, S. Severi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The substitution of Ba ions for Ca has been widely used to separate voltage-dependent inactivation (VDI) from Ca-dependent inactivation (CDI) of the Ca current (ICa) through L-type Ca channels (LTCCs). However, a modest ion-dependent inactivation of Ba current (IBa) has been shown experimentally. We have incorporated the Mahajan et al. Markov model of LTCC, which describes IBa inactivation as VDI only, into the Shannon et al excitation-contraction coupling model. We extended the LTCC model to assess whether and how experimental IBa inactivation could be recapitulated by modifying CDI. Simulation results show that IBa inactivation measured in rabbit myocytes at physiological temperature can be recapitulated when making the Ca-dependent transition rates 10-fold less sensitive to Ba vs. Ca. Our extended LTCC model provides a more faithful representation of purely VDI during ICa.

Original languageEnglish (US)
Title of host publicationComputing in Cardiology
Pages645-648
Number of pages4
Volume37
StatePublished - 2010
EventComputing in Cardiology 2010, CinC 2010 - Belfast, United Kingdom
Duration: Sep 26 2010Sep 29 2010

Other

OtherComputing in Cardiology 2010, CinC 2010
CountryUnited Kingdom
CityBelfast
Period9/26/109/29/10

ASJC Scopus subject areas

  • Computer Science Applications
  • Cardiology and Cardiovascular Medicine

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    Morotti, S., Grandi, E., Summa, A., Ginsburg, K. S., Bers, D. M., & Severi, S. (2010). An improved model of Ba current through L-type Ca channels including voltage- and ion-dependent inactivation. In Computing in Cardiology (Vol. 37, pp. 645-648). [5738055]