Amelioration of bleomycin-induced lung fibrosis in hamsters by dietary supplementation with taurine and niacin

Biochemical mechanisms

S. N. Giri, R. Blaisdell, R. B. Rucker, Q. Wang, D. M. Hyde

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Interstitial pulmonary fibrosis induced by intratracheal instillation of bleomycin (BL) involves an excess production of reactive oxygen species, unavailability of adequate levels of NAD and ATP to repair the injured pulmonary epithelium, and an overexuberant lung collagen reactivity followed by deposition of highly cross-linked mature collagen fibrils resistant to enzymatic degradation. In the present study, we have demonstrated that dietary supplementation with taurine and niacin offered almost complete protection against the lung fibrosis in a multidose BL hamster model. The mechanisms for the protective effect of taurine and niacin are multifaceted. These include the ability of taurine to scavenge HOCl and stabilize the biomembrane; niacin's ability to replenish the BL-induced depletion of NAD and ATP; and the combined effect of taurine and niacin to suppress all aspects of BL-induced increases in the lung collagen reactivity, a hallmark of interstitial pulmonary fibrosis. It was concluded from the data presented at this Conference that the combined treatment with taurine and niacin, which offers a multipronged approach, will have great therapeutic potential in the intervention of the development of chemically induced interstitial lung fibrosis in animals and humans.

Original languageEnglish (US)
Pages (from-to)137-147
Number of pages11
JournalEnvironmental Health Perspectives
Volume102
Issue numberSUPPL. 10
StatePublished - 1994

Fingerprint

collagen
Niacin
Taurine
Bleomycin
Dietary Supplements
Cricetinae
remediation
Fibrosis
Lung
Collagen
Pulmonary Fibrosis
NAD
Adenosine Triphosphate
repair
degradation
animal
Reactive Oxygen Species
Animals
Repair
Epithelium

Keywords

  • Bleomycin
  • Interstitial lung fibrosis
  • Niacin
  • Taurine

ASJC Scopus subject areas

  • Environmental Science(all)
  • Environmental Chemistry
  • Public Health, Environmental and Occupational Health

Cite this

Amelioration of bleomycin-induced lung fibrosis in hamsters by dietary supplementation with taurine and niacin : Biochemical mechanisms. / Giri, S. N.; Blaisdell, R.; Rucker, R. B.; Wang, Q.; Hyde, D. M.

In: Environmental Health Perspectives, Vol. 102, No. SUPPL. 10, 1994, p. 137-147.

Research output: Contribution to journalArticle

Giri, S. N. ; Blaisdell, R. ; Rucker, R. B. ; Wang, Q. ; Hyde, D. M. / Amelioration of bleomycin-induced lung fibrosis in hamsters by dietary supplementation with taurine and niacin : Biochemical mechanisms. In: Environmental Health Perspectives. 1994 ; Vol. 102, No. SUPPL. 10. pp. 137-147.
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