An African American family with early-onset Alzheimer disease and an APP (T714I) mutation

T. Edwards-Lee, J. M. Ringman, J. Chung, John S Werner, A. Morgan, P. St. George Hyslop, P. Thompson, R. Dutton, A. Mlikotic, E. Rogaeva, J. Hardy

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

The occurrence of an APP T174I mutation is described in a large American family of African descent with Alzheimer disease. The clinical characteristics were an unusually early onset of disease (early 30s), similar to a previously reported age at onset of this mutation in an Austrian family. Distinct from that family, seizures and myoclonus were prominent features of the disease in this kindred.

Original languageEnglish (US)
Pages (from-to)377-379
Number of pages3
JournalNeurology
Volume64
Issue number2
StatePublished - Jan 25 2005
Externally publishedYes

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African Americans
Alzheimer Disease
Mutation
Myoclonus
Age of Onset
Seizures

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Edwards-Lee, T., Ringman, J. M., Chung, J., Werner, J. S., Morgan, A., St. George Hyslop, P., ... Hardy, J. (2005). An African American family with early-onset Alzheimer disease and an APP (T714I) mutation. Neurology, 64(2), 377-379.

An African American family with early-onset Alzheimer disease and an APP (T714I) mutation. / Edwards-Lee, T.; Ringman, J. M.; Chung, J.; Werner, John S; Morgan, A.; St. George Hyslop, P.; Thompson, P.; Dutton, R.; Mlikotic, A.; Rogaeva, E.; Hardy, J.

In: Neurology, Vol. 64, No. 2, 25.01.2005, p. 377-379.

Research output: Contribution to journalArticle

Edwards-Lee, T, Ringman, JM, Chung, J, Werner, JS, Morgan, A, St. George Hyslop, P, Thompson, P, Dutton, R, Mlikotic, A, Rogaeva, E & Hardy, J 2005, 'An African American family with early-onset Alzheimer disease and an APP (T714I) mutation', Neurology, vol. 64, no. 2, pp. 377-379.
Edwards-Lee T, Ringman JM, Chung J, Werner JS, Morgan A, St. George Hyslop P et al. An African American family with early-onset Alzheimer disease and an APP (T714I) mutation. Neurology. 2005 Jan 25;64(2):377-379.
Edwards-Lee, T. ; Ringman, J. M. ; Chung, J. ; Werner, John S ; Morgan, A. ; St. George Hyslop, P. ; Thompson, P. ; Dutton, R. ; Mlikotic, A. ; Rogaeva, E. ; Hardy, J. / An African American family with early-onset Alzheimer disease and an APP (T714I) mutation. In: Neurology. 2005 ; Vol. 64, No. 2. pp. 377-379.
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