An experimental model of ectropion uveae and iris neovascularization in the cat

Leonard M Hjelmeland; M. W. Stewart; J. Li; C. A. Toth; M. S. Burns; M. B. Landers

An experimental model of ectropion uveae and iris neovascularization in the cat

Leonard M Hjelmeland, M. W. Stewart, J. Li, C. A. Toth, M. S. Burns, M. B. Landers

Ophthalmology and Vision Science

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Neovascularization of the iris (NVI) is one of the most frequently studied intraocular vascular proliferations in animal models. Ectropion uveae has not been a consistent finding in these studies. In this study, a surgical model of ectropion uveae and iris neovascularization was developed that involved lensectomy, vitrectomy, bipolar cautery and transection of all three principal branch veins in the cat eye. Twelve of 14 eyes that received this procedure developed postoperative retinal detachments with a clinical picture of hemorrhagic retinopathy. These eyes progressed to a clinical picture of NVI within 1-7 wk. Eight eyes developed ectropion uveae for as much as 300°. At the light microscopic level, a fibrovascular membrane was apparent on the anterior iris stroma in 9 of 14 eyes and further involved the angle in six eyes.

Original language	English (US)
Pages (from-to)	1796-1803
Number of pages	8
Journal	Investigative Ophthalmology and Visual Science
Volume	33
Issue number	5
State	Published - 1992

Keywords

animal model
ectropion uveae
iris neovascularization

ASJC Scopus subject areas

Ophthalmology

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title = "An experimental model of ectropion uveae and iris neovascularization in the cat",

abstract = "Neovascularization of the iris (NVI) is one of the most frequently studied intraocular vascular proliferations in animal models. Ectropion uveae has not been a consistent finding in these studies. In this study, a surgical model of ectropion uveae and iris neovascularization was developed that involved lensectomy, vitrectomy, bipolar cautery and transection of all three principal branch veins in the cat eye. Twelve of 14 eyes that received this procedure developed postoperative retinal detachments with a clinical picture of hemorrhagic retinopathy. These eyes progressed to a clinical picture of NVI within 1-7 wk. Eight eyes developed ectropion uveae for as much as 300°. At the light microscopic level, a fibrovascular membrane was apparent on the anterior iris stroma in 9 of 14 eyes and further involved the angle in six eyes.",

keywords = "animal model, ectropion uveae, iris neovascularization",

author = "Hjelmeland, {Leonard M} and Stewart, {M. W.} and J. Li and Toth, {C. A.} and Burns, {M. S.} and Landers, {M. B.}",

year = "1992",

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T1 - An experimental model of ectropion uveae and iris neovascularization in the cat

AU - Hjelmeland, Leonard M

AU - Stewart, M. W.

AU - Li, J.

AU - Toth, C. A.

AU - Burns, M. S.

AU - Landers, M. B.

PY - 1992

Y1 - 1992

N2 - Neovascularization of the iris (NVI) is one of the most frequently studied intraocular vascular proliferations in animal models. Ectropion uveae has not been a consistent finding in these studies. In this study, a surgical model of ectropion uveae and iris neovascularization was developed that involved lensectomy, vitrectomy, bipolar cautery and transection of all three principal branch veins in the cat eye. Twelve of 14 eyes that received this procedure developed postoperative retinal detachments with a clinical picture of hemorrhagic retinopathy. These eyes progressed to a clinical picture of NVI within 1-7 wk. Eight eyes developed ectropion uveae for as much as 300°. At the light microscopic level, a fibrovascular membrane was apparent on the anterior iris stroma in 9 of 14 eyes and further involved the angle in six eyes.

AB - Neovascularization of the iris (NVI) is one of the most frequently studied intraocular vascular proliferations in animal models. Ectropion uveae has not been a consistent finding in these studies. In this study, a surgical model of ectropion uveae and iris neovascularization was developed that involved lensectomy, vitrectomy, bipolar cautery and transection of all three principal branch veins in the cat eye. Twelve of 14 eyes that received this procedure developed postoperative retinal detachments with a clinical picture of hemorrhagic retinopathy. These eyes progressed to a clinical picture of NVI within 1-7 wk. Eight eyes developed ectropion uveae for as much as 300°. At the light microscopic level, a fibrovascular membrane was apparent on the anterior iris stroma in 9 of 14 eyes and further involved the angle in six eyes.

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