Rats treated with the anxiogenic β-carboline, N-methyl-β-carboline-3-carboxamide (FG-7142), failed to acquire an excape response 24 h after treatment. Administration of FG-7142 resulted in a behavioral effect equivalent to a session of inescapable tailshock in this paradigm of learned helplessness. Pretreatment of rats with the selective benzodiazepine receptor antagonist Ro15-1788 blocked the development of learned helplessness elicited by FG-7142. These findings suggest that 'anxiety' may be a major factor in the development of learned helplessness.
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience