Altered time course of amygdala activation during speech anticipation in social anxiety disorder

Carolyn D. Davies, Katherine Young, Jared B. Torre, Lisa J. Burklund, Philip R Goldin, Lily A. Brown, Andrea N. Niles, Matthew D. Lieberman, Michelle G. Craske

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Background Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n=58; HC n=16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90 s control anticipation task and 90 s speech anticipation task. Repeated measures multi-level modeling analyses were used to examine group differences in time course activity during speech vs. control anticipation for regions of interest, including bilateral amygdala, insula, ventral striatum, and dorsal anterior cingulate cortex. Results The time course of amygdala activity was more prolonged and less variable throughout speech anticipation in SAD participants compared to HCs, whereas the overall magnitude of amygdala response did not differ between groups. Magnitude and time course of activity was largely similar between groups across other regions of interest. Limitations Analyses were restricted to regions of interest and task order was the same across participants due to the nature of deception instructions. Conclusions Sustained amygdala time course during anticipation may uniquely reflect heightened detection of threat or deficits in emotion regulation in socially anxious individuals. Findings highlight the importance of examining temporal dynamics of amygdala responding.

Original languageEnglish (US)
Pages (from-to)23-29
Number of pages7
JournalJournal of Affective Disorders
Volume209
DOIs
StatePublished - Feb 1 2017

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Keywords

  • Amygdala
  • Anticipation
  • fMRI
  • Public speaking
  • Social anxiety disorder

ASJC Scopus subject areas

  • Clinical Psychology
  • Psychiatry and Mental health

Cite this

Davies, C. D., Young, K., Torre, J. B., Burklund, L. J., Goldin, P. R., Brown, L. A., Niles, A. N., Lieberman, M. D., & Craske, M. G. (2017). Altered time course of amygdala activation during speech anticipation in social anxiety disorder. Journal of Affective Disorders, 209, 23-29. https://doi.org/10.1016/j.jad.2016.11.014