An anxiogenic benzodiazepine receptor ligand induces learned helplessness

Robert C. Drugan, Steven F. Maier, Phil Skolnick, Steven M. Paul, Jacqueline Crawley

Research output: Contribution to journalArticle

92 Citations (Scopus)

Abstract

Rats treated with the anxiogenic β-carboline, N-methyl-β-carboline-3-carboxamide (FG-7142), failed to acquire an excape response 24 h after treatment. Administration of FG-7142 resulted in a behavioral effect equivalent to a session of inescapable tailshock in this paradigm of learned helplessness. Pretreatment of rats with the selective benzodiazepine receptor antagonist Ro15-1788 blocked the development of learned helplessness elicited by FG-7142. These findings suggest that 'anxiety' may be a major factor in the development of learned helplessness.

Original languageEnglish (US)
Pages (from-to)453-457
Number of pages5
JournalEuropean Journal of Pharmacology
Volume113
Issue number3
DOIs
StatePublished - Jul 31 1985
Externally publishedYes

Fingerprint

Learned Helplessness
GABA-A Receptors
Carbolines
Ligands
Anxiety
FG 7142

Keywords

  • Antagonist
  • Anxiety
  • Depression
  • β-Carboline

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

An anxiogenic benzodiazepine receptor ligand induces learned helplessness. / Drugan, Robert C.; Maier, Steven F.; Skolnick, Phil; Paul, Steven M.; Crawley, Jacqueline.

In: European Journal of Pharmacology, Vol. 113, No. 3, 31.07.1985, p. 453-457.

Research output: Contribution to journalArticle

Drugan, Robert C. ; Maier, Steven F. ; Skolnick, Phil ; Paul, Steven M. ; Crawley, Jacqueline. / An anxiogenic benzodiazepine receptor ligand induces learned helplessness. In: European Journal of Pharmacology. 1985 ; Vol. 113, No. 3. pp. 453-457.
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