An experimental model of vasovagal syncope induces cerebral hypoperfusion and fainting-like behavior in awake rats

Devin W. McBride, Cesar Reis, Ethan Frank, Damon W. Klebe, John H. Zhang, Richard Lee Applegate, Jiping Tang

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Vasovagal syncope, a contributing factor to elderly falls, is the transient loss of consciousness caused by decreased cerebral perfusion. Vasovagal syncope is characterized by hypotension, bradycardia, and reduced cerebral blood flow, resulting in fatigue, altered coordination, and fainting. The purpose of this study is to develop an animal model which is similar to human vasovagal syncope and establish an awake animal model of vasovagal syncope. Male Sprague-Dawley rats were subjected to sinusoidal galvanic vestibular stimulation (sGVS). Blood pressure, heart rate, and cerebral blood flow were monitored before, during, and post-stimulation. sGVS resulted in hypotension, bradycardia, and decreased cerebral blood flow. One cohort of animals was subjected to sGVS while freely moving. sGVS in awake animals produced vasovagal syncope-like symptoms, including fatigue and uncoordinated movements; two animals experienced spontaneous falling. Another cohort of animals was preconditioned with isoflurane for several days before being subjected to sGVS. Isoflurane preconditioning before sGVS did not prevent sGVS-induced hypotension or bradycardia, yet isoflurane preconditioning attenuated sGVS-induced cerebral blood flow reduction. The sGVS rat model mimics elements of human vasovagal syncope pathophysiology (hypotension, bradycardia, and decreased cerebral perfusion), including behavioral symptoms such as fatigue and altered balance. This study indicates that the sGVS rat model is similar to human vasovagal syncope and that therapies directed at preventing cerebral hypoperfusion may decrease syncopal episodes and reduce injuries from syncopal falls.

Original languageEnglish (US)
Article numbere0163280
JournalPLoS One
Volume11
Issue number9
DOIs
StatePublished - Sep 1 2016
Externally publishedYes

Fingerprint

syncope
Vasovagal Syncope
Syncope
Cerebrovascular Circulation
Rats
Animals
Theoretical Models
Bradycardia
Isoflurane
hypotension
rats
Blood
blood flow
isoflurane
Hypotension
Fatigue
animal models
Fatigue of materials
signs and symptoms (animals and humans)
Accidental Falls

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

An experimental model of vasovagal syncope induces cerebral hypoperfusion and fainting-like behavior in awake rats. / McBride, Devin W.; Reis, Cesar; Frank, Ethan; Klebe, Damon W.; Zhang, John H.; Applegate, Richard Lee; Tang, Jiping.

In: PLoS One, Vol. 11, No. 9, e0163280, 01.09.2016.

Research output: Contribution to journalArticle

McBride, Devin W. ; Reis, Cesar ; Frank, Ethan ; Klebe, Damon W. ; Zhang, John H. ; Applegate, Richard Lee ; Tang, Jiping. / An experimental model of vasovagal syncope induces cerebral hypoperfusion and fainting-like behavior in awake rats. In: PLoS One. 2016 ; Vol. 11, No. 9.
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