Abstract
Post-trial injections of norepinephrine (NE) or cycloheximide (CHX) into the amygdala produces a long-term retention deficit (amnesia) for a 1-trial footshock experience in rats. Concomitant post-trial injections of the adrenergic antagonist, propranolol, prevents NE-, but not CHX-induced amnesia. These results indicate separate mechanisms of action for amnesia produced by intracranial CHX and NE injections.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 733-736 |
| Number of pages | 4 |
| Journal | Pharmacology, Biochemistry and Behavior |
| Volume | 19 |
| Issue number | 5 |
| DOIs | |
| State | Published - 1983 |
| Externally published | Yes |
Keywords
- Amnesia
- Amygdala
- Aversive information processing
- Cycloheximide
- Differential attenuation
- Memory mechanisms
- Norepinephrine
- Propranolol
ASJC Scopus subject areas
- Biochemistry
- Behavioral Neuroscience
- Pharmacology
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Cite this
Ellis, M. E., Berman, R. F., & Kesner, R. P. (1983). Amnesia attenuation specificity: Propranolol reverses norepinephrine but not cycloheximide-induced amnesia. Pharmacology, Biochemistry and Behavior, 19(5), 733-736. https://doi.org/10.1016/0091-3057(83)90071-0