Altered soluble epoxide hydrolase-derived oxylipins in patients with seasonal major depression: An exploratory study

Marie Hennebelle, Yurika Otoki, Jun Yang, Bruce D. Hammock, Anthony J. Levitt, Ameer Y. Taha, Walter Swardfager

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Many cytochrome p450-derived lipids promote resolution of inflammation, in contrast to their soluble epoxide hydrolase(sEH)-derived oxylipin breakdown products. Here we compare plasma oxylipins and precursor fatty acids between seasons in participants with major depressive disorder with seasonal pattern (MDD-s). Euthymic participants with a history of MDD-s recruited in summer-fall were followed-up in winter. At both visits, a structured clinical interview (DSM-5 criteria) and the Beck Depression Inventory II (BDI-II) were administered. Unesterified and total oxylipin pools were assayed by liquid chromatography tandem mass-spectrometry (LC-MS/MS). Precursor fatty acids were measured by gas chromatography. In nine unmedicated participants euthymic at baseline who met depression criteria in winter, BDI-II scores increased from 4.9±4.4 to 19.9±7.7. Four sEH-derived oxylipins increased in winter compared to summer-fall with moderate to large effect sizes. An auto-oxidation product (unesterified epoxyketooctadecadienoic acid) and lipoxygenase-derived 13-hydroxyoctadecadienoic acid also increased in winter. The cytochrome p450-derived 20-COOH-leukotriene B4 (unesterified) and total 14(15)-epoxyeicosatetraenoic acid, and the sEH-derived 14,15-dihydroxyeicostrienoic acid (unesterified), decreased in winter. We conclude that winter depression was associated with changes in cytochrome p450- and sEH-derived oxylipins, suggesting that seasonal shifts in omega-6 and omega-3 fatty acid metabolism mediated by sEH may underlie inflammatory states in symptomatic MDD-s.

Original languageEnglish (US)
Pages (from-to)94-101
Number of pages8
JournalPsychiatry Research
Volume252
DOIs
StatePublished - Jun 1 2017

Fingerprint

Oxylipins
Epoxide Hydrolases
Depression
Major Depressive Disorder
Cytochrome P-450 Enzyme System
Acids
Fatty Acids
Equipment and Supplies
Leukotriene B4
Lipoxygenase
Omega-3 Fatty Acids
Tandem Mass Spectrometry
Liquid Chromatography
Gas Chromatography
Interviews
Inflammation
Lipids

Keywords

  • Cytochrome p450
  • Depression
  • Fatty acids
  • Lipidomics
  • Omega-3
  • Omega-6
  • Oxylipins
  • Seasonal major depression
  • Soluble epoxide hydrolase

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Hennebelle, M., Otoki, Y., Yang, J., Hammock, B. D., Levitt, A. J., Taha, A. Y., & Swardfager, W. (2017). Altered soluble epoxide hydrolase-derived oxylipins in patients with seasonal major depression: An exploratory study. Psychiatry Research, 252, 94-101. https://doi.org/10.1016/j.psychres.2017.02.056

Altered soluble epoxide hydrolase-derived oxylipins in patients with seasonal major depression : An exploratory study. / Hennebelle, Marie; Otoki, Yurika; Yang, Jun; Hammock, Bruce D.; Levitt, Anthony J.; Taha, Ameer Y.; Swardfager, Walter.

In: Psychiatry Research, Vol. 252, 01.06.2017, p. 94-101.

Research output: Contribution to journalArticle

Hennebelle, Marie ; Otoki, Yurika ; Yang, Jun ; Hammock, Bruce D. ; Levitt, Anthony J. ; Taha, Ameer Y. ; Swardfager, Walter. / Altered soluble epoxide hydrolase-derived oxylipins in patients with seasonal major depression : An exploratory study. In: Psychiatry Research. 2017 ; Vol. 252. pp. 94-101.
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