Amygdala Enlargement in Toddlers with Autism Related to Severity of Social and Communication Impairments

Cynthia Schumann, Cynthia Carter Barnes, Catherine Lord, Eric Courchesne

Research output: Contribution to journalArticle

172 Citations (Scopus)

Abstract

Background: Autism is a heterogeneous neurodevelopmental disorder of unknown etiology. The amygdala has long been a site of intense interest in the search for neuropathology in autism, given its role in emotional and social behavior. An interesting hypothesis has emerged that the amygdala undergoes an abnormal developmental trajectory with a period of early overgrowth in autism; however this finding has not been well established at young ages nor analyzed with boys and girls independently. Methods: We measured amygdala volumes on magnetic resonance imaging scans from 89 toddlers at 1-5 years of age (mean = 3 years). Each child returned at ∼5 years of age for final clinical evaluation. Results: Toddlers who later received a confirmed autism diagnosis (32 boys, 9 girls) had a larger right (p < .01) and left (p < .05) amygdala compared with typically developing toddlers (28 boys, 11 girls) with and without covarying for total cerebral volume. Amygdala size in toddlers with autism spectrum disorder correlated with the severity of their social and communication impairments as measured on the Autism Diagnostic Interview and Vineland scale. Strikingly, girls differed more robustly from typical in amygdala volume, whereas boys accounted for the significant relationship of amygdala size with severity of clinical impairment. Conclusions: This study provides evidence that the amygdala is enlarged in young children with autism; the overgrowth must begin before 3 years of age and is associated with the severity of clinical impairments. However, neuroanatomic phenotypic profiles differ between males and females, which critically affects future studies on the genetics and etiology of autism.

Original languageEnglish (US)
Pages (from-to)942-949
Number of pages8
JournalBiological Psychiatry
Volume66
Issue number10
DOIs
StatePublished - Nov 15 2009

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Autistic Disorder
Amygdala
Communication
Social Behavior
Magnetic Resonance Imaging
Interviews

Keywords

  • Brain growth
  • development
  • MRI
  • neuroanatomy
  • temporal
  • volume

ASJC Scopus subject areas

  • Biological Psychiatry

Cite this

Amygdala Enlargement in Toddlers with Autism Related to Severity of Social and Communication Impairments. / Schumann, Cynthia; Barnes, Cynthia Carter; Lord, Catherine; Courchesne, Eric.

In: Biological Psychiatry, Vol. 66, No. 10, 15.11.2009, p. 942-949.

Research output: Contribution to journalArticle

Schumann, Cynthia ; Barnes, Cynthia Carter ; Lord, Catherine ; Courchesne, Eric. / Amygdala Enlargement in Toddlers with Autism Related to Severity of Social and Communication Impairments. In: Biological Psychiatry. 2009 ; Vol. 66, No. 10. pp. 942-949.
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