Amygdala-kindled postictal inhibition: Effect of intertrial intervals on repeated days

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Fully amygdala-kindled rats with stable afterdischarge durations and seizure ranks of five were evaluated with suprathreshold stimulations (400 μA) at variable interstimulus intervals. Subjects were stimulated either once a day or four times a day at one of five interstimulus intervals (5, 15, 30, 60, or 180 min) for 5 days. All subjects were tested under each of the six paradigms. Profound inhibition of seizure rank and afterdischarge duration occurred daily with intertrial stimulation times of 30 min or less. The initial stimulations each day at these intertrial intervals showed no significant residual inhibition from the stimulations of the previous day. The longer intertrial intervals of 60 and 180 min demonstrated little inhibition of elicited seizures on day 1 for trials 2 through 4; however, after the 1st day, increased inhibition was noted for trials 2 through 4 at the 60-min intertrial interval with relatively little inhibition noted for the first trial of each day at this interval. At the longest interval tested (180 min), a significant (P <- 0.05) reduction in both the seizure rank and after discharge duration was noted with the first elicited seizure of days 3 through 5. At the 180-min interval, seizures 2 through 4 on days 3 through 5 tended to increase in length and severity rather than decrease compared with the first seizure of the day. Significant interactions occurred between the length of intertrial interval used with multiple stimulation paradigms and repeated days of testing. The short-term inhibition seen with shorter intertrial interval testing interacted in a complex and poorly understood manner with the longer term inhibition associated with daily grouped stimulations in the amygdala-kindled model of epilepsy.

Original languageEnglish (US)
Pages (from-to)197-206
Number of pages10
JournalExperimental Neurology
Volume92
Issue number1
DOIs
StatePublished - 1986

Fingerprint

Amygdala
Seizures
Epilepsy

ASJC Scopus subject areas

  • Neuroscience(all)
  • Neurology

Cite this

Amygdala-kindled postictal inhibition : Effect of intertrial intervals on repeated days. / Albertson, Timothy E.

In: Experimental Neurology, Vol. 92, No. 1, 1986, p. 197-206.

Research output: Contribution to journalArticle

@article{0c3c779af0a24b88a6849c11dea1fc80,
title = "Amygdala-kindled postictal inhibition: Effect of intertrial intervals on repeated days",
abstract = "Fully amygdala-kindled rats with stable afterdischarge durations and seizure ranks of five were evaluated with suprathreshold stimulations (400 μA) at variable interstimulus intervals. Subjects were stimulated either once a day or four times a day at one of five interstimulus intervals (5, 15, 30, 60, or 180 min) for 5 days. All subjects were tested under each of the six paradigms. Profound inhibition of seizure rank and afterdischarge duration occurred daily with intertrial stimulation times of 30 min or less. The initial stimulations each day at these intertrial intervals showed no significant residual inhibition from the stimulations of the previous day. The longer intertrial intervals of 60 and 180 min demonstrated little inhibition of elicited seizures on day 1 for trials 2 through 4; however, after the 1st day, increased inhibition was noted for trials 2 through 4 at the 60-min intertrial interval with relatively little inhibition noted for the first trial of each day at this interval. At the longest interval tested (180 min), a significant (P <- 0.05) reduction in both the seizure rank and after discharge duration was noted with the first elicited seizure of days 3 through 5. At the 180-min interval, seizures 2 through 4 on days 3 through 5 tended to increase in length and severity rather than decrease compared with the first seizure of the day. Significant interactions occurred between the length of intertrial interval used with multiple stimulation paradigms and repeated days of testing. The short-term inhibition seen with shorter intertrial interval testing interacted in a complex and poorly understood manner with the longer term inhibition associated with daily grouped stimulations in the amygdala-kindled model of epilepsy.",
author = "Albertson, {Timothy E}",
year = "1986",
doi = "10.1016/0014-4886(86)90134-2",
language = "English (US)",
volume = "92",
pages = "197--206",
journal = "Experimental Neurology",
issn = "0014-4886",
publisher = "Academic Press Inc.",
number = "1",

}

TY - JOUR

T1 - Amygdala-kindled postictal inhibition

T2 - Effect of intertrial intervals on repeated days

AU - Albertson, Timothy E

PY - 1986

Y1 - 1986

N2 - Fully amygdala-kindled rats with stable afterdischarge durations and seizure ranks of five were evaluated with suprathreshold stimulations (400 μA) at variable interstimulus intervals. Subjects were stimulated either once a day or four times a day at one of five interstimulus intervals (5, 15, 30, 60, or 180 min) for 5 days. All subjects were tested under each of the six paradigms. Profound inhibition of seizure rank and afterdischarge duration occurred daily with intertrial stimulation times of 30 min or less. The initial stimulations each day at these intertrial intervals showed no significant residual inhibition from the stimulations of the previous day. The longer intertrial intervals of 60 and 180 min demonstrated little inhibition of elicited seizures on day 1 for trials 2 through 4; however, after the 1st day, increased inhibition was noted for trials 2 through 4 at the 60-min intertrial interval with relatively little inhibition noted for the first trial of each day at this interval. At the longest interval tested (180 min), a significant (P <- 0.05) reduction in both the seizure rank and after discharge duration was noted with the first elicited seizure of days 3 through 5. At the 180-min interval, seizures 2 through 4 on days 3 through 5 tended to increase in length and severity rather than decrease compared with the first seizure of the day. Significant interactions occurred between the length of intertrial interval used with multiple stimulation paradigms and repeated days of testing. The short-term inhibition seen with shorter intertrial interval testing interacted in a complex and poorly understood manner with the longer term inhibition associated with daily grouped stimulations in the amygdala-kindled model of epilepsy.

AB - Fully amygdala-kindled rats with stable afterdischarge durations and seizure ranks of five were evaluated with suprathreshold stimulations (400 μA) at variable interstimulus intervals. Subjects were stimulated either once a day or four times a day at one of five interstimulus intervals (5, 15, 30, 60, or 180 min) for 5 days. All subjects were tested under each of the six paradigms. Profound inhibition of seizure rank and afterdischarge duration occurred daily with intertrial stimulation times of 30 min or less. The initial stimulations each day at these intertrial intervals showed no significant residual inhibition from the stimulations of the previous day. The longer intertrial intervals of 60 and 180 min demonstrated little inhibition of elicited seizures on day 1 for trials 2 through 4; however, after the 1st day, increased inhibition was noted for trials 2 through 4 at the 60-min intertrial interval with relatively little inhibition noted for the first trial of each day at this interval. At the longest interval tested (180 min), a significant (P <- 0.05) reduction in both the seizure rank and after discharge duration was noted with the first elicited seizure of days 3 through 5. At the 180-min interval, seizures 2 through 4 on days 3 through 5 tended to increase in length and severity rather than decrease compared with the first seizure of the day. Significant interactions occurred between the length of intertrial interval used with multiple stimulation paradigms and repeated days of testing. The short-term inhibition seen with shorter intertrial interval testing interacted in a complex and poorly understood manner with the longer term inhibition associated with daily grouped stimulations in the amygdala-kindled model of epilepsy.

UR - http://www.scopus.com/inward/record.url?scp=0022579441&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022579441&partnerID=8YFLogxK

U2 - 10.1016/0014-4886(86)90134-2

DO - 10.1016/0014-4886(86)90134-2

M3 - Article

C2 - 3956649

AN - SCOPUS:0022579441

VL - 92

SP - 197

EP - 206

JO - Experimental Neurology

JF - Experimental Neurology

SN - 0014-4886

IS - 1

ER -