An attempt to reproduce 'mal seco' in horses by feeding them Festuca argentina

Francisco A Uzal, M. P. Woodman, C. G. Giraudo, C. A. Robles, D. L. Doxey

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

'Mal seco' is an almost invariably fatal disease of horses in Argentina and Chile, which resembles grass sickness, a dysautonomia of horses in Europe. The aetiology of mal seco remains unknown. An attempt to reproduce the disease was made by feeding horses with Festuca argentina, a plant considered to be toxic to animals and which was consistently found in the diet of nine horses suffering from mal seco. Three horses were fed with F argentina ad libitum for 28 days. The plant was infected with an endophytic fungus, whose morphological characteristics were in agreement with descriptions of Acremonium chlamydosporioides. No clinical abnormalities were observed in two of the horses, but one died on the fifth day of the trial after becoming incoordinated, unsteady and ataxic in the fore- and hindlimbs. No gross changes were observed post mortem in any of the horses, with the exception of a small number of Fasciola hepatica in the liver of the horse which died, and a moderate number of Gasterophilus species in the stomach of all three horses. No histopathological changes were observed in any of the organs examined, including several autonomic ganglia, brain including most brain stem nuclei, spinal cord, liver, kidney, stomach and small and large intestine. The results of this study suggest that F argentina is either not implicated in the aetiology of mal seco or produces its effects only when they are triggered by other unknown factors.

Original languageEnglish (US)
Pages (from-to)68-70
Number of pages3
JournalVeterinary Record
Volume139
Issue number3
StatePublished - Jul 20 1996
Externally publishedYes

Fingerprint

Festuca
Horses
horses
Argentina
etiology
Stomach
stomach
Gasterophilus
dysautonomia
Autonomic Ganglia
Primary Dysautonomias
grass sickness
Horse Diseases
Acremonium
Fasciola hepatica
horse diseases
liver
Forelimb
Festuca argentina
Chile

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Uzal, F. A., Woodman, M. P., Giraudo, C. G., Robles, C. A., & Doxey, D. L. (1996). An attempt to reproduce 'mal seco' in horses by feeding them Festuca argentina. Veterinary Record, 139(3), 68-70.

An attempt to reproduce 'mal seco' in horses by feeding them Festuca argentina. / Uzal, Francisco A; Woodman, M. P.; Giraudo, C. G.; Robles, C. A.; Doxey, D. L.

In: Veterinary Record, Vol. 139, No. 3, 20.07.1996, p. 68-70.

Research output: Contribution to journalArticle

Uzal, FA, Woodman, MP, Giraudo, CG, Robles, CA & Doxey, DL 1996, 'An attempt to reproduce 'mal seco' in horses by feeding them Festuca argentina', Veterinary Record, vol. 139, no. 3, pp. 68-70.
Uzal FA, Woodman MP, Giraudo CG, Robles CA, Doxey DL. An attempt to reproduce 'mal seco' in horses by feeding them Festuca argentina. Veterinary Record. 1996 Jul 20;139(3):68-70.
Uzal, Francisco A ; Woodman, M. P. ; Giraudo, C. G. ; Robles, C. A. ; Doxey, D. L. / An attempt to reproduce 'mal seco' in horses by feeding them Festuca argentina. In: Veterinary Record. 1996 ; Vol. 139, No. 3. pp. 68-70.
@article{30e441aa1fa945bea3f797cedea2033e,
title = "An attempt to reproduce 'mal seco' in horses by feeding them Festuca argentina",
abstract = "'Mal seco' is an almost invariably fatal disease of horses in Argentina and Chile, which resembles grass sickness, a dysautonomia of horses in Europe. The aetiology of mal seco remains unknown. An attempt to reproduce the disease was made by feeding horses with Festuca argentina, a plant considered to be toxic to animals and which was consistently found in the diet of nine horses suffering from mal seco. Three horses were fed with F argentina ad libitum for 28 days. The plant was infected with an endophytic fungus, whose morphological characteristics were in agreement with descriptions of Acremonium chlamydosporioides. No clinical abnormalities were observed in two of the horses, but one died on the fifth day of the trial after becoming incoordinated, unsteady and ataxic in the fore- and hindlimbs. No gross changes were observed post mortem in any of the horses, with the exception of a small number of Fasciola hepatica in the liver of the horse which died, and a moderate number of Gasterophilus species in the stomach of all three horses. No histopathological changes were observed in any of the organs examined, including several autonomic ganglia, brain including most brain stem nuclei, spinal cord, liver, kidney, stomach and small and large intestine. The results of this study suggest that F argentina is either not implicated in the aetiology of mal seco or produces its effects only when they are triggered by other unknown factors.",
author = "Uzal, {Francisco A} and Woodman, {M. P.} and Giraudo, {C. G.} and Robles, {C. A.} and Doxey, {D. L.}",
year = "1996",
month = "7",
day = "20",
language = "English (US)",
volume = "139",
pages = "68--70",
journal = "Veterinary Record",
issn = "0042-4900",
publisher = "British Veterinary Association",
number = "3",

