TY - JOUR
T1 - An experimental, virus-induced retinal dysplasia in the fetal lamb
AU - Silverstein, Arthur M.
AU - Parshall, Charles J.
AU - Osburn, Bennie
AU - Prendergast, Robert A.
PY - 1971/1/1
Y1 - 1971/1/1
N2 - Retinal dysplasia, accompanying extensive destructive retinopathy and hydranencephaly, has been produced in the fetal lamb with the attenuated bluetongue virus, a livevirus vaccine nonpathogenic in adult sheep. With increasing maturity, the nature of the ocular disease changes in the fetus, until late in gestation it demonstrates a typical adult resistance to the viral agent. Some of the host factors which may modulate the apparent pathogenicity of infectious agents have been discussed, along with some of the maturational events which may account for the increased resistance of the older fetus and adult to this viral agent.
AB - Retinal dysplasia, accompanying extensive destructive retinopathy and hydranencephaly, has been produced in the fetal lamb with the attenuated bluetongue virus, a livevirus vaccine nonpathogenic in adult sheep. With increasing maturity, the nature of the ocular disease changes in the fetus, until late in gestation it demonstrates a typical adult resistance to the viral agent. Some of the host factors which may modulate the apparent pathogenicity of infectious agents have been discussed, along with some of the maturational events which may account for the increased resistance of the older fetus and adult to this viral agent.
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U2 - 10.1016/0002-9394(71)91587-X
DO - 10.1016/0002-9394(71)91587-X
M3 - Article
AN - SCOPUS:0343652081
VL - 72
SP - 22
EP - 34
JO - American Journal of Ophthalmology
JF - American Journal of Ophthalmology
SN - 0002-9394
IS - 1
ER -