Alveolar volume and sequential filling impact the estimation of DLCO and DLNO

N. M. Tsoukias, D. Dabdub, A. F. Wilson, Steven George

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

This paper presents the development, testing, and application to experimental data of a new model to: 1) estimate the degree of sequential filling during inhalation, and 2) the dependence of the diffusing capacity (DL) on alveolar volume (VA). The model assesses sequential filling through a single parameter, k, where k = 0 represents complete alveolar mixing, and k = 1 represents no alveolar mixing (sequential filling). A linear (a+bVA) and an exponential (αVA β) dependence of DL are used to describe the volume dependence of DL for carbon monoxide (CO) and nitric oxide (NO), respectively. Application of the model to experimental data from 7 normal humans predicts k = 0.51 (0.35), b = 0.69 (0.79), and β = 0.65 (0.19) (mean (SD)). We conclude: 1) DL depends on lung volume (strongly for NO, weakly for CO), and 2) the effect of sequential filling must be considered when estimating DL.

Original languageEnglish (US)
Title of host publicationAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
PublisherIEEE
Number of pages1
Volume1
ISBN (Print)0780356756
StatePublished - Dec 1 1999
EventProceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS) - Atlanta, GA, USA
Duration: Oct 13 1999Oct 16 1999

Other

OtherProceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS)
CityAtlanta, GA, USA
Period10/13/9910/16/99

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

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