An ellipsometry-based biosensor for label-free, real-time, and in-situ detection of DNA-DNA and DNA-protein interactions

Yung Shin Sun; Xiangdong Zhu

doi:10.6122/CJP.52.1398

An ellipsometry-based biosensor for label-free, real-time, and in-situ detection of DNA-DNA and DNA-protein interactions

Yung Shin Sun, Xiangdong Zhu

Physics, Applied Physics

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

An ellipsometry-based biosensor, the oblique-incidence reflectivity difference (OI-RD) scanning microscope, was developed for label-free, real-time, and in-situ detection of biomolecular interactions. We successfully demonstrate that DNA-DNA hybridization and DNA-protein reactions in a DNA microarray can be monitored by such an OI-RD microscope.

Original language	English (US)
Pages (from-to)	1398-1406
Number of pages	9
Journal	Chinese Journal of Physics
Volume	52
Issue number	4
DOIs	https://doi.org/10.6122/CJP.52.1398
State	Published - 2014

ASJC Scopus subject areas

Physics and Astronomy(all)

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abstract = "An ellipsometry-based biosensor, the oblique-incidence reflectivity difference (OI-RD) scanning microscope, was developed for label-free, real-time, and in-situ detection of biomolecular interactions. We successfully demonstrate that DNA-DNA hybridization and DNA-protein reactions in a DNA microarray can be monitored by such an OI-RD microscope.",

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AB - An ellipsometry-based biosensor, the oblique-incidence reflectivity difference (OI-RD) scanning microscope, was developed for label-free, real-time, and in-situ detection of biomolecular interactions. We successfully demonstrate that DNA-DNA hybridization and DNA-protein reactions in a DNA microarray can be monitored by such an OI-RD microscope.

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An ellipsometry-based biosensor for label-free, real-time, and in-situ detection of DNA-DNA and DNA-protein interactions

Abstract

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