Amygdala reactivity to emotional faces predicts improvement in major depression

Turhan Canli; Rebecca E. Cooney; Philip R Goldin; Maulik Shah; Heidi Sivers; Moriah E. Thomason; Susan Whitfield-Gabrieli; John D E Gabriels; Ian H. Gotlib

doi:10.1097/01.wnr.0000174407.09515.cc

Amygdala reactivity to emotional faces predicts improvement in major depression

Turhan Canli, Rebecca E. Cooney, Philip R Goldin, Maulik Shah, Heidi Sivers, Moriah E. Thomason, Susan Whitfield-Gabrieli, John D E Gabriels, Ian H. Gotlib

Research output: Contribution to journal › Article › peer-review

150 Scopus citations

Abstract

Behavioral studies suggest that emotional reactivity in depressed persons predicts subsequent symptom reduction. Using functional magnetic resonance imaging in a prospective study, we show that greater amygdala activation to emotional facial expressions among depressed patients predicts symptom reduction 8 months later, controlling for initial depression severity and medication status. Functional magnetic resonance imaging may thus be used as a method to identify neural markers in depressed patients at risk for poor outcome.

Original language	English (US)
Pages (from-to)	1267-1270
Number of pages	4
Journal	NeuroReport
Volume	16
Issue number	12
DOIs	https://doi.org/10.1097/01.wnr.0000174407.09515.cc
State	Published - Aug 22 2005
Externally published	Yes

Keywords

Affect
Amygdala
Depression
Imaging
Psychiatric outcome

ASJC Scopus subject areas

Neuroscience(all)

Access to Document

10.1097/01.wnr.0000174407.09515.cc

Cite this

Amygdala reactivity to emotional faces predicts improvement in major depression. / Canli, Turhan; Cooney, Rebecca E.; Goldin, Philip R; Shah, Maulik; Sivers, Heidi; Thomason, Moriah E.; Whitfield-Gabrieli, Susan; Gabriels, John D E; Gotlib, Ian H.

In: NeuroReport, Vol. 16, No. 12, 22.08.2005, p. 1267-1270.

Research output: Contribution to journal › Article › peer-review

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AU - Thomason, Moriah E.

AU - Whitfield-Gabrieli, Susan

AU - Gabriels, John D E

AU - Gotlib, Ian H.

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AB - Behavioral studies suggest that emotional reactivity in depressed persons predicts subsequent symptom reduction. Using functional magnetic resonance imaging in a prospective study, we show that greater amygdala activation to emotional facial expressions among depressed patients predicts symptom reduction 8 months later, controlling for initial depression severity and medication status. Functional magnetic resonance imaging may thus be used as a method to identify neural markers in depressed patients at risk for poor outcome.

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KW - Psychiatric outcome

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Amygdala reactivity to emotional faces predicts improvement in major depression

Abstract

Keywords

ASJC Scopus subject areas

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