An fMRI study of facial emotion processing in patients with schizophrenia

Raquel E. Gur, Claire McGrath, Robin M. Chan, Lee Schroeder, Travis Turner, Bruce I. Turetsky, Christian Kohler, David Alsop, Joseph Maldjian, John D Ragland, Ruben C. Gur

Research output: Contribution to journalArticle

368 Citations (Scopus)

Abstract

Objective: Emotion processing deficits are notable in schizophrenia. The authors evaluated cerebral blood flow response in schizophrenia patients during facial emotion processing to test the hypothesis of diminished limbic activation related to emotional relevance of facial stimuli. Method: Fourteen patients with schizophrenia and 14 matched comparison subjects viewed facial displays of happiness, sadness, anger, fear, and disgust as well as neutral faces. Functional magnetic resonance imaging was used to measure blood-oxygen-level-dependent signal changes as the subjects alternated between tasks of discriminating emotional valence (positive versus negative) and age (over 30 versus under 30) of the faces with an interleaved crosshair reference condition. Results: The groups did not differ in performance on either task. For both tasks, healthy participants showed activation in the fusiform gyrus, occipital lobe, and inferior frontal cortex relative to the resting baseline condition. The increase was greater in the amygdala and hippocampus during the emotional valence discrimination task than during the age discrimination task. In the patients with schizophrenia, minimal focal response was observed for all tasks relative to the resting baseline condition. Contrasting patients and comparison subjects on the emotional valence discrimination task revealed voxels in the left amygdala and bilateral hippocampus in which the comparison subjects had significantly greater activation. Conclusions: Failure to activate limbic regions during emotional valence discrimination may explain emotion processing deficits in patients with schizophrenia. While the lack of limbic recruitment did not significantly impair simple valence discrimination performance in this clinically stable group, it may impact performance of more demanding tasks.

Original languageEnglish (US)
Pages (from-to)1992-1999
Number of pages8
JournalAmerican Journal of Psychiatry
Volume159
Issue number12
DOIs
StatePublished - Dec 1 2002
Externally publishedYes

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Schizophrenia
Emotions
Magnetic Resonance Imaging
Amygdala
Hippocampus
Cerebrovascular Circulation
Ageism
Occipital Lobe
Happiness
Anger
Frontal Lobe
Temporal Lobe
Fear
Healthy Volunteers
Oxygen

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Gur, R. E., McGrath, C., Chan, R. M., Schroeder, L., Turner, T., Turetsky, B. I., ... Gur, R. C. (2002). An fMRI study of facial emotion processing in patients with schizophrenia. American Journal of Psychiatry, 159(12), 1992-1999. https://doi.org/10.1176/appi.ajp.159.12.1992

An fMRI study of facial emotion processing in patients with schizophrenia. / Gur, Raquel E.; McGrath, Claire; Chan, Robin M.; Schroeder, Lee; Turner, Travis; Turetsky, Bruce I.; Kohler, Christian; Alsop, David; Maldjian, Joseph; Ragland, John D; Gur, Ruben C.

In: American Journal of Psychiatry, Vol. 159, No. 12, 01.12.2002, p. 1992-1999.

Research output: Contribution to journalArticle

Gur, RE, McGrath, C, Chan, RM, Schroeder, L, Turner, T, Turetsky, BI, Kohler, C, Alsop, D, Maldjian, J, Ragland, JD & Gur, RC 2002, 'An fMRI study of facial emotion processing in patients with schizophrenia', American Journal of Psychiatry, vol. 159, no. 12, pp. 1992-1999. https://doi.org/10.1176/appi.ajp.159.12.1992
Gur RE, McGrath C, Chan RM, Schroeder L, Turner T, Turetsky BI et al. An fMRI study of facial emotion processing in patients with schizophrenia. American Journal of Psychiatry. 2002 Dec 1;159(12):1992-1999. https://doi.org/10.1176/appi.ajp.159.12.1992
Gur, Raquel E. ; McGrath, Claire ; Chan, Robin M. ; Schroeder, Lee ; Turner, Travis ; Turetsky, Bruce I. ; Kohler, Christian ; Alsop, David ; Maldjian, Joseph ; Ragland, John D ; Gur, Ruben C. / An fMRI study of facial emotion processing in patients with schizophrenia. In: American Journal of Psychiatry. 2002 ; Vol. 159, No. 12. pp. 1992-1999.
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