Amygdala reactivity to emotional faces predicts improvement in major depression

Turhan Canli, Rebecca E. Cooney, Philip R Goldin, Maulik Shah, Heidi Sivers, Moriah E. Thomason, Susan Whitfield-Gabrieli, John D E Gabriels, Ian H. Gotlib

Research output: Contribution to journalArticle

142 Citations (Scopus)

Abstract

Behavioral studies suggest that emotional reactivity in depressed persons predicts subsequent symptom reduction. Using functional magnetic resonance imaging in a prospective study, we show that greater amygdala activation to emotional facial expressions among depressed patients predicts symptom reduction 8 months later, controlling for initial depression severity and medication status. Functional magnetic resonance imaging may thus be used as a method to identify neural markers in depressed patients at risk for poor outcome.

Original languageEnglish (US)
Pages (from-to)1267-1270
Number of pages4
JournalNeuroReport
Volume16
Issue number12
DOIs
StatePublished - Aug 22 2005
Externally publishedYes

Fingerprint

Amygdala
Magnetic Resonance Imaging
Depression
Facial Expression
Prospective Studies

Keywords

  • Affect
  • Amygdala
  • Depression
  • Imaging
  • Psychiatric outcome

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Canli, T., Cooney, R. E., Goldin, P. R., Shah, M., Sivers, H., Thomason, M. E., ... Gotlib, I. H. (2005). Amygdala reactivity to emotional faces predicts improvement in major depression. NeuroReport, 16(12), 1267-1270. https://doi.org/10.1097/01.wnr.0000174407.09515.cc

Amygdala reactivity to emotional faces predicts improvement in major depression. / Canli, Turhan; Cooney, Rebecca E.; Goldin, Philip R; Shah, Maulik; Sivers, Heidi; Thomason, Moriah E.; Whitfield-Gabrieli, Susan; Gabriels, John D E; Gotlib, Ian H.

In: NeuroReport, Vol. 16, No. 12, 22.08.2005, p. 1267-1270.

Research output: Contribution to journalArticle

Canli, T, Cooney, RE, Goldin, PR, Shah, M, Sivers, H, Thomason, ME, Whitfield-Gabrieli, S, Gabriels, JDE & Gotlib, IH 2005, 'Amygdala reactivity to emotional faces predicts improvement in major depression', NeuroReport, vol. 16, no. 12, pp. 1267-1270. https://doi.org/10.1097/01.wnr.0000174407.09515.cc
Canli, Turhan ; Cooney, Rebecca E. ; Goldin, Philip R ; Shah, Maulik ; Sivers, Heidi ; Thomason, Moriah E. ; Whitfield-Gabrieli, Susan ; Gabriels, John D E ; Gotlib, Ian H. / Amygdala reactivity to emotional faces predicts improvement in major depression. In: NeuroReport. 2005 ; Vol. 16, No. 12. pp. 1267-1270.
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