Abstract
Galectin-3 is a member of a growing family of β-galactoside-binding animal lectins and previously designated as ε{lunate}BP (IgE-binding protein) by this laboratory and as Mac-2, CBP35, L-34 and L-29 by other researchers. While possible intracellular functions have been proposed for galectin-3, existing data also suggest an extracellular modulatory role of this lectin. For example, ε{lunate}BP/Mac-2 was found to be secreted by various cells and capable of activating mast cells, possibly through cross-linking of cell surface glycoproteins involved in cell activation. In this study, we showed that ε{lunate}BP bound to human monocytes via its lectin function. Furthermore, we found that ε{lunate}BP potentiated IL-1 production by monocytes in a manner that was inhibitable by the saccharide ligand of ε{lunate}BP. The results further support a role of this lectin in potentiating activities of inflammatory cells and thereby amplifying inflammatory responses.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 113-116 |
| Number of pages | 4 |
| Journal | Immunology Letters |
| Volume | 42 |
| Issue number | 3 |
| DOIs | |
| State | Published - 1994 |
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Keywords
- Animal lectin
- Galectin
- IgE
- Interleukin-1
- Macrophage
- Monocyte
ASJC Scopus subject areas
- Immunology
- Immunology and Allergy
Cite this
An endogenous lectin, galectin-3 (ε{lunate}BP / Mac-2), potentiates IL-1 production by human monocytes. / Jeng, Kee Ching G; Frigeri, Luciano G.; Liu, Fu-Tong.
In: Immunology Letters, Vol. 42, No. 3, 1994, p. 113-116.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - An endogenous lectin, galectin-3 (ε{lunate}BP / Mac-2), potentiates IL-1 production by human monocytes
AU - Jeng, Kee Ching G
AU - Frigeri, Luciano G.
AU - Liu, Fu-Tong
PY - 1994
Y1 - 1994
N2 - Galectin-3 is a member of a growing family of β-galactoside-binding animal lectins and previously designated as ε{lunate}BP (IgE-binding protein) by this laboratory and as Mac-2, CBP35, L-34 and L-29 by other researchers. While possible intracellular functions have been proposed for galectin-3, existing data also suggest an extracellular modulatory role of this lectin. For example, ε{lunate}BP/Mac-2 was found to be secreted by various cells and capable of activating mast cells, possibly through cross-linking of cell surface glycoproteins involved in cell activation. In this study, we showed that ε{lunate}BP bound to human monocytes via its lectin function. Furthermore, we found that ε{lunate}BP potentiated IL-1 production by monocytes in a manner that was inhibitable by the saccharide ligand of ε{lunate}BP. The results further support a role of this lectin in potentiating activities of inflammatory cells and thereby amplifying inflammatory responses.
AB - Galectin-3 is a member of a growing family of β-galactoside-binding animal lectins and previously designated as ε{lunate}BP (IgE-binding protein) by this laboratory and as Mac-2, CBP35, L-34 and L-29 by other researchers. While possible intracellular functions have been proposed for galectin-3, existing data also suggest an extracellular modulatory role of this lectin. For example, ε{lunate}BP/Mac-2 was found to be secreted by various cells and capable of activating mast cells, possibly through cross-linking of cell surface glycoproteins involved in cell activation. In this study, we showed that ε{lunate}BP bound to human monocytes via its lectin function. Furthermore, we found that ε{lunate}BP potentiated IL-1 production by monocytes in a manner that was inhibitable by the saccharide ligand of ε{lunate}BP. The results further support a role of this lectin in potentiating activities of inflammatory cells and thereby amplifying inflammatory responses.
KW - Animal lectin
KW - Galectin
KW - IgE
KW - Interleukin-1
KW - Macrophage
KW - Monocyte
UR - http://www.scopus.com/inward/record.url?scp=0028143189&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028143189&partnerID=8YFLogxK
U2 - 10.1016/0165-2478(94)90072-8
DO - 10.1016/0165-2478(94)90072-8
M3 - Article
VL - 42
SP - 113
EP - 116
JO - Immunology Letters
JF - Immunology Letters
SN - 0165-2478
IS - 3
ER -