Ameloblastoma of the Jaw in Three Species of Rodent: a Domestic Brown Rat (Rattus norvegicus), Syrian Hamster (Mesocricetus auratus) and Amargosa Vole (Microtus californicus scirpensis)

Brian G Murphy, A. Michel, E. B. LaDouceur, C. Bell, M. Lin, Denise Imai

Research output: Contribution to journalArticle

Abstract

Ameloblastoma is a locally aggressive tumour derived from the odontogenic epithelium of the developing tooth germ. This uncommon odontogenic tumour is generally considered benign, but rarely, both distant metastasis and cytological atypia occur and this malignant version is referred to as malignant ameloblastic carcinoma. Here we document a spontaneous malignant ameloblastic carcinoma in a rat (Rattus norvegicus) with metastasis to the submandibular lymph node. We also describe ameloblastomas in two other muroid rodents, an Amaragosa vole (Microtus californicus scirpensis) and a Syrian hamster (Mesocricetus auratus). To our knowledge, this is the first report of a malignant ameloblastic carcinoma in any animal and the first report of ameloblastoma in a vole and hamster.

Original languageEnglish (US)
Pages (from-to)145-149
Number of pages5
JournalJournal of Comparative Pathology
Volume157
Issue number2-3
DOIs
StatePublished - Aug 1 2017

Fingerprint

Ameloblastoma
Arvicolinae
Rattus norvegicus
Mesocricetus
Jaw
jaws
Odontogenic Tumors
Rodentia
rodents
carcinoma
Carcinoma
rats
metastasis
Tooth Germ
Neoplasm Metastasis
Cricetinae
Epithelium
Lymph Nodes
hamsters
lymph nodes

Keywords

  • ameloblastic carcinoma
  • ameloblastoma
  • mandible
  • rodent

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • veterinary(all)

Cite this

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title = "Ameloblastoma of the Jaw in Three Species of Rodent: a Domestic Brown Rat (Rattus norvegicus), Syrian Hamster (Mesocricetus auratus) and Amargosa Vole (Microtus californicus scirpensis)",
abstract = "Ameloblastoma is a locally aggressive tumour derived from the odontogenic epithelium of the developing tooth germ. This uncommon odontogenic tumour is generally considered benign, but rarely, both distant metastasis and cytological atypia occur and this malignant version is referred to as malignant ameloblastic carcinoma. Here we document a spontaneous malignant ameloblastic carcinoma in a rat (Rattus norvegicus) with metastasis to the submandibular lymph node. We also describe ameloblastomas in two other muroid rodents, an Amaragosa vole (Microtus californicus scirpensis) and a Syrian hamster (Mesocricetus auratus). To our knowledge, this is the first report of a malignant ameloblastic carcinoma in any animal and the first report of ameloblastoma in a vole and hamster.",
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T2 - a Domestic Brown Rat (Rattus norvegicus), Syrian Hamster (Mesocricetus auratus) and Amargosa Vole (Microtus californicus scirpensis)

AU - Murphy, Brian G

AU - Michel, A.

AU - LaDouceur, E. B.

AU - Bell, C.

AU - Lin, M.

AU - Imai, Denise

PY - 2017/8/1

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N2 - Ameloblastoma is a locally aggressive tumour derived from the odontogenic epithelium of the developing tooth germ. This uncommon odontogenic tumour is generally considered benign, but rarely, both distant metastasis and cytological atypia occur and this malignant version is referred to as malignant ameloblastic carcinoma. Here we document a spontaneous malignant ameloblastic carcinoma in a rat (Rattus norvegicus) with metastasis to the submandibular lymph node. We also describe ameloblastomas in two other muroid rodents, an Amaragosa vole (Microtus californicus scirpensis) and a Syrian hamster (Mesocricetus auratus). To our knowledge, this is the first report of a malignant ameloblastic carcinoma in any animal and the first report of ameloblastoma in a vole and hamster.

AB - Ameloblastoma is a locally aggressive tumour derived from the odontogenic epithelium of the developing tooth germ. This uncommon odontogenic tumour is generally considered benign, but rarely, both distant metastasis and cytological atypia occur and this malignant version is referred to as malignant ameloblastic carcinoma. Here we document a spontaneous malignant ameloblastic carcinoma in a rat (Rattus norvegicus) with metastasis to the submandibular lymph node. We also describe ameloblastomas in two other muroid rodents, an Amaragosa vole (Microtus californicus scirpensis) and a Syrian hamster (Mesocricetus auratus). To our knowledge, this is the first report of a malignant ameloblastic carcinoma in any animal and the first report of ameloblastoma in a vole and hamster.

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