An efficient approach to prepare glyoxylyl functionality on solid-support

Qingchai Xu, Kit Lam

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Glyoxylyl group on solid-support is an attractive intermediate for solid-phase synthesis, and combinatorial synthesis. We report here a novel method to generate glyoxylyl functionality on solid-support that involves coupling of acrylic acid, followed by oxidation of the double bond. This highly efficient and versatile approach is compatible with hydroxyl-resins, amino-resins and other solid supports such as glass surfaces.

Original languageEnglish (US)
Pages (from-to)4435-4437
Number of pages3
JournalTetrahedron Letters
Volume43
Issue number25
DOIs
StatePublished - Jun 17 2002

Fingerprint

Solid-Phase Synthesis Techniques
Hydroxyl Radical
Glass
Oxidation
acrylic acid

Keywords

  • Aldehydes
  • Chemoselective ligation
  • Glass slide
  • Glyoxylyl functionality
  • Solid-phase

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

An efficient approach to prepare glyoxylyl functionality on solid-support. / Xu, Qingchai; Lam, Kit.

In: Tetrahedron Letters, Vol. 43, No. 25, 17.06.2002, p. 4435-4437.

Research output: Contribution to journalArticle

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