Alzheimer's disease

Ameliorating symptoms

John M Olichney, R. J. Ellis, L. J. Thal

Research output: Contribution to journalArticle

Abstract

Today, treatment can ameliorate many of the cognitive and behavioral symptoms of Alzheimer's disease (AD). Managing outpatient behavioral problems involves cooperation of responsible caretakers, targeting specific unwanted behaviors, and considering intercurrent illness, pain, and sensory impairment. In implementing therapies, physicians must consider the side effects of drugs that can be given to older patients with frequent comorbidities and a prominent deficiency of cholinergic neurotransmitter systems. A new focus of research involves delaying or preventing disease onset. Through a better understanding of inflammatory mechanisms, apolipoprotein E, amyloid deposition, and trophic factors, future therapies may lessen the impact of AD on the aging.

Original languageEnglish (US)
Pages (from-to)38-55
Number of pages18
JournalIM - Internal Medicine
Volume16
Issue number2
StatePublished - 1995

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Alzheimer Disease
Behavioral Symptoms
Neurobehavioral Manifestations
Apolipoproteins E
Drug-Related Side Effects and Adverse Reactions
Amyloid
Cholinergic Agents
Neurotransmitter Agents
Comorbidity
Outpatients
Therapeutics
Physicians
Pain
Research
Problem Behavior

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Olichney, J. M., Ellis, R. J., & Thal, L. J. (1995). Alzheimer's disease: Ameliorating symptoms. IM - Internal Medicine, 16(2), 38-55.

Alzheimer's disease : Ameliorating symptoms. / Olichney, John M; Ellis, R. J.; Thal, L. J.

In: IM - Internal Medicine, Vol. 16, No. 2, 1995, p. 38-55.

Research output: Contribution to journalArticle

Olichney, JM, Ellis, RJ & Thal, LJ 1995, 'Alzheimer's disease: Ameliorating symptoms', IM - Internal Medicine, vol. 16, no. 2, pp. 38-55.
Olichney, John M ; Ellis, R. J. ; Thal, L. J. / Alzheimer's disease : Ameliorating symptoms. In: IM - Internal Medicine. 1995 ; Vol. 16, No. 2. pp. 38-55.
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