Abstract
The short variant of a functional length polymorphism in the promoter region of the serotonin transporter has been associated with several behavioural and psychiatric traits, including bipolar mood disorder. The same short allele has also been implicated as a modifier of the bipolar phenotype. Here we evaluate the etiologic/modifier role of this polymorphism in a case (N = 103) / control (N = 112) sample for bipolar mood disorder (type I) collected from an isolated South American population. We did not detect an association between bipolar disorder and the 5-HTT promoter polymorphism in this sample. However, an excess of the short allele was seen in younger cases and in cases with psychotic symptoms. When combined with data from the literature, the increased frequency of the short allele in patients with psychotic symptoms was statistically significant. (C) 2000 Elsevier Science Ireland Ltd.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 199-202 |
| Number of pages | 4 |
| Journal | Neuroscience Letters |
| Volume | 292 |
| Issue number | 3 |
| DOIs | |
| State | Published - Oct 13 2000 |
| Externally published | Yes |
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Keywords
- Bipolar mood disorder
- Population isolates
- Serotonin transporter
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
An association study of bipolar mood disorder (type I) with the 5-HTTLPR serotonin transporter polymorphism in a human population isolate from Colombia. / Ospina-Duque, Jorge; Duque, Constanza; Carvajal-Carmona, Luis; Ortiz-Barrientos, Daniel; Soto, Ivan; Pineda, Nicolas; Cuartas, Mauricio; Calle, Jorge; Lopez, Carlos; Ochoa, Luis; Garcia, Jenny; Gomez, Juliana; Agudelo, Angela; Lozano, Maria; Montoya, Gabriel; Ospina, Angelica; Lopez, Maria; Gallo, Aurora; Miranda, Ana; Serna, Lina; Montoya, Patricia; Palacio, Carlos; Bedoya, Gabriel; McCarthy, Mark; Reus, Victor; Freimer, Nelson; Ruiz-Linares, Andres.
In: Neuroscience Letters, Vol. 292, No. 3, 13.10.2000, p. 199-202.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - An association study of bipolar mood disorder (type I) with the 5-HTTLPR serotonin transporter polymorphism in a human population isolate from Colombia
AU - Ospina-Duque, Jorge
AU - Duque, Constanza
AU - Carvajal-Carmona, Luis
AU - Ortiz-Barrientos, Daniel
AU - Soto, Ivan
AU - Pineda, Nicolas
AU - Cuartas, Mauricio
AU - Calle, Jorge
AU - Lopez, Carlos
AU - Ochoa, Luis
AU - Garcia, Jenny
AU - Gomez, Juliana
AU - Agudelo, Angela
AU - Lozano, Maria
AU - Montoya, Gabriel
AU - Ospina, Angelica
AU - Lopez, Maria
AU - Gallo, Aurora
AU - Miranda, Ana
AU - Serna, Lina
AU - Montoya, Patricia
AU - Palacio, Carlos
AU - Bedoya, Gabriel
AU - McCarthy, Mark
AU - Reus, Victor
AU - Freimer, Nelson
AU - Ruiz-Linares, Andres
PY - 2000/10/13
Y1 - 2000/10/13
N2 - The short variant of a functional length polymorphism in the promoter region of the serotonin transporter has been associated with several behavioural and psychiatric traits, including bipolar mood disorder. The same short allele has also been implicated as a modifier of the bipolar phenotype. Here we evaluate the etiologic/modifier role of this polymorphism in a case (N = 103) / control (N = 112) sample for bipolar mood disorder (type I) collected from an isolated South American population. We did not detect an association between bipolar disorder and the 5-HTT promoter polymorphism in this sample. However, an excess of the short allele was seen in younger cases and in cases with psychotic symptoms. When combined with data from the literature, the increased frequency of the short allele in patients with psychotic symptoms was statistically significant. (C) 2000 Elsevier Science Ireland Ltd.
AB - The short variant of a functional length polymorphism in the promoter region of the serotonin transporter has been associated with several behavioural and psychiatric traits, including bipolar mood disorder. The same short allele has also been implicated as a modifier of the bipolar phenotype. Here we evaluate the etiologic/modifier role of this polymorphism in a case (N = 103) / control (N = 112) sample for bipolar mood disorder (type I) collected from an isolated South American population. We did not detect an association between bipolar disorder and the 5-HTT promoter polymorphism in this sample. However, an excess of the short allele was seen in younger cases and in cases with psychotic symptoms. When combined with data from the literature, the increased frequency of the short allele in patients with psychotic symptoms was statistically significant. (C) 2000 Elsevier Science Ireland Ltd.
KW - Bipolar mood disorder
KW - Population isolates
KW - Serotonin transporter
UR - http://www.scopus.com/inward/record.url?scp=0034644955&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034644955&partnerID=8YFLogxK
U2 - 10.1016/S0304-3940(00)01464-6
DO - 10.1016/S0304-3940(00)01464-6
M3 - Article
VL - 292
SP - 199
EP - 202
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
IS - 3
ER -