Abstract
Behavioral studies suggest that emotional reactivity in depressed persons predicts subsequent symptom reduction. Using functional magnetic resonance imaging in a prospective study, we show that greater amygdala activation to emotional facial expressions among depressed patients predicts symptom reduction 8 months later, controlling for initial depression severity and medication status. Functional magnetic resonance imaging may thus be used as a method to identify neural markers in depressed patients at risk for poor outcome.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1267-1270 |
| Number of pages | 4 |
| Journal | NeuroReport |
| Volume | 16 |
| Issue number | 12 |
| DOIs | |
| State | Published - Aug 22 2005 |
| Externally published | Yes |
Keywords
- Affect
- Amygdala
- Depression
- Imaging
- Psychiatric outcome
ASJC Scopus subject areas
- Neuroscience(all)
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Cite this
Canli, T., Cooney, R. E., Goldin, P. R., Shah, M., Sivers, H., Thomason, M. E., Whitfield-Gabrieli, S., Gabriels, J. D. E., & Gotlib, I. H. (2005). Amygdala reactivity to emotional faces predicts improvement in major depression. NeuroReport, 16(12), 1267-1270. https://doi.org/10.1097/01.wnr.0000174407.09515.cc