}

TY - JOUR

T1 - An attempt to reproduce 'mal seco' in horses by feeding them Festuca argentina

AU - Uzal, Francisco A

AU - Woodman, M. P.

AU - Giraudo, C. G.

AU - Robles, C. A.

AU - Doxey, D. L.

PY - 1996/7/20

Y1 - 1996/7/20

N2 - 'Mal seco' is an almost invariably fatal disease of horses in Argentina and Chile, which resembles grass sickness, a dysautonomia of horses in Europe. The aetiology of mal seco remains unknown. An attempt to reproduce the disease was made by feeding horses with Festuca argentina, a plant considered to be toxic to animals and which was consistently found in the diet of nine horses suffering from mal seco. Three horses were fed with F argentina ad libitum for 28 days. The plant was infected with an endophytic fungus, whose morphological characteristics were in agreement with descriptions of Acremonium chlamydosporioides. No clinical abnormalities were observed in two of the horses, but one died on the fifth day of the trial after becoming incoordinated, unsteady and ataxic in the fore- and hindlimbs. No gross changes were observed post mortem in any of the horses, with the exception of a small number of Fasciola hepatica in the liver of the horse which died, and a moderate number of Gasterophilus species in the stomach of all three horses. No histopathological changes were observed in any of the organs examined, including several autonomic ganglia, brain including most brain stem nuclei, spinal cord, liver, kidney, stomach and small and large intestine. The results of this study suggest that F argentina is either not implicated in the aetiology of mal seco or produces its effects only when they are triggered by other unknown factors.

AB - 'Mal seco' is an almost invariably fatal disease of horses in Argentina and Chile, which resembles grass sickness, a dysautonomia of horses in Europe. The aetiology of mal seco remains unknown. An attempt to reproduce the disease was made by feeding horses with Festuca argentina, a plant considered to be toxic to animals and which was consistently found in the diet of nine horses suffering from mal seco. Three horses were fed with F argentina ad libitum for 28 days. The plant was infected with an endophytic fungus, whose morphological characteristics were in agreement with descriptions of Acremonium chlamydosporioides. No clinical abnormalities were observed in two of the horses, but one died on the fifth day of the trial after becoming incoordinated, unsteady and ataxic in the fore- and hindlimbs. No gross changes were observed post mortem in any of the horses, with the exception of a small number of Fasciola hepatica in the liver of the horse which died, and a moderate number of Gasterophilus species in the stomach of all three horses. No histopathological changes were observed in any of the organs examined, including several autonomic ganglia, brain including most brain stem nuclei, spinal cord, liver, kidney, stomach and small and large intestine. The results of this study suggest that F argentina is either not implicated in the aetiology of mal seco or produces its effects only when they are triggered by other unknown factors.

UR - http://www.scopus.com/inward/record.url?scp=0030594655&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030594655&partnerID=8YFLogxK

M3 - Article

C2 - 8857579

AN - SCOPUS:0030594655

VL - 139

SP - 68

EP - 70

JO - Veterinary Record

JF - Veterinary Record

SN - 0042-4900

IS - 3

ER -