An experimental, virus-induced retinal dysplasia in the fetal lamb

Arthur M. Silverstein, Charles J. Parshall, Bennie Osburn, Robert A. Prendergast

Research output: Contribution to journalArticlepeer-review

38 Scopus citations


Retinal dysplasia, accompanying extensive destructive retinopathy and hydranencephaly, has been produced in the fetal lamb with the attenuated bluetongue virus, a livevirus vaccine nonpathogenic in adult sheep. With increasing maturity, the nature of the ocular disease changes in the fetus, until late in gestation it demonstrates a typical adult resistance to the viral agent. Some of the host factors which may modulate the apparent pathogenicity of infectious agents have been discussed, along with some of the maturational events which may account for the increased resistance of the older fetus and adult to this viral agent.

Original languageEnglish (US)
Pages (from-to)22-34
Number of pages13
JournalAmerican Journal of Ophthalmology
Issue number1
StatePublished - Jan 1 1971
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology


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