Abstract
The substitution of Ba ions for Ca has been widely used to separate voltage-dependent inactivation (VDI) from Ca-dependent inactivation (CDI) of the Ca current (ICa) through L-type Ca channels (LTCCs). However, a modest ion-dependent inactivation of Ba current (IBa) has been shown experimentally. We have incorporated the Mahajan et al. Markov model of LTCC, which describes IBa inactivation as VDI only, into the Shannon et al excitation-contraction coupling model. We extended the LTCC model to assess whether and how experimental IBa inactivation could be recapitulated by modifying CDI. Simulation results show that IBa inactivation measured in rabbit myocytes at physiological temperature can be recapitulated when making the Ca-dependent transition rates 10-fold less sensitive to Ba vs. Ca. Our extended LTCC model provides a more faithful representation of purely VDI during ICa.
Original language | English (US) |
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Title of host publication | Computing in Cardiology |
Pages | 645-648 |
Number of pages | 4 |
Volume | 37 |
State | Published - 2010 |
Event | Computing in Cardiology 2010, CinC 2010 - Belfast, United Kingdom Duration: Sep 26 2010 → Sep 29 2010 |
Other
Other | Computing in Cardiology 2010, CinC 2010 |
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Country | United Kingdom |
City | Belfast |
Period | 9/26/10 → 9/29/10 |
ASJC Scopus subject areas
- Computer Science Applications
- Cardiology and Cardiovascular Medicine