Ameloblastic carcinoma in a horse

H. E V De Cock, P. Labelle, K G Magdesian

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Abstract

The clinical, gross morphological, histological and immunohistochemical characteristics of an ameloblastic carcinoma in a 30-year-old Quarter Horse mare are reported. This tumour was fast growing, locally invasive and destructive. Histologically, it showed an infiltrative pattern of large islands, broad sheets and, at the periphery, small cords of moderately pleomorphic round, oval to spindle-shaped cells. Immunohistochemical evaluation revealed positive labelling for vimentin, cytokeratin 5/6 and cytokeratin 14. In the oral cavity of human beings, this immunolabelling pattern is unique for the embryonal enamel organ and tumours of ameloblastomatous epithelial origin, which strongly supports the diagnosis of equine ameloblastic carcinoma.

Original languageEnglish (US)
Pages (from-to)210-215
Number of pages6
JournalJournal of Comparative Pathology
Volume128
Issue number2-3
DOIs
StatePublished - Feb 2003

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ASJC Scopus subject areas

  • Animal Science and Zoology

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