An experimental model of ectropion uveae and iris neovascularization in the cat

Leonard M Hjelmeland, M. W. Stewart, J. Li, C. A. Toth, M. S. Burns, M. B. Landers

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Neovascularization of the iris (NVI) is one of the most frequently studied intraocular vascular proliferations in animal models. Ectropion uveae has not been a consistent finding in these studies. In this study, a surgical model of ectropion uveae and iris neovascularization was developed that involved lensectomy, vitrectomy, bipolar cautery and transection of all three principal branch veins in the cat eye. Twelve of 14 eyes that received this procedure developed postoperative retinal detachments with a clinical picture of hemorrhagic retinopathy. These eyes progressed to a clinical picture of NVI within 1-7 wk. Eight eyes developed ectropion uveae for as much as 300°. At the light microscopic level, a fibrovascular membrane was apparent on the anterior iris stroma in 9 of 14 eyes and further involved the angle in six eyes.

Original languageEnglish (US)
Pages (from-to)1796-1803
Number of pages8
JournalInvestigative Ophthalmology and Visual Science
Volume33
Issue number5
StatePublished - 1992

Keywords

  • animal model
  • ectropion uveae
  • iris neovascularization

ASJC Scopus subject areas

  • Ophthalmology

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    Hjelmeland, L. M., Stewart, M. W., Li, J., Toth, C. A., Burns, M. S., & Landers, M. B. (1992). An experimental model of ectropion uveae and iris neovascularization in the cat. Investigative Ophthalmology and Visual Science, 33(5), 1796-1803.