An elevated bronchodilator response predicts large airway inflammation in mild asthma

James L. Puckett, Richard W.E. Taylor, Szu Yun Leu, Olga L. Guijon, Anna S. Aledia, Stanley P. Galant, Steven George

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Exhaled nitric oxide (eNO) is elevated in asthmatics and is a purported marker of airway inflammation. The bronchodilator response (BDR) has also been shown to correlate with markers of airway inflammation, including eNO at 50 ml/sec (FENO,50) which is comprised of NO from both the proximal and distal airways. Using eNO at multiple flows and a two-compartment model of NO exchange, the eNO signal can be partitioned into its proximal [J'awNO (nl/sec)] and distal contributions [CANO (ppb)].We hypothesized that theBDRreflects the inflammatory status of the larger airways with smooth muscle, and thuswould correlate with J'awNO. In 179 predominantly (95%) Hispanic children with mild asthma (69 steroid naïve), and 21 non-asthmatic non-atopic controls, spirometry andeNOat multiple flowswere measured prior and 10 min following inhalation of albuterol. A trumpet-shaped axial diffusion model of NO exchange was used to characterize J'awNO and CANO. The BDR correlated moderately (r=0.44) with proximal airway NO (J'awNO), but weakly (r=0.26) with distal airway/alveolar NO (CANO), and only in inhaled corticosteroid naïve asthmatics. A BDR cut point as low as ≥8% had a positive predictive value of 83% for predicting an elevated J'aw NO or FENO,50. We conclude that the BDR reflects inflammation in the large airways, and may be an effective clinical tool to predict elevated large airway inflammation.

Original languageEnglish (US)
Pages (from-to)174-181
Number of pages8
JournalPediatric Pulmonology
Volume45
Issue number2
DOIs
StatePublished - Feb 1 2010

Fingerprint

Bronchodilator Agents
Nitric Oxide
Asthma
Inflammation
Albuterol
Spirometry
Hispanic Americans
Inhalation
Smooth Muscle
Adrenal Cortex Hormones
Steroids

Keywords

  • Inflammation
  • Nitric oxide
  • NO
  • Pulmonary function

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pulmonary and Respiratory Medicine

Cite this

Puckett, J. L., Taylor, R. W. E., Leu, S. Y., Guijon, O. L., Aledia, A. S., Galant, S. P., & George, S. (2010). An elevated bronchodilator response predicts large airway inflammation in mild asthma. Pediatric Pulmonology, 45(2), 174-181. https://doi.org/10.1002/ppul.21172

An elevated bronchodilator response predicts large airway inflammation in mild asthma. / Puckett, James L.; Taylor, Richard W.E.; Leu, Szu Yun; Guijon, Olga L.; Aledia, Anna S.; Galant, Stanley P.; George, Steven.

In: Pediatric Pulmonology, Vol. 45, No. 2, 01.02.2010, p. 174-181.

Research output: Contribution to journalArticle

Puckett, JL, Taylor, RWE, Leu, SY, Guijon, OL, Aledia, AS, Galant, SP & George, S 2010, 'An elevated bronchodilator response predicts large airway inflammation in mild asthma', Pediatric Pulmonology, vol. 45, no. 2, pp. 174-181. https://doi.org/10.1002/ppul.21172
Puckett JL, Taylor RWE, Leu SY, Guijon OL, Aledia AS, Galant SP et al. An elevated bronchodilator response predicts large airway inflammation in mild asthma. Pediatric Pulmonology. 2010 Feb 1;45(2):174-181. https://doi.org/10.1002/ppul.21172
Puckett, James L. ; Taylor, Richard W.E. ; Leu, Szu Yun ; Guijon, Olga L. ; Aledia, Anna S. ; Galant, Stanley P. ; George, Steven. / An elevated bronchodilator response predicts large airway inflammation in mild asthma. In: Pediatric Pulmonology. 2010 ; Vol. 45, No. 2. pp. 174-181.
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