An efficient F-18 labeling method for PET study

Huisgen 1,3-dipolar cycloaddition of bioactive substances and F-18-labeled compounds

Uthaiwan Sirion, Hee Jun Kim, Jae Hak Lee, Jai Seo, Byoung Se Lee, Sang Ju Lee, Seung Jun Oh, Dae Yoon Chi

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

The Cu(I)-catalyzed, 1,3-dipolar cycloaddition reaction was applied successfully to the synthesis of small, F-18-labeled biomolecules, and an optimal condition was developed for one-pot, two-step reaction without any interim purifications. This technique was employed in various F-18-labeled, 1,2,3-triazole syntheses with high radiochemical yield.

Original languageEnglish (US)
Pages (from-to)3953-3957
Number of pages5
JournalTetrahedron Letters
Volume48
Issue number23
DOIs
StatePublished - Jun 4 2007
Externally publishedYes

Fingerprint

Triazoles
Cycloaddition
Cycloaddition Reaction
Labeling
Biomolecules
Purification
poriferasterol monoglucoside
compound 18

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Cite this

An efficient F-18 labeling method for PET study : Huisgen 1,3-dipolar cycloaddition of bioactive substances and F-18-labeled compounds. / Sirion, Uthaiwan; Kim, Hee Jun; Lee, Jae Hak; Seo, Jai; Lee, Byoung Se; Lee, Sang Ju; Oh, Seung Jun; Chi, Dae Yoon.

In: Tetrahedron Letters, Vol. 48, No. 23, 04.06.2007, p. 3953-3957.

Research output: Contribution to journalArticle

Sirion, Uthaiwan ; Kim, Hee Jun ; Lee, Jae Hak ; Seo, Jai ; Lee, Byoung Se ; Lee, Sang Ju ; Oh, Seung Jun ; Chi, Dae Yoon. / An efficient F-18 labeling method for PET study : Huisgen 1,3-dipolar cycloaddition of bioactive substances and F-18-labeled compounds. In: Tetrahedron Letters. 2007 ; Vol. 48, No. 23. pp. 3953-3957.
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