An artificial neural network improves prediction of observed survival in patients with laryngeal squamous carcinoma

Andrew S. Jones, Azzam G F Taktak, Timothy R. Helliwell, John E. Fenton, Martin A. Birchall, David J. Husband, Anthony C. Fisher

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

The accepted method of modelling and predicting failure/survival, Cox's proportional hazards model, is theoretically inferior to neural network derived models for analysing highly complex systems with large datasets. A blinded comparison of the neural network versus the Cox's model in predicting survival utilising data from 873 treated patients with laryngeal cancer. These were divided randomly and equally into a training set and a study set and Cox's and neural network models applied in turn. Data were then divided into seven sets of binary covariates and the analysis repeated. Overall survival was not significantly different on Kaplan-Meier plot, or with either test model. Although the network produced qualitatively similar results to Cox's model it was significantly more sensitive to differences in survival curves for age and N stage. We propose that neural networks are capable of prediction in systems involving complex interactions between variables and non-linearity.

Original languageEnglish (US)
Pages (from-to)541-547
Number of pages7
JournalEuropean Archives of Oto-Rhino-Laryngology
Volume263
Issue number6
DOIs
StatePublished - Jun 2006
Externally publishedYes

Keywords

  • Artificial intelligence
  • Chaos
  • Complex systems modeling
  • Laryngeal carcinoma

ASJC Scopus subject areas

  • Otorhinolaryngology

Fingerprint Dive into the research topics of 'An artificial neural network improves prediction of observed survival in patients with laryngeal squamous carcinoma'. Together they form a unique fingerprint.

  • Cite this

    Jones, A. S., Taktak, A. G. F., Helliwell, T. R., Fenton, J. E., Birchall, M. A., Husband, D. J., & Fisher, A. C. (2006). An artificial neural network improves prediction of observed survival in patients with laryngeal squamous carcinoma. European Archives of Oto-Rhino-Laryngology, 263(6), 541-547. https://doi.org/10.1007/s00405-006-0021-2