Abstract
Today, treatment can ameliorate many of the cognitive and behavioral symptoms of Alzheimer's disease (AD). Managing outpatient behavioral problems involves cooperation of responsible caretakers, targeting specific unwanted behaviors, and considering intercurrent illness, pain, and sensory impairment. In implementing therapies, physicians must consider the side effects of drugs that can be given to older patients with frequent comorbidities and a prominent deficiency of cholinergic neurotransmitter systems. A new focus of research involves delaying or preventing disease onset. Through a better understanding of inflammatory mechanisms, apolipoprotein E, amyloid deposition, and trophic factors, future therapies may lessen the impact of AD on the aging.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 38-55 |
| Number of pages | 18 |
| Journal | IM - Internal Medicine |
| Volume | 16 |
| Issue number | 2 |
| State | Published - 1995 |
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ASJC Scopus subject areas
- Internal Medicine
Cite this
Alzheimer's disease : Ameliorating symptoms. / Olichney, John M; Ellis, R. J.; Thal, L. J.
In: IM - Internal Medicine, Vol. 16, No. 2, 1995, p. 38-55.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Alzheimer's disease
T2 - Ameliorating symptoms
AU - Olichney, John M
AU - Ellis, R. J.
AU - Thal, L. J.
PY - 1995
Y1 - 1995
N2 - Today, treatment can ameliorate many of the cognitive and behavioral symptoms of Alzheimer's disease (AD). Managing outpatient behavioral problems involves cooperation of responsible caretakers, targeting specific unwanted behaviors, and considering intercurrent illness, pain, and sensory impairment. In implementing therapies, physicians must consider the side effects of drugs that can be given to older patients with frequent comorbidities and a prominent deficiency of cholinergic neurotransmitter systems. A new focus of research involves delaying or preventing disease onset. Through a better understanding of inflammatory mechanisms, apolipoprotein E, amyloid deposition, and trophic factors, future therapies may lessen the impact of AD on the aging.
AB - Today, treatment can ameliorate many of the cognitive and behavioral symptoms of Alzheimer's disease (AD). Managing outpatient behavioral problems involves cooperation of responsible caretakers, targeting specific unwanted behaviors, and considering intercurrent illness, pain, and sensory impairment. In implementing therapies, physicians must consider the side effects of drugs that can be given to older patients with frequent comorbidities and a prominent deficiency of cholinergic neurotransmitter systems. A new focus of research involves delaying or preventing disease onset. Through a better understanding of inflammatory mechanisms, apolipoprotein E, amyloid deposition, and trophic factors, future therapies may lessen the impact of AD on the aging.
UR - http://www.scopus.com/inward/record.url?scp=0028800825&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028800825&partnerID=8YFLogxK
M3 - Article
VL - 16
SP - 38
EP - 55
JO - IM - Internal Medicine
JF - IM - Internal Medicine
SN - 1056-9286
IS - 2
ER -