Amnesia attenuation specificity: Propranolol reverses norepinephrine but not cycloheximide-induced amnesia

Maureen E. Ellis, Robert F Berman, Raymond P. Kesner

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Post-trial injections of norepinephrine (NE) or cycloheximide (CHX) into the amygdala produces a long-term retention deficit (amnesia) for a 1-trial footshock experience in rats. Concomitant post-trial injections of the adrenergic antagonist, propranolol, prevents NE-, but not CHX-induced amnesia. These results indicate separate mechanisms of action for amnesia produced by intracranial CHX and NE injections.

Original languageEnglish (US)
Pages (from-to)733-736
Number of pages4
JournalPharmacology, Biochemistry and Behavior
Volume19
Issue number5
DOIs
StatePublished - 1983
Externally publishedYes

Keywords

  • Amnesia
  • Amygdala
  • Aversive information processing
  • Cycloheximide
  • Differential attenuation
  • Memory mechanisms
  • Norepinephrine
  • Propranolol

ASJC Scopus subject areas

  • Biochemistry
  • Behavioral Neuroscience
  • Pharmacology

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