An efficient F-18 labeling method for PET study: Huisgen 1,3-dipolar cycloaddition of bioactive substances and F-18-labeled compounds

Uthaiwan Sirion, Hee Jun Kim, Jae Hak Lee, Jai Seo, Byoung Se Lee, Sang Ju Lee, Seung Jun Oh, Dae Yoon Chi

Research output: Contribution to journalArticle

70 Scopus citations

Abstract

The Cu(I)-catalyzed, 1,3-dipolar cycloaddition reaction was applied successfully to the synthesis of small, F-18-labeled biomolecules, and an optimal condition was developed for one-pot, two-step reaction without any interim purifications. This technique was employed in various F-18-labeled, 1,2,3-triazole syntheses with high radiochemical yield.

Original languageEnglish (US)
Pages (from-to)3953-3957
Number of pages5
JournalTetrahedron Letters
Volume48
Issue number23
DOIs
StatePublished - Jun 4 2007
Externally publishedYes

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ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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