Amnesia attenuation specificity: Propranolol reverses norepinephrine but not cycloheximide-induced amnesia

Maureen E. Ellis; Robert F Berman; Raymond P. Kesner

doi:10.1016/0091-3057(83)90071-0

Amnesia attenuation specificity: Propranolol reverses norepinephrine but not cycloheximide-induced amnesia

Maureen E. Ellis, Robert F Berman, Raymond P. Kesner

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Post-trial injections of norepinephrine (NE) or cycloheximide (CHX) into the amygdala produces a long-term retention deficit (amnesia) for a 1-trial footshock experience in rats. Concomitant post-trial injections of the adrenergic antagonist, propranolol, prevents NE-, but not CHX-induced amnesia. These results indicate separate mechanisms of action for amnesia produced by intracranial CHX and NE injections.

Original language	English (US)
Pages (from-to)	733-736
Number of pages	4
Journal	Pharmacology, Biochemistry and Behavior
Volume	19
Issue number	5
DOIs	https://doi.org/10.1016/0091-3057(83)90071-0
State	Published - 1983
Externally published	Yes

Keywords

Amnesia
Amygdala
Aversive information processing
Cycloheximide
Differential attenuation
Memory mechanisms
Norepinephrine
Propranolol

ASJC Scopus subject areas

Biochemistry
Behavioral Neuroscience
Pharmacology

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10.1016/0091-3057(83)90071-0

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title = "Amnesia attenuation specificity: Propranolol reverses norepinephrine but not cycloheximide-induced amnesia",

abstract = "Post-trial injections of norepinephrine (NE) or cycloheximide (CHX) into the amygdala produces a long-term retention deficit (amnesia) for a 1-trial footshock experience in rats. Concomitant post-trial injections of the adrenergic antagonist, propranolol, prevents NE-, but not CHX-induced amnesia. These results indicate separate mechanisms of action for amnesia produced by intracranial CHX and NE injections.",

keywords = "Amnesia, Amygdala, Aversive information processing, Cycloheximide, Differential attenuation, Memory mechanisms, Norepinephrine, Propranolol",

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year = "1983",

doi = "10.1016/0091-3057(83)90071-0",

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T2 - Propranolol reverses norepinephrine but not cycloheximide-induced amnesia

AU - Ellis, Maureen E.

AU - Berman, Robert F

AU - Kesner, Raymond P.

PY - 1983

Y1 - 1983

N2 - Post-trial injections of norepinephrine (NE) or cycloheximide (CHX) into the amygdala produces a long-term retention deficit (amnesia) for a 1-trial footshock experience in rats. Concomitant post-trial injections of the adrenergic antagonist, propranolol, prevents NE-, but not CHX-induced amnesia. These results indicate separate mechanisms of action for amnesia produced by intracranial CHX and NE injections.

AB - Post-trial injections of norepinephrine (NE) or cycloheximide (CHX) into the amygdala produces a long-term retention deficit (amnesia) for a 1-trial footshock experience in rats. Concomitant post-trial injections of the adrenergic antagonist, propranolol, prevents NE-, but not CHX-induced amnesia. These results indicate separate mechanisms of action for amnesia produced by intracranial CHX and NE injections.

KW - Amnesia

KW - Amygdala

KW - Aversive information processing

KW - Cycloheximide

KW - Differential attenuation

KW - Memory mechanisms

KW - Norepinephrine

KW - Propranolol

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JO - Pharmacology Biochemistry and Behavior

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SN - 0091-3057

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ER -

Amnesia attenuation specificity: Propranolol reverses norepinephrine but not cycloheximide-induced amnesia

Abstract

Keywords

ASJC Scopus subject areas

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