Abstract
Behavioral studies suggest that emotional reactivity in depressed persons predicts subsequent symptom reduction. Using functional magnetic resonance imaging in a prospective study, we show that greater amygdala activation to emotional facial expressions among depressed patients predicts symptom reduction 8 months later, controlling for initial depression severity and medication status. Functional magnetic resonance imaging may thus be used as a method to identify neural markers in depressed patients at risk for poor outcome.
Original language | English (US) |
---|---|
Pages (from-to) | 1267-1270 |
Number of pages | 4 |
Journal | NeuroReport |
Volume | 16 |
Issue number | 12 |
DOIs | |
State | Published - Aug 22 2005 |
Externally published | Yes |
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Keywords
- Affect
- Amygdala
- Depression
- Imaging
- Psychiatric outcome
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Amygdala reactivity to emotional faces predicts improvement in major depression. / Canli, Turhan; Cooney, Rebecca E.; Goldin, Philip R; Shah, Maulik; Sivers, Heidi; Thomason, Moriah E.; Whitfield-Gabrieli, Susan; Gabriels, John D E; Gotlib, Ian H.
In: NeuroReport, Vol. 16, No. 12, 22.08.2005, p. 1267-1270.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Amygdala reactivity to emotional faces predicts improvement in major depression
AU - Canli, Turhan
AU - Cooney, Rebecca E.
AU - Goldin, Philip R
AU - Shah, Maulik
AU - Sivers, Heidi
AU - Thomason, Moriah E.
AU - Whitfield-Gabrieli, Susan
AU - Gabriels, John D E
AU - Gotlib, Ian H.
PY - 2005/8/22
Y1 - 2005/8/22
N2 - Behavioral studies suggest that emotional reactivity in depressed persons predicts subsequent symptom reduction. Using functional magnetic resonance imaging in a prospective study, we show that greater amygdala activation to emotional facial expressions among depressed patients predicts symptom reduction 8 months later, controlling for initial depression severity and medication status. Functional magnetic resonance imaging may thus be used as a method to identify neural markers in depressed patients at risk for poor outcome.
AB - Behavioral studies suggest that emotional reactivity in depressed persons predicts subsequent symptom reduction. Using functional magnetic resonance imaging in a prospective study, we show that greater amygdala activation to emotional facial expressions among depressed patients predicts symptom reduction 8 months later, controlling for initial depression severity and medication status. Functional magnetic resonance imaging may thus be used as a method to identify neural markers in depressed patients at risk for poor outcome.
KW - Affect
KW - Amygdala
KW - Depression
KW - Imaging
KW - Psychiatric outcome
UR - http://www.scopus.com/inward/record.url?scp=24044549049&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=24044549049&partnerID=8YFLogxK
U2 - 10.1097/01.wnr.0000174407.09515.cc
DO - 10.1097/01.wnr.0000174407.09515.cc
M3 - Article
C2 - 16056122
AN - SCOPUS:24044549049
VL - 16
SP - 1267
EP - 1270
JO - NeuroReport
JF - NeuroReport
SN - 0959-4965
IS - 12
ER -