Abstract
Neovascularization of the iris (NVI) is one of the most frequently studied intraocular vascular proliferations in animal models. Ectropion uveae has not been a consistent finding in these studies. In this study, a surgical model of ectropion uveae and iris neovascularization was developed that involved lensectomy, vitrectomy, bipolar cautery and transection of all three principal branch veins in the cat eye. Twelve of 14 eyes that received this procedure developed postoperative retinal detachments with a clinical picture of hemorrhagic retinopathy. These eyes progressed to a clinical picture of NVI within 1-7 wk. Eight eyes developed ectropion uveae for as much as 300°. At the light microscopic level, a fibrovascular membrane was apparent on the anterior iris stroma in 9 of 14 eyes and further involved the angle in six eyes.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1796-1803 |
| Number of pages | 8 |
| Journal | Investigative Ophthalmology and Visual Science |
| Volume | 33 |
| Issue number | 5 |
| State | Published - 1992 |
Fingerprint
Keywords
- animal model
- ectropion uveae
- iris neovascularization
ASJC Scopus subject areas
- Ophthalmology
Cite this
An experimental model of ectropion uveae and iris neovascularization in the cat. / Hjelmeland, Leonard M; Stewart, M. W.; Li, J.; Toth, C. A.; Burns, M. S.; Landers, M. B.
In: Investigative Ophthalmology and Visual Science, Vol. 33, No. 5, 1992, p. 1796-1803.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - An experimental model of ectropion uveae and iris neovascularization in the cat
AU - Hjelmeland, Leonard M
AU - Stewart, M. W.
AU - Li, J.
AU - Toth, C. A.
AU - Burns, M. S.
AU - Landers, M. B.
PY - 1992
Y1 - 1992
N2 - Neovascularization of the iris (NVI) is one of the most frequently studied intraocular vascular proliferations in animal models. Ectropion uveae has not been a consistent finding in these studies. In this study, a surgical model of ectropion uveae and iris neovascularization was developed that involved lensectomy, vitrectomy, bipolar cautery and transection of all three principal branch veins in the cat eye. Twelve of 14 eyes that received this procedure developed postoperative retinal detachments with a clinical picture of hemorrhagic retinopathy. These eyes progressed to a clinical picture of NVI within 1-7 wk. Eight eyes developed ectropion uveae for as much as 300°. At the light microscopic level, a fibrovascular membrane was apparent on the anterior iris stroma in 9 of 14 eyes and further involved the angle in six eyes.
AB - Neovascularization of the iris (NVI) is one of the most frequently studied intraocular vascular proliferations in animal models. Ectropion uveae has not been a consistent finding in these studies. In this study, a surgical model of ectropion uveae and iris neovascularization was developed that involved lensectomy, vitrectomy, bipolar cautery and transection of all three principal branch veins in the cat eye. Twelve of 14 eyes that received this procedure developed postoperative retinal detachments with a clinical picture of hemorrhagic retinopathy. These eyes progressed to a clinical picture of NVI within 1-7 wk. Eight eyes developed ectropion uveae for as much as 300°. At the light microscopic level, a fibrovascular membrane was apparent on the anterior iris stroma in 9 of 14 eyes and further involved the angle in six eyes.
KW - animal model
KW - ectropion uveae
KW - iris neovascularization
UR - http://www.scopus.com/inward/record.url?scp=0026552701&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026552701&partnerID=8YFLogxK
M3 - Article
C2 - 1373124
AN - SCOPUS:0026552701
VL - 33
SP - 1796
EP - 1803
JO - Investigative Ophthalmology and Visual Science
JF - Investigative Ophthalmology and Visual Science
SN - 0146-0404
IS - 5
ER -