An evaluation of exact and approximate 3-D reconstruction algorithms for a high- resolution, small-animal PET scanner

T. H. Farquhar, A. Chatziioannou, Simon R Cherry

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

MicroPET is a low-cost, high-resolution positron emission tomography (PET) scanner designed for imaging small animals. MicroPET operates exclusively without septa, acquiring fully three-dimensional (3-D) data sets. The performance of the projection-reprojection (3DRP), variable axial rebinning (VARB), single slice rebinning (SSRB), and Fourier rebinning (FORE) methods for reconstruction of microPET data were evaluated. The algorithms were compared with respect to resolution, noise variance, and reconstruction time. Results suggested that the 3DRP algorithm gives the best combination of resolution and noise performance in 9 min of reconstruction time on a Sun UltraSparc I workstation. The FORE algorithm provided the most acceptable accelerated method of reconstruction, giving similar resolution performance with a 10%-20% degradation in noise variance in under 2 min. Significant degradation in the axial resolution was measured with the VARB and SSRB methods, offsetting the decrease in reconstruction time achieved with those methods. In-plane angular mashing of the 3-D data before reconstruction led to a 50% reduction in reconstruction time but also introduced unacceptable tangential blurring artifacts. This thorough evaluation of analytical 3-D reconstruction techniques allowed for optimal selection of a reconstruction method for the diverse range of microPET applications.

Original languageEnglish (US)
Pages (from-to)1073-1080
Number of pages8
JournalIEEE Transactions on Medical Imaging
Volume17
Issue number6
StatePublished - 1998

Fingerprint

Positron emission tomography
Positron-Emission Tomography
Animals
Noise
Degradation
Sun
Imaging techniques
Solar System
Artifacts
Costs
Costs and Cost Analysis

Keywords

  • Image reconstruction
  • Positron emission tomography (PET)
  • Small-animal pet scanner
  • Three-dimensional (3-D) reconstruction

ASJC Scopus subject areas

  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Electrical and Electronic Engineering
  • Computer Science Applications
  • Computational Theory and Mathematics

Cite this

An evaluation of exact and approximate 3-D reconstruction algorithms for a high- resolution, small-animal PET scanner. / Farquhar, T. H.; Chatziioannou, A.; Cherry, Simon R.

In: IEEE Transactions on Medical Imaging, Vol. 17, No. 6, 1998, p. 1073-1080.

Research output: Contribution to journalArticle

@article{dc52ac68a93a4fafaeec122df2ce0e25,
title = "An evaluation of exact and approximate 3-D reconstruction algorithms for a high- resolution, small-animal PET scanner",
abstract = "MicroPET is a low-cost, high-resolution positron emission tomography (PET) scanner designed for imaging small animals. MicroPET operates exclusively without septa, acquiring fully three-dimensional (3-D) data sets. The performance of the projection-reprojection (3DRP), variable axial rebinning (VARB), single slice rebinning (SSRB), and Fourier rebinning (FORE) methods for reconstruction of microPET data were evaluated. The algorithms were compared with respect to resolution, noise variance, and reconstruction time. Results suggested that the 3DRP algorithm gives the best combination of resolution and noise performance in 9 min of reconstruction time on a Sun UltraSparc I workstation. The FORE algorithm provided the most acceptable accelerated method of reconstruction, giving similar resolution performance with a 10{\%}-20{\%} degradation in noise variance in under 2 min. Significant degradation in the axial resolution was measured with the VARB and SSRB methods, offsetting the decrease in reconstruction time achieved with those methods. In-plane angular mashing of the 3-D data before reconstruction led to a 50{\%} reduction in reconstruction time but also introduced unacceptable tangential blurring artifacts. This thorough evaluation of analytical 3-D reconstruction techniques allowed for optimal selection of a reconstruction method for the diverse range of microPET applications.",
keywords = "Image reconstruction, Positron emission tomography (PET), Small-animal pet scanner, Three-dimensional (3-D) reconstruction",
author = "Farquhar, {T. H.} and A. Chatziioannou and Cherry, {Simon R}",
year = "1998",
language = "English (US)",
volume = "17",
pages = "1073--1080",
journal = "IEEE Transactions on Medical Imaging",
issn = "0278-0062",
publisher = "Institute of Electrical and Electronics Engineers Inc.",
number = "6",

}

TY - JOUR

T1 - An evaluation of exact and approximate 3-D reconstruction algorithms for a high- resolution, small-animal PET scanner

AU - Farquhar, T. H.

AU - Chatziioannou, A.

AU - Cherry, Simon R

PY - 1998

Y1 - 1998

N2 - MicroPET is a low-cost, high-resolution positron emission tomography (PET) scanner designed for imaging small animals. MicroPET operates exclusively without septa, acquiring fully three-dimensional (3-D) data sets. The performance of the projection-reprojection (3DRP), variable axial rebinning (VARB), single slice rebinning (SSRB), and Fourier rebinning (FORE) methods for reconstruction of microPET data were evaluated. The algorithms were compared with respect to resolution, noise variance, and reconstruction time. Results suggested that the 3DRP algorithm gives the best combination of resolution and noise performance in 9 min of reconstruction time on a Sun UltraSparc I workstation. The FORE algorithm provided the most acceptable accelerated method of reconstruction, giving similar resolution performance with a 10%-20% degradation in noise variance in under 2 min. Significant degradation in the axial resolution was measured with the VARB and SSRB methods, offsetting the decrease in reconstruction time achieved with those methods. In-plane angular mashing of the 3-D data before reconstruction led to a 50% reduction in reconstruction time but also introduced unacceptable tangential blurring artifacts. This thorough evaluation of analytical 3-D reconstruction techniques allowed for optimal selection of a reconstruction method for the diverse range of microPET applications.

AB - MicroPET is a low-cost, high-resolution positron emission tomography (PET) scanner designed for imaging small animals. MicroPET operates exclusively without septa, acquiring fully three-dimensional (3-D) data sets. The performance of the projection-reprojection (3DRP), variable axial rebinning (VARB), single slice rebinning (SSRB), and Fourier rebinning (FORE) methods for reconstruction of microPET data were evaluated. The algorithms were compared with respect to resolution, noise variance, and reconstruction time. Results suggested that the 3DRP algorithm gives the best combination of resolution and noise performance in 9 min of reconstruction time on a Sun UltraSparc I workstation. The FORE algorithm provided the most acceptable accelerated method of reconstruction, giving similar resolution performance with a 10%-20% degradation in noise variance in under 2 min. Significant degradation in the axial resolution was measured with the VARB and SSRB methods, offsetting the decrease in reconstruction time achieved with those methods. In-plane angular mashing of the 3-D data before reconstruction led to a 50% reduction in reconstruction time but also introduced unacceptable tangential blurring artifacts. This thorough evaluation of analytical 3-D reconstruction techniques allowed for optimal selection of a reconstruction method for the diverse range of microPET applications.

KW - Image reconstruction

KW - Positron emission tomography (PET)

KW - Small-animal pet scanner

KW - Three-dimensional (3-D) reconstruction

UR - http://www.scopus.com/inward/record.url?scp=0032216620&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032216620&partnerID=8YFLogxK

M3 - Article

C2 - 10048864

AN - SCOPUS:0032216620

VL - 17

SP - 1073

EP - 1080

JO - IEEE Transactions on Medical Imaging

JF - IEEE Transactions on Medical Imaging

SN - 0278-0062

IS - 6

ER -