Ammonia intoxication in the near-adult cat as a result of a dietary deficiency of arginine

James Morris; Quinton Rogers

doi:10.1126/science.619464

Ammonia intoxication in the near-adult cat as a result of a dietary deficiency of arginine

James Morris, Quinton Rogers

School of Veterinary Medicine

Research output: Contribution to journal › Article › peer-review

78 Scopus citations

Abstract

Near-adult cats, fasted overnight, and given a single meal ofa complete amino acid diet without arginine, developed hyperammonemia and showed clinical symptoms of ammonia toxicity within 2 hours. One cat (2.7 kilograms) died 4.5 hours after ingesting only 8 grams of the diet. Since ornithine also prevented hyperammonemia, it appears that the domestic cat cannot synthesize ornithine.

Original language	English (US)
Pages (from-to)	431-432
Number of pages	2
Journal	Science
Volume	199
Issue number	4327
DOIs	https://doi.org/10.1126/science.619464
State	Published - Jan 1 1978

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title = "Ammonia intoxication in the near-adult cat as a result of a dietary deficiency of arginine",

abstract = "Near-adult cats, fasted overnight, and given a single meal ofa complete amino acid diet without arginine, developed hyperammonemia and showed clinical symptoms of ammonia toxicity within 2 hours. One cat (2.7 kilograms) died 4.5 hours after ingesting only 8 grams of the diet. Since ornithine also prevented hyperammonemia, it appears that the domestic cat cannot synthesize ornithine.",

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