Amdoparvovirus Infection in Red Pandas (Ailurus fulgens)

Charles E. Alex, Steven V. Kubiski, Linlin Li, Mohammadreza Sadeghi, Raymund F. Wack, Megan A. McCarthy, Joseph B. Pesavento, Eric Delwart, Patricia Pesavento

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Aleutian mink disease virus is the type species in the genus Amdoparvovirus, and in mink and other Mustelidae can cause either subclinical disease or fatal chronic immune stimulation and immune complex disease. The authors describe a novel amdoparvovirus in the endangered red panda (Ailurus fulgens), discovered using viral metagenomics. The authors analyzed the prevalence, tissue distribution, and disease association by PCR, in situ hybridization, electron microscopy, and histology in a group of 6 red pandas from a single zoological collection. The study incorporates a fecal shedding survey and analysis of tissues from 4 necropsied animals over a 12-year span. The tentatively named red panda amdoparvovirus (RpAPV) was detected in the feces and/or tissues of all animals tested. At necropsy of 1 geriatric animal, infection was associated with pyogranulomatous peritonitis, pancreatitis, and myocarditis. Other animals had detectable low-level viral nucleic acid in lymph nodes and both oral and intestinal epithelium at the time of necropsy. Full-length genome sequences of RpAPV strains from 2 animals had 12% sequence divergence, demonstrating genetic diversity even among in-contact animals. RpAPV is a persistent infection in this cohort of red pandas, and has variable clinical expression.

Original languageEnglish (US)
JournalVeterinary Pathology
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

Ailuridae
Infection
infection
animals
Aleutian Mink Disease Virus
necropsy
Immune Complex Diseases
immune complex diseases
Mustelidae
Aleutian mink disease virus
Mink
Metagenomics
Myocarditis
myocarditis
Tissue Distribution
tissue analysis
Intestinal Mucosa
pancreatitis
Peritonitis
peritonitis

Keywords

  • Ailurus fulgens
  • amdoparvovirus
  • electron microscopy
  • endangered species
  • in situ hybridization
  • metagenomics
  • red panda

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Alex, C. E., Kubiski, S. V., Li, L., Sadeghi, M., Wack, R. F., McCarthy, M. A., ... Pesavento, P. (Accepted/In press). Amdoparvovirus Infection in Red Pandas (Ailurus fulgens). Veterinary Pathology. https://doi.org/10.1177/0300985818758470

Amdoparvovirus Infection in Red Pandas (Ailurus fulgens). / Alex, Charles E.; Kubiski, Steven V.; Li, Linlin; Sadeghi, Mohammadreza; Wack, Raymund F.; McCarthy, Megan A.; Pesavento, Joseph B.; Delwart, Eric; Pesavento, Patricia.

In: Veterinary Pathology, 01.01.2018.

Research output: Contribution to journalArticle

Alex, CE, Kubiski, SV, Li, L, Sadeghi, M, Wack, RF, McCarthy, MA, Pesavento, JB, Delwart, E & Pesavento, P 2018, 'Amdoparvovirus Infection in Red Pandas (Ailurus fulgens)', Veterinary Pathology. https://doi.org/10.1177/0300985818758470
Alex CE, Kubiski SV, Li L, Sadeghi M, Wack RF, McCarthy MA et al. Amdoparvovirus Infection in Red Pandas (Ailurus fulgens). Veterinary Pathology. 2018 Jan 1. https://doi.org/10.1177/0300985818758470
Alex, Charles E. ; Kubiski, Steven V. ; Li, Linlin ; Sadeghi, Mohammadreza ; Wack, Raymund F. ; McCarthy, Megan A. ; Pesavento, Joseph B. ; Delwart, Eric ; Pesavento, Patricia. / Amdoparvovirus Infection in Red Pandas (Ailurus fulgens). In: Veterinary Pathology. 2018.
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