An African American family with early-onset Alzheimer disease and an APP (T714I) mutation

T. Edwards-Lee, J. M. Ringman, J. Chung, John S Werner, A. Morgan, P. St. George Hyslop, P. Thompson, R. Dutton, A. Mlikotic, E. Rogaeva, J. Hardy

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31 Scopus citations

Abstract

The occurrence of an APP T174I mutation is described in a large American family of African descent with Alzheimer disease. The clinical characteristics were an unusually early onset of disease (early 30s), similar to a previously reported age at onset of this mutation in an Austrian family. Distinct from that family, seizures and myoclonus were prominent features of the disease in this kindred.

Original languageEnglish (US)
Pages (from-to)377-379
Number of pages3
JournalNeurology
Volume64
Issue number2
StatePublished - Jan 25 2005
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)

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    Edwards-Lee, T., Ringman, J. M., Chung, J., Werner, J. S., Morgan, A., St. George Hyslop, P., Thompson, P., Dutton, R., Mlikotic, A., Rogaeva, E., & Hardy, J. (2005). An African American family with early-onset Alzheimer disease and an APP (T714I) mutation. Neurology, 64(2), 377-379.