Amygdala reactivity to emotional faces predicts improvement in major depression

Turhan Canli, Rebecca E. Cooney, Philip R Goldin, Maulik Shah, Heidi Sivers, Moriah E. Thomason, Susan Whitfield-Gabrieli, John D E Gabriels, Ian H. Gotlib

Research output: Contribution to journalArticle

142 Scopus citations


Behavioral studies suggest that emotional reactivity in depressed persons predicts subsequent symptom reduction. Using functional magnetic resonance imaging in a prospective study, we show that greater amygdala activation to emotional facial expressions among depressed patients predicts symptom reduction 8 months later, controlling for initial depression severity and medication status. Functional magnetic resonance imaging may thus be used as a method to identify neural markers in depressed patients at risk for poor outcome.

Original languageEnglish (US)
Pages (from-to)1267-1270
Number of pages4
Issue number12
StatePublished - Aug 22 2005
Externally publishedYes



  • Affect
  • Amygdala
  • Depression
  • Imaging
  • Psychiatric outcome

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Canli, T., Cooney, R. E., Goldin, P. R., Shah, M., Sivers, H., Thomason, M. E., Whitfield-Gabrieli, S., Gabriels, J. D. E., & Gotlib, I. H. (2005). Amygdala reactivity to emotional faces predicts improvement in major depression. NeuroReport, 16(12), 1267-1270.