Altered reward processing in women recovered from anorexia nervosa

Angela Wagner, Howard Aizenstein, Vijay K. Venkatraman, Julie Fudge, J. Christopher May, Laura Mazurkewicz, Guido K. Frank, Ursula F. Bailer, Lorie Fischer, Van Nguyen, Cameron Carter, Karen Putnam, Walter H. Kaye

Research output: Contribution to journalArticle

246 Citations (Scopus)

Abstract

Objective: Individuals with anorexia nervosa are known to be ascetic and able to sustain self-denial of food as well as most comforts and pleasures in life. Building on previous findings of altered striatal dopamine binding in anorexia nervosa, the authors sought to assess the response of the anterior ventral striatum to reward and loss in this disorder. Method: Striatal responses to a simple monetary reward task were investigated using event-related functional magnetic resonance imaging. To avoid the confounding effects of malnutrition, the authors compared 13 healthy comparison women and 13 women who had recovered from restricting-type anorexia nervosa and had 1 year of normal weight and regular menstrual cycles, without binge eating or purging. Results: Recovered women showed greater hemodynamic activation in the caudate than comparison women. Only the recovered women showed a significant positive relationship between trait anxiety and the percentage change in hemodynamic signal in the caudate during either wins or losses. In contrast, in the anterior ventral striatum, comparison women distinguished positive and negative feedback, whereas recovered women had similar responses to both conditions. Conclusions: Individuals who have recovered from anorexia nervosa may have difficulties in differentiating positive and negative feedback. The exaggerated activation of the caudate, a region involved in linking action to outcome, may constitute an attempt at "strategic" (as opposed to hedonic) means of responding to reward stimuli. The authors hypothesize that individuals with anorexia nervosa have an imbalance in information processing, with impaired ability to identify the emotional significance of a stimulus but increased traffic in neurocircuits concerned with planning and consequences.

Original languageEnglish (US)
Pages (from-to)1842-1849
Number of pages8
JournalAmerican Journal of Psychiatry
Volume164
Issue number12
DOIs
StatePublished - Dec 2007

Fingerprint

Anorexia Nervosa
Reward
Corpus Striatum
Pleasure
Hemodynamics
Bulimia
Aptitude
Menstrual Cycle
Automatic Data Processing
Malnutrition
Dopamine
Anxiety
Magnetic Resonance Imaging
Weights and Measures
Food

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Wagner, A., Aizenstein, H., Venkatraman, V. K., Fudge, J., May, J. C., Mazurkewicz, L., ... Kaye, W. H. (2007). Altered reward processing in women recovered from anorexia nervosa. American Journal of Psychiatry, 164(12), 1842-1849. https://doi.org/10.1176/appi.ajp.2007.07040575

Altered reward processing in women recovered from anorexia nervosa. / Wagner, Angela; Aizenstein, Howard; Venkatraman, Vijay K.; Fudge, Julie; May, J. Christopher; Mazurkewicz, Laura; Frank, Guido K.; Bailer, Ursula F.; Fischer, Lorie; Nguyen, Van; Carter, Cameron; Putnam, Karen; Kaye, Walter H.

In: American Journal of Psychiatry, Vol. 164, No. 12, 12.2007, p. 1842-1849.

Research output: Contribution to journalArticle

Wagner, A, Aizenstein, H, Venkatraman, VK, Fudge, J, May, JC, Mazurkewicz, L, Frank, GK, Bailer, UF, Fischer, L, Nguyen, V, Carter, C, Putnam, K & Kaye, WH 2007, 'Altered reward processing in women recovered from anorexia nervosa', American Journal of Psychiatry, vol. 164, no. 12, pp. 1842-1849. https://doi.org/10.1176/appi.ajp.2007.07040575
Wagner A, Aizenstein H, Venkatraman VK, Fudge J, May JC, Mazurkewicz L et al. Altered reward processing in women recovered from anorexia nervosa. American Journal of Psychiatry. 2007 Dec;164(12):1842-1849. https://doi.org/10.1176/appi.ajp.2007.07040575
Wagner, Angela ; Aizenstein, Howard ; Venkatraman, Vijay K. ; Fudge, Julie ; May, J. Christopher ; Mazurkewicz, Laura ; Frank, Guido K. ; Bailer, Ursula F. ; Fischer, Lorie ; Nguyen, Van ; Carter, Cameron ; Putnam, Karen ; Kaye, Walter H. / Altered reward processing in women recovered from anorexia nervosa. In: American Journal of Psychiatry. 2007 ; Vol. 164, No. 12. pp. 1842-1849.
@article{90b6d29b83db4486b1657429fcdd32fa,
title = "Altered reward processing in women recovered from anorexia nervosa",
abstract = "Objective: Individuals with anorexia nervosa are known to be ascetic and able to sustain self-denial of food as well as most comforts and pleasures in life. Building on previous findings of altered striatal dopamine binding in anorexia nervosa, the authors sought to assess the response of the anterior ventral striatum to reward and loss in this disorder. Method: Striatal responses to a simple monetary reward task were investigated using event-related functional magnetic resonance imaging. To avoid the confounding effects of malnutrition, the authors compared 13 healthy comparison women and 13 women who had recovered from restricting-type anorexia nervosa and had 1 year of normal weight and regular menstrual cycles, without binge eating or purging. Results: Recovered women showed greater hemodynamic activation in the caudate than comparison women. Only the recovered women showed a significant positive relationship between trait anxiety and the percentage change in hemodynamic signal in the caudate during either wins or losses. In contrast, in the anterior ventral striatum, comparison women distinguished positive and negative feedback, whereas recovered women had similar responses to both conditions. Conclusions: Individuals who have recovered from anorexia nervosa may have difficulties in differentiating positive and negative feedback. The exaggerated activation of the caudate, a region involved in linking action to outcome, may constitute an attempt at {"}strategic{"} (as opposed to hedonic) means of responding to reward stimuli. The authors hypothesize that individuals with anorexia nervosa have an imbalance in information processing, with impaired ability to identify the emotional significance of a stimulus but increased traffic in neurocircuits concerned with planning and consequences.",
author = "Angela Wagner and Howard Aizenstein and Venkatraman, {Vijay K.} and Julie Fudge and May, {J. Christopher} and Laura Mazurkewