Abstract
The clinical, gross morphological, histological and immunohistochemical characteristics of an ameloblastic carcinoma in a 30-year-old Quarter Horse mare are reported. This tumour was fast growing, locally invasive and destructive. Histologically, it showed an infiltrative pattern of large islands, broad sheets and, at the periphery, small cords of moderately pleomorphic round, oval to spindle-shaped cells. Immunohistochemical evaluation revealed positive labelling for vimentin, cytokeratin 5/6 and cytokeratin 14. In the oral cavity of human beings, this immunolabelling pattern is unique for the embryonal enamel organ and tumours of ameloblastomatous epithelial origin, which strongly supports the diagnosis of equine ameloblastic carcinoma.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 210-215 |
| Number of pages | 6 |
| Journal | Journal of Comparative Pathology |
| Volume | 128 |
| Issue number | 2-3 |
| DOIs | |
| State | Published - Feb 2003 |
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ASJC Scopus subject areas
- Animal Science and Zoology
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Ameloblastic carcinoma in a horse. / De Cock, H. E V; Labelle, P.; Magdesian, K G.
In: Journal of Comparative Pathology, Vol. 128, No. 2-3, 02.2003, p. 210-215.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Ameloblastic carcinoma in a horse
AU - De Cock, H. E V
AU - Labelle, P.
AU - Magdesian, K G
PY - 2003/2
Y1 - 2003/2
N2 - The clinical, gross morphological, histological and immunohistochemical characteristics of an ameloblastic carcinoma in a 30-year-old Quarter Horse mare are reported. This tumour was fast growing, locally invasive and destructive. Histologically, it showed an infiltrative pattern of large islands, broad sheets and, at the periphery, small cords of moderately pleomorphic round, oval to spindle-shaped cells. Immunohistochemical evaluation revealed positive labelling for vimentin, cytokeratin 5/6 and cytokeratin 14. In the oral cavity of human beings, this immunolabelling pattern is unique for the embryonal enamel organ and tumours of ameloblastomatous epithelial origin, which strongly supports the diagnosis of equine ameloblastic carcinoma.
AB - The clinical, gross morphological, histological and immunohistochemical characteristics of an ameloblastic carcinoma in a 30-year-old Quarter Horse mare are reported. This tumour was fast growing, locally invasive and destructive. Histologically, it showed an infiltrative pattern of large islands, broad sheets and, at the periphery, small cords of moderately pleomorphic round, oval to spindle-shaped cells. Immunohistochemical evaluation revealed positive labelling for vimentin, cytokeratin 5/6 and cytokeratin 14. In the oral cavity of human beings, this immunolabelling pattern is unique for the embryonal enamel organ and tumours of ameloblastomatous epithelial origin, which strongly supports the diagnosis of equine ameloblastic carcinoma.
UR - http://www.scopus.com/inward/record.url?scp=0037330140&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037330140&partnerID=8YFLogxK
U2 - 10.1053/jcpa.2002.0623
DO - 10.1053/jcpa.2002.0623
M3 - Article
C2 - 12634103
AN - SCOPUS:0037330140
VL - 128
SP - 210
EP - 215
JO - Journal of Comparative Pathology
JF - Journal of Comparative Pathology
SN - 0021-9975
IS - 2-3
ER -