TY - JOUR
T1 - An approach for evaluating the effects of dietary fiber polysaccharides on the human gut microbiome and plasma proteome
AU - Delannoy-Bruno, Omar
AU - Desai, Chandani
AU - Castillo, Juan J.
AU - Couture, Garret
AU - Barve, Ruteja A.
AU - Lombard, Vincent
AU - Henrissat, Bernard
AU - Cheng, Jiye
AU - Han, Nathan
AU - Hayashi, David K.
AU - Meynier, Alexandra
AU - Vinoy, Sophie
AU - Lebrilla, Carlito B.
AU - Marion, Stacey
AU - Heath, Andrew C.
AU - Barratt, Michael J.
AU - Gordon, Jeffrey I.
PY - 2022/5/17
Y1 - 2022/5/17
N2 - SignificanceDietary fibers contain complex mixtures of biomolecules, making it difficult to develop/test hypotheses about how different fiber-types impact different components of the human gut microbiome and how microbiome changes that they produce are linked to human physiology. Here, we analyze microbiome and plasma proteome responses to consumption of two fiber-enriched snacks in two human studies. We use a variety of computational methods to correlate their effects on gut microbiome genes encoding enzymes that degrade complex fiber-associated polysaccharides, the microbial products of polysaccharide degradation, and plasma proteins representing diverse physiological processes. This approach can be used to guide the design of fiber-containing snacks that more precisely manipulate microbiome features in ways that improve nutritional and health status.
AB - SignificanceDietary fibers contain complex mixtures of biomolecules, making it difficult to develop/test hypotheses about how different fiber-types impact different components of the human gut microbiome and how microbiome changes that they produce are linked to human physiology. Here, we analyze microbiome and plasma proteome responses to consumption of two fiber-enriched snacks in two human studies. We use a variety of computational methods to correlate their effects on gut microbiome genes encoding enzymes that degrade complex fiber-associated polysaccharides, the microbial products of polysaccharide degradation, and plasma proteins representing diverse physiological processes. This approach can be used to guide the design of fiber-containing snacks that more precisely manipulate microbiome features in ways that improve nutritional and health status.
KW - carbohydrate-active enzymes
KW - fiber-glycan metabolism
KW - gut microbiome-directed foods
KW - microbiome-plasma proteome relationships
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U2 - 10.1073/pnas.2123411119
DO - 10.1073/pnas.2123411119
M3 - Article
C2 - 35533274
AN - SCOPUS:85129512137
VL - 119
SP - e2123411119
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
SN - 0027-8424
IS - 20
ER -