Abstract
Retinal dysplasia, accompanying extensive destructive retinopathy and hydranencephaly, has been produced in the fetal lamb with the attenuated bluetongue virus, a livevirus vaccine nonpathogenic in adult sheep. With increasing maturity, the nature of the ocular disease changes in the fetus, until late in gestation it demonstrates a typical adult resistance to the viral agent. Some of the host factors which may modulate the apparent pathogenicity of infectious agents have been discussed, along with some of the maturational events which may account for the increased resistance of the older fetus and adult to this viral agent.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 22-34 |
| Number of pages | 13 |
| Journal | American Journal of Ophthalmology |
| Volume | 72 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 1971 |
| Externally published | Yes |
ASJC Scopus subject areas
- Ophthalmology
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Cite this
Silverstein, A. M., Parshall, C. J., Osburn, B., & Prendergast, R. A. (1971). An experimental, virus-induced retinal dysplasia in the fetal lamb. American Journal of Ophthalmology, 72(1), 22-34. https://doi.org/10.1016/0002-9394(71)91587-X