Abstract
Many cytochrome p450-derived lipids promote resolution of inflammation, in contrast to their soluble epoxide hydrolase(sEH)-derived oxylipin breakdown products. Here we compare plasma oxylipins and precursor fatty acids between seasons in participants with major depressive disorder with seasonal pattern (MDD-s). Euthymic participants with a history of MDD-s recruited in summer-fall were followed-up in winter. At both visits, a structured clinical interview (DSM-5 criteria) and the Beck Depression Inventory II (BDI-II) were administered. Unesterified and total oxylipin pools were assayed by liquid chromatography tandem mass-spectrometry (LC-MS/MS). Precursor fatty acids were measured by gas chromatography. In nine unmedicated participants euthymic at baseline who met depression criteria in winter, BDI-II scores increased from 4.9±4.4 to 19.9±7.7. Four sEH-derived oxylipins increased in winter compared to summer-fall with moderate to large effect sizes. An auto-oxidation product (unesterified epoxyketooctadecadienoic acid) and lipoxygenase-derived 13-hydroxyoctadecadienoic acid also increased in winter. The cytochrome p450-derived 20-COOH-leukotriene B4 (unesterified) and total 14(15)-epoxyeicosatetraenoic acid, and the sEH-derived 14,15-dihydroxyeicostrienoic acid (unesterified), decreased in winter. We conclude that winter depression was associated with changes in cytochrome p450- and sEH-derived oxylipins, suggesting that seasonal shifts in omega-6 and omega-3 fatty acid metabolism mediated by sEH may underlie inflammatory states in symptomatic MDD-s.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 94-101 |
| Number of pages | 8 |
| Journal | Psychiatry Research |
| Volume | 252 |
| DOIs | |
| State | Published - Jun 1 2017 |
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Keywords
- Cytochrome p450
- Depression
- Fatty acids
- Lipidomics
- Omega-3
- Omega-6
- Oxylipins
- Seasonal major depression
- Soluble epoxide hydrolase
ASJC Scopus subject areas
- Psychiatry and Mental health
- Biological Psychiatry
Cite this
Altered soluble epoxide hydrolase-derived oxylipins in patients with seasonal major depression : An exploratory study. / Hennebelle, Marie; Otoki, Yurika; Yang, Jun; Hammock, Bruce D.; Levitt, Anthony J.; Taha, Ameer Y.; Swardfager, Walter.
In: Psychiatry Research, Vol. 252, 01.06.2017, p. 94-101.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Altered soluble epoxide hydrolase-derived oxylipins in patients with seasonal major depression
T2 - An exploratory study
AU - Hennebelle, Marie
AU - Otoki, Yurika
AU - Yang, Jun
AU - Hammock, Bruce D.
AU - Levitt, Anthony J.
AU - Taha, Ameer Y.
AU - Swardfager, Walter
PY - 2017/6/1
Y1 - 2017/6/1
N2 - Many cytochrome p450-derived lipids promote resolution of inflammation, in contrast to their soluble epoxide hydrolase(sEH)-derived oxylipin breakdown products. Here we compare plasma oxylipins and precursor fatty acids between seasons in participants with major depressive disorder with seasonal pattern (MDD-s). Euthymic participants with a history of MDD-s recruited in summer-fall were followed-up in winter. At both visits, a structured clinical interview (DSM-5 criteria) and the Beck Depression Inventory II (BDI-II) were administered. Unesterified and total oxylipin pools were assayed by liquid chromatography tandem mass-spectrometry (LC-MS/MS). Precursor fatty acids were measured by gas chromatography. In nine unmedicated participants euthymic at baseline who met depression criteria in winter, BDI-II scores increased from 4.9±4.4 to 19.9±7.7. Four sEH-derived oxylipins increased in winter compared to summer-fall with moderate to large effect sizes. An auto-oxidation product (unesterified epoxyketooctadecadienoic acid) and lipoxygenase-derived 13-hydroxyoctadecadienoic acid also increased in winter. The cytochrome p450-derived 20-COOH-leukotriene B4 (unesterified) and total 14(15)-epoxyeicosatetraenoic acid, and the sEH-derived 14,15-dihydroxyeicostrienoic acid (unesterified), decreased in winter. We conclude that winter depression was associated with changes in cytochrome p450- and sEH-derived oxylipins, suggesting that seasonal shifts in omega-6 and omega-3 fatty acid metabolism mediated by sEH may underlie inflammatory states in symptomatic MDD-s.
AB - Many cytochrome p450-derived lipids promote resolution of inflammation, in contrast to their soluble epoxide hydrolase(sEH)-derived oxylipin breakdown products. Here we compare plasma oxylipins and precursor fatty acids between seasons in participants with major depressive disorder with seasonal pattern (MDD-s). Euthymic participants with a history of MDD-s recruited in summer-fall were followed-up in winter. At both visits, a structured clinical interview (DSM-5 criteria) and the Beck Depression Inventory II (BDI-II) were administered. Unesterified and total oxylipin pools were assayed by liquid chromatography tandem mass-spectrometry (LC-MS/MS). Precursor fatty acids were measured by gas chromatography. In nine unmedicated participants euthymic at baseline who met depression criteria in winter, BDI-II scores increased from 4.9±4.4 to 19.9±7.7. Four sEH-derived oxylipins increased in winter compared to summer-fall with moderate to large effect sizes. An auto-oxidation product (unesterified epoxyketooctadecadienoic acid) and lipoxygenase-derived 13-hydroxyoctadecadienoic acid also increased in winter. The cytochrome p450-derived 20-COOH-leukotriene B4 (unesterified) and total 14(15)-epoxyeicosatetraenoic acid, and the sEH-derived 14,15-dihydroxyeicostrienoic acid (unesterified), decreased in winter. We conclude that winter depression was associated with changes in cytochrome p450- and sEH-derived oxylipins, suggesting that seasonal shifts in omega-6 and omega-3 fatty acid metabolism mediated by sEH may underlie inflammatory states in symptomatic MDD-s.
KW - Cytochrome p450
KW - Depression
KW - Fatty acids
KW - Lipidomics
KW - Omega-3
KW - Omega-6
KW - Oxylipins
KW - Seasonal major depression
KW - Soluble epoxide hydrolase
UR - http://www.scopus.com/inward/record.url?scp=85014103334&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85014103334&partnerID=8YFLogxK
U2 - 10.1016/j.psychres.2017.02.056
DO - 10.1016/j.psychres.2017.02.056
M3 - Article
AN - SCOPUS:85014103334
VL - 252
SP - 94
EP - 101
JO - Psychiatry Research
JF - Psychiatry Research
SN - 0165-1781
ER -