Amygdala reactivity to emotional faces predicts improvement in major depression

Turhan Canli; Rebecca E. Cooney; Philip R Goldin; Maulik Shah; Heidi Sivers; Moriah E. Thomason; Susan Whitfield-Gabrieli; John D E Gabriels; Ian H. Gotlib

doi:10.1097/01.wnr.0000174407.09515.cc

Amygdala reactivity to emotional faces predicts improvement in major depression

Turhan Canli, Rebecca E. Cooney, Philip R Goldin, Maulik Shah, Heidi Sivers, Moriah E. Thomason, Susan Whitfield-Gabrieli, John D E Gabriels, Ian H. Gotlib

Research output: Contribution to journal › Article

142 Scopus citations

Abstract

Behavioral studies suggest that emotional reactivity in depressed persons predicts subsequent symptom reduction. Using functional magnetic resonance imaging in a prospective study, we show that greater amygdala activation to emotional facial expressions among depressed patients predicts symptom reduction 8 months later, controlling for initial depression severity and medication status. Functional magnetic resonance imaging may thus be used as a method to identify neural markers in depressed patients at risk for poor outcome.

Original language	English (US)
Pages (from-to)	1267-1270
Number of pages	4
Journal	NeuroReport
Volume	16
Issue number	12
DOIs	https://doi.org/10.1097/01.wnr.0000174407.09515.cc
State	Published - Aug 22 2005
Externally published	Yes

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Keywords

Affect
Amygdala
Depression
Imaging
Psychiatric outcome

ASJC Scopus subject areas

Neuroscience(all)

Cite this

Canli, T., Cooney, R. E., Goldin, P. R., Shah, M., Sivers, H., Thomason, M. E., Whitfield-Gabrieli, S., Gabriels, J. D. E., & Gotlib, I. H. (2005). Amygdala reactivity to emotional faces predicts improvement in major depression. NeuroReport, 16(12), 1267-1270. https://doi.org/10.1097/01.wnr.0000174407.09515.cc

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10.1097/01.wnr.0000174407.09515.cc