An ellipsometry-based biosensor for label-free, real-time, and in-situ detection of DNA-DNA and DNA-protein interactions

Yung Shin Sun, Xiangdong Zhu

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

An ellipsometry-based biosensor, the oblique-incidence reflectivity difference (OI-RD) scanning microscope, was developed for label-free, real-time, and in-situ detection of biomolecular interactions. We successfully demonstrate that DNA-DNA hybridization and DNA-protein reactions in a DNA microarray can be monitored by such an OI-RD microscope.

Original languageEnglish (US)
Pages (from-to)1398-1406
Number of pages9
JournalChinese Journal of Physics
Volume52
Issue number4
DOIs
StatePublished - 2014

ASJC Scopus subject areas

  • Physics and Astronomy(all)

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