An analysis of lethal and sublethal interactions among type I and type II pyrethroid pesticide mixtures using standard Hyalella azteca water column toxicity tests

Krista Callinan Hoffmann, Linda Deanovic, Inge Werner, Marie Stillway, Stephanie Fong, Swee J Teh

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A novel 2-tiered analytical approach was used to characterize and quantify interactions between type I and type II pyrethroids in Hyalella azteca using standardized water column toxicity tests. Bifenthrin, permethrin, cyfluthrin, and lambda-cyhalothrin were tested in all possible binary combinations across 6 experiments. All mixtures were analyzed for 4-d lethality, and 2 of the 6 mixtures (permethrin–bifenthrin and permethrin–cyfluthrin) were tested for subchronic 10-d lethality and sublethal effects on swimming motility and growth. Mixtures were initially analyzed for interactions using regression analyses, and subsequently compared with the additive models of concentration addition and independent action to further characterize mixture responses. Negative interactions (antagonistic) were significant in 2 of the 6 mixtures tested, including cyfluthrin–bifenthrin and cyfluthrin–permethrin, but only on the acute 4-d lethality endpoint. In both cases mixture responses fell between the additive models of concentration addition and independent action. All other mixtures were additive across 4-d lethality, and bifenthrin–permethrin and cyfluthrin–permethrin were also additive in terms of subchronic 10-d lethality and sublethal responses. Environ Toxicol Chem 2016;35:2542–2549.

Original languageEnglish (US)
Pages (from-to)2542-2549
Number of pages8
JournalEnvironmental Toxicology and Chemistry
Volume35
Issue number10
DOIs
StatePublished - Oct 1 2016

Fingerprint

Permethrin
Toxicity Tests
Pyrethrins
toxicity test
Pesticides
Toxicity
water column
Regression Analysis
bifenthrin
permethrin
pyrethroid
Water
sublethal effect
motility
Growth
experiment
Environ
cyfluthrin
cyhalothrin
pyrethroid pesticide

Keywords

  • Concentration addition
  • Dose–response modeling
  • Independent action
  • Mixture toxicology
  • Mixtures
  • Pyrethroids
  • Risk assessment
  • Sublethal effects

ASJC Scopus subject areas

  • Environmental Chemistry
  • Health, Toxicology and Mutagenesis

Cite this

An analysis of lethal and sublethal interactions among type I and type II pyrethroid pesticide mixtures using standard Hyalella azteca water column toxicity tests. / Hoffmann, Krista Callinan; Deanovic, Linda; Werner, Inge; Stillway, Marie; Fong, Stephanie; Teh, Swee J.

In: Environmental Toxicology and Chemistry, Vol. 35, No. 10, 01.10.2016, p. 2542-2549.

Research output: Contribution to journalArticle

Hoffmann, Krista Callinan ; Deanovic, Linda ; Werner, Inge ; Stillway, Marie ; Fong, Stephanie ; Teh, Swee J. / An analysis of lethal and sublethal interactions among type I and type II pyrethroid pesticide mixtures using standard Hyalella azteca water column toxicity tests. In: Environmental Toxicology and Chemistry. 2016 ; Vol. 35, No. 10. pp. 2542-2549.
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