An association study of bipolar mood disorder (type I) with the 5-HTTLPR serotonin transporter polymorphism in a human population isolate from Colombia

Jorge Ospina-Duque, Constanza Duque, Luis Carvajal-Carmona, Daniel Ortiz-Barrientos, Ivan Soto, Nicolas Pineda, Mauricio Cuartas, Jorge Calle, Carlos Lopez, Luis Ochoa, Jenny Garcia, Juliana Gomez, Angela Agudelo, Maria Lozano, Gabriel Montoya, Angelica Ospina, Maria Lopez, Aurora Gallo, Ana Miranda, Lina SernaPatricia Montoya, Carlos Palacio, Gabriel Bedoya, Mark McCarthy, Victor Reus, Nelson Freimer, Andres Ruiz-Linares

Research output: Contribution to journalArticlepeer-review

73 Scopus citations

Abstract

The short variant of a functional length polymorphism in the promoter region of the serotonin transporter has been associated with several behavioural and psychiatric traits, including bipolar mood disorder. The same short allele has also been implicated as a modifier of the bipolar phenotype. Here we evaluate the etiologic/modifier role of this polymorphism in a case (N = 103) / control (N = 112) sample for bipolar mood disorder (type I) collected from an isolated South American population. We did not detect an association between bipolar disorder and the 5-HTT promoter polymorphism in this sample. However, an excess of the short allele was seen in younger cases and in cases with psychotic symptoms. When combined with data from the literature, the increased frequency of the short allele in patients with psychotic symptoms was statistically significant. (C) 2000 Elsevier Science Ireland Ltd.

Original languageEnglish (US)
Pages (from-to)199-202
Number of pages4
JournalNeuroscience Letters
Volume292
Issue number3
DOIs
StatePublished - Oct 13 2000
Externally publishedYes

Keywords

  • Bipolar mood disorder
  • Population isolates
  • Serotonin transporter

ASJC Scopus subject areas

  • Neuroscience(all)

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