An approach for evaluating the effects of dietary fiber polysaccharides on the human gut microbiome and plasma proteome

Omar Delannoy-Bruno, Chandani Desai, Juan J. Castillo, Garret Couture, Ruteja A. Barve, Vincent Lombard, Bernard Henrissat, Jiye Cheng, Nathan Han, David K. Hayashi, Alexandra Meynier, Sophie Vinoy, Carlito B. Lebrilla, Stacey Marion, Andrew C. Heath, Michael J. Barratt, Jeffrey I. Gordon

Research output: Contribution to journalArticlepeer-review

Abstract

SignificanceDietary fibers contain complex mixtures of biomolecules, making it difficult to develop/test hypotheses about how different fiber-types impact different components of the human gut microbiome and how microbiome changes that they produce are linked to human physiology. Here, we analyze microbiome and plasma proteome responses to consumption of two fiber-enriched snacks in two human studies. We use a variety of computational methods to correlate their effects on gut microbiome genes encoding enzymes that degrade complex fiber-associated polysaccharides, the microbial products of polysaccharide degradation, and plasma proteins representing diverse physiological processes. This approach can be used to guide the design of fiber-containing snacks that more precisely manipulate microbiome features in ways that improve nutritional and health status.

Original languageEnglish (US)
Pages (from-to)e2123411119
JournalProceedings of the National Academy of Sciences of the United States of America
Volume119
Issue number20
DOIs
StatePublished - May 17 2022

Keywords

  • carbohydrate-active enzymes
  • fiber-glycan metabolism
  • gut microbiome-directed foods
  • microbiome-plasma proteome relationships

ASJC Scopus subject areas

  • General

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