Aluminum enhances melanin-induced lipid peroxidation

Leonardo Meglio, Patricia I. Oteiza

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


The present study was conducted to characterize the possible interaction of Al3+ and Fe2+ with synthetic melanin in the potentiation of lipid peroxidation in liposomes and rat caudate-putamen homogenates. Al3+ stimulated melanin-initiated lipid peroxidation as measured by the production of 2-thiobarbituric acid-reactive substances (TBARS) and conjugated dienes. The effect of Al3+ was dependent on melanin (10-100 μg/ml) and Al3+ (2.5-250 μM) concentrations and no synergism between Fe2+ and Al3+ was observed. The prooxidant effect of Al3+ was partially inhibited by superoxide dismutase indicating the involvement of Q2-, Ga3+ and Be2+ which can increase NADH oxidation in the presence of Q2-, also were shown to stimulate melanin-initiated TBARS production. Based on the effect of Al3+ and other non redox metals, we suggest that Al3+ does not act through either the induction of melanin free radicals, or the induction of changes in membrane physical properties. Results show that Al3+ enhances melanin-initiated lipid peroxidation in part through an interaction with O2- generated from the autoxidation of melanin. We speculate that Al3+ contributes to neuromelanin-mediated oxidative damage in dopaminergic neurons and subsequent neuronal degeneration and death in Parkinson's disease.

Original languageEnglish (US)
Pages (from-to)1001-1008
Number of pages8
JournalNeurochemical Research
Issue number8
StatePublished - 1999
Externally publishedYes


  • Aluminum
  • Free radicals
  • Lipid peroxidation
  • Melanin
  • Neuromelanin
  • Parkinson

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry


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