TY - JOUR
T1 - Amino acid neurotransmission
T2 - spotlight on synaptic vesicles
AU - Maycox, Peter R.
AU - Hell, Johannes W
AU - Jahn, Reinhard
PY - 1990
Y1 - 1990
N2 - The vesicle hypothesis describing quantal release of neurotransmitter at the cholinergic neuromuscular junction was introduced in 19561. Since then, the concept of vesicular storage and release of acetylcholine has become firmly established2,3 and extended to include other synapses and neurotransmitters4. However, for the amino acids, which are the major class of neurotransmitters in the mammalian CNS, there was no direct experimental evidence of the participation of synaptic vesicles in neurotransmission. This area of research has now moved out of the shadows and this article discusses recent findings which indicate that amino acid neurotransmitters are accumulated and stored by synaptic vesicles in presynaptic nerve endings.
AB - The vesicle hypothesis describing quantal release of neurotransmitter at the cholinergic neuromuscular junction was introduced in 19561. Since then, the concept of vesicular storage and release of acetylcholine has become firmly established2,3 and extended to include other synapses and neurotransmitters4. However, for the amino acids, which are the major class of neurotransmitters in the mammalian CNS, there was no direct experimental evidence of the participation of synaptic vesicles in neurotransmission. This area of research has now moved out of the shadows and this article discusses recent findings which indicate that amino acid neurotransmitters are accumulated and stored by synaptic vesicles in presynaptic nerve endings.
UR - http://www.scopus.com/inward/record.url?scp=0025021999&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025021999&partnerID=8YFLogxK
U2 - 10.1016/0166-2236(90)90178-D
DO - 10.1016/0166-2236(90)90178-D
M3 - Article
C2 - 1691873
AN - SCOPUS:0025021999
VL - 13
SP - 83
EP - 87
JO - Trends in Neurosciences
JF - Trends in Neurosciences
SN - 0378-5912
IS - 3
ER -