Abstract
What is already known about this topic? Ingestion of Amanita phalloides is responsible for a majority of mushroom-related deaths worldwide. Amatoxins, the principal toxic alkaloids found in these fungi, cause cell injury by halting protein synthesis. A possible antidote licensed in most of Europe, intravenous silibinin, is undergoing evaluation by clinical trial in the United States. What is added by this report? In December 2016, fourteen cases of Amanita phalloides poisoning were identified by the California Poison Control System (CPCS) among persons who had consumed foraged wild mushrooms. In the past few years before this outbreak, CPCS only received reports of a few mushroom poisoning cases per year. All patients in this outbreak had gastrointestinal manifestations of intoxication leading to dehydration and hepatotoxicity. Three patients received liver transplants; all patients recovered, although one (a child) had permanent neurologic impairment. What are the implications for public health practice? Wild-picked mushrooms should be evaluated by a trained mycologist before ingestion. Inexperienced foragers should be strongly discouraged from eating any wild mushrooms. Health care providers should be aware of the potential for toxicity after wild mushroom ingestion, that gastrointestinal symptoms mimicking viral gastroenteritis can occur after ingestion and slowly progress to potentially fatal hepatotoxicity, and should contact the local poison center for reporting and assistance with management of these patients.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 549-553 |
| Number of pages | 5 |
| Journal | Morbidity and Mortality Weekly Report |
| Volume | 66 |
| Issue number | 21 |
| DOIs | |
| State | Published - Jun 2 2017 |
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ASJC Scopus subject areas
- Epidemiology
- Health(social science)
- Health, Toxicology and Mutagenesis
- Health Information Management
Cite this
Amanita phalloides mushroom poisonings - Northern California, December 2016. / Vo, Kathy T.; Montgomery, Martha E.; Todd Mitchell, S.; Scheerlinck, Pieter H.; Colby, Daniel; Meier, Kathryn H.; Kim-Katz, Susan; Anderson, Ilene B.; Offerman, Steven R.; Olson, Kent R.; Smollin, Craig G.
In: Morbidity and Mortality Weekly Report, Vol. 66, No. 21, 02.06.2017, p. 549-553.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Amanita phalloides mushroom poisonings - Northern California, December 2016
AU - Vo, Kathy T.
AU - Montgomery, Martha E.
AU - Todd Mitchell, S.
AU - Scheerlinck, Pieter H.
AU - Colby, Daniel
AU - Meier, Kathryn H.
AU - Kim-Katz, Susan
AU - Anderson, Ilene B.
AU - Offerman, Steven R.
AU - Olson, Kent R.
AU - Smollin, Craig G.
PY - 2017/6/2
Y1 - 2017/6/2
N2 - What is already known about this topic? Ingestion of Amanita phalloides is responsible for a majority of mushroom-related deaths worldwide. Amatoxins, the principal toxic alkaloids found in these fungi, cause cell injury by halting protein synthesis. A possible antidote licensed in most of Europe, intravenous silibinin, is undergoing evaluation by clinical trial in the United States. What is added by this report? In December 2016, fourteen cases of Amanita phalloides poisoning were identified by the California Poison Control System (CPCS) among persons who had consumed foraged wild mushrooms. In the past few years before this outbreak, CPCS only received reports of a few mushroom poisoning cases per year. All patients in this outbreak had gastrointestinal manifestations of intoxication leading to dehydration and hepatotoxicity. Three patients received liver transplants; all patients recovered, although one (a child) had permanent neurologic impairment. What are the implications for public health practice? Wild-picked mushrooms should be evaluated by a trained mycologist before ingestion. Inexperienced foragers should be strongly discouraged from eating any wild mushrooms. Health care providers should be aware of the potential for toxicity after wild mushroom ingestion, that gastrointestinal symptoms mimicking viral gastroenteritis can occur after ingestion and slowly progress to potentially fatal hepatotoxicity, and should contact the local poison center for reporting and assistance with management of these patients.
AB - What is already known about this topic? Ingestion of Amanita phalloides is responsible for a majority of mushroom-related deaths worldwide. Amatoxins, the principal toxic alkaloids found in these fungi, cause cell injury by halting protein synthesis. A possible antidote licensed in most of Europe, intravenous silibinin, is undergoing evaluation by clinical trial in the United States. What is added by this report? In December 2016, fourteen cases of Amanita phalloides poisoning were identified by the California Poison Control System (CPCS) among persons who had consumed foraged wild mushrooms. In the past few years before this outbreak, CPCS only received reports of a few mushroom poisoning cases per year. All patients in this outbreak had gastrointestinal manifestations of intoxication leading to dehydration and hepatotoxicity. Three patients received liver transplants; all patients recovered, although one (a child) had permanent neurologic impairment. What are the implications for public health practice? Wild-picked mushrooms should be evaluated by a trained mycologist before ingestion. Inexperienced foragers should be strongly discouraged from eating any wild mushrooms. Health care providers should be aware of the potential for toxicity after wild mushroom ingestion, that gastrointestinal symptoms mimicking viral gastroenteritis can occur after ingestion and slowly progress to potentially fatal hepatotoxicity, and should contact the local poison center for reporting and assistance with management of these patients.
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UR - http://www.scopus.com/inward/citedby.url?scp=85020183204&partnerID=8YFLogxK
U2 - 10.15585/mmwr.mm6621a1
DO - 10.15585/mmwr.mm6621a1
M3 - Article
C2 - 28570504
AN - SCOPUS:85020183204
VL - 66
SP - 549
EP - 553
JO - Morbidity and Mortality Weekly Report
JF - Morbidity and Mortality Weekly Report
SN - 0149-2195
IS - 21
ER -