Ameliorating effect of murine interferon gamma on bleomycin-induced lung collagen fibrosis in mice

Shri N. Giri, Dallas M. Hyde, Benedict J. Marafino

Research output: Contribution to journalArticle

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Abstract

Fibrotic lung diseases are characterized by accumulation of collagen in the lung (1). These diseases generally respond poorly to drug therapy (1). A variety of chemicals have been tested in different experimental models of lung fibrosis to ameliorate or prevent the development of fibrosis (2-4). In this regard, intratracheal instillation of bleomycin, an antineoplastic drug, is often employed to produce experimental models of lung fibrosis in hamsters (5,6), rats (7,8), and mice (9). Using the bleomycin model of lung fibrosis, we and others have tested the ability of various compounds to prevent lung fibrosis (5,7, 10,11). It is unfortunate that these compounds were not satisfactory, since they produced systemic toxicity and lacked specificity in inhibiting collagen biosynthesis. Regulation of collagen metabolism is not completely understood. However, it is generally believed that the immune system and inflammatory conditions affect the metabolic functions of the fibroblasts responsible for collagen synthesis and deposition (12). Recently Rosenbloom et al. (13) have demonstrated that interferon gamma had a potent inhibitory effect on collagen synthesis by cultured human diploid fibrolasts. The inhibitory effect was attributed to a reduction in the levels of collagen mRNA. In the present paper we report that the administration of recombinant murine interferon gamma (IFN-γ) caused a significant reduction in the accumulation of collagen in the lungs of bleomycin-treated mice.

Original languageEnglish (US)
Pages (from-to)194-197
Number of pages4
JournalBiochemical Medicine and Metabolic Biology
Volume36
Issue number2
DOIs
StatePublished - 1986

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Bleomycin
Interferon-gamma
Fibrosis
Collagen
Lung
Theoretical Models
Drug therapy
Pulmonary diseases
Immune system
Biosynthesis
Fibroblasts
Diploidy
Metabolism
Cricetinae
Antineoplastic Agents
Lung Diseases
Toxicity
Rats
Immune System
Drug Therapy

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Ameliorating effect of murine interferon gamma on bleomycin-induced lung collagen fibrosis in mice. / Giri, Shri N.; Hyde, Dallas M.; Marafino, Benedict J.

In: Biochemical Medicine and Metabolic Biology, Vol. 36, No. 2, 1986, p. 194-197.

Research output: Contribution to journalArticle

Giri, Shri N. ; Hyde, Dallas M. ; Marafino, Benedict J. / Ameliorating effect of murine interferon gamma on bleomycin-induced lung collagen fibrosis in mice. In: Biochemical Medicine and Metabolic Biology. 1986 ; Vol. 36, No. 2. pp. 194-197.
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