An immunopathologic evaluation of lymph nodes from monkey and man with acquired immune deficiency syndrome and related conditions

P. R. Meyer, L. D. Ormerod, K. G. Osborn, Linda J Lowenstine, R. V. Hendrickson, R. L. Modlin, R. E. Smith, M. B. Gardner, C. R. Taylor

Research output: Contribution to journalArticle

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Abstract

Morphology and immunostaining of lymph nodes taken from rhesus monkeys and man are compared. The monkeys were inoculated with biologic materials known to transmit simian acquired immune deficiency syndrome (SAIDS) and the human biopsies were obtained from homosexual men with persistent generalized lymphadenopathy syndrome or acquired immune deficiency syndrome (AIDS). The lymph nodes from monkey and man share common immunohistochemical features, ranging from exhuberant follicular hyperplasia to lymphocyte depletion stage. The follicular hyperplasia differed from reactive controls by the larger follicular size and disorganization within the follicular centers as well as an increase in the number of cells with the T suppressor/cytotoxic phenotype. The lymphocyte depletion stage showed a loss of reactive follicles and small T lymphocytes with a predominance of mature monocytes/macrophages. Most monkeys and humans with the lymphocyte depletion morphology fulfilled the case definitions for AIDS and SAIDS while those with follicular hyperplasia usually had 'prodromal' findings. The simian agent is associated with alterations in lymph node morphology and immunostaining which parallel the changes seen in spontaneous human cases supporting a similar pathogenesis for AIDS and SAIDS.

Original languageEnglish (US)
Pages (from-to)199-210
Number of pages12
JournalHematological Oncology
Volume3
Issue number3
DOIs
StatePublished - 1985

Fingerprint

Simian Acquired Immunodeficiency Syndrome
Lymphocyte Depletion
Hyperplasia
Haplorhini
Acquired Immunodeficiency Syndrome
Lymph Nodes
AIDS-Related Complex
Macaca mulatta
Monocytes
Cell Count
Macrophages
T-Lymphocytes
Phenotype
Biopsy

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Cite this

An immunopathologic evaluation of lymph nodes from monkey and man with acquired immune deficiency syndrome and related conditions. / Meyer, P. R.; Ormerod, L. D.; Osborn, K. G.; Lowenstine, Linda J; Hendrickson, R. V.; Modlin, R. L.; Smith, R. E.; Gardner, M. B.; Taylor, C. R.

In: Hematological Oncology, Vol. 3, No. 3, 1985, p. 199-210.

Research output: Contribution to journalArticle

Meyer, PR, Ormerod, LD, Osborn, KG, Lowenstine, LJ, Hendrickson, RV, Modlin, RL, Smith, RE, Gardner, MB & Taylor, CR 1985, 'An immunopathologic evaluation of lymph nodes from monkey and man with acquired immune deficiency syndrome and related conditions', Hematological Oncology, vol. 3, no. 3, pp. 199-210. https://doi.org/10.1002/hon.2900030308
Meyer, P. R. ; Ormerod, L. D. ; Osborn, K. G. ; Lowenstine, Linda J ; Hendrickson, R. V. ; Modlin, R. L. ; Smith, R. E. ; Gardner, M. B. ; Taylor, C. R. / An immunopathologic evaluation of lymph nodes from monkey and man with acquired immune deficiency syndrome and related conditions. In: Hematological Oncology. 1985 ; Vol. 3, No. 3. pp. 199-210.
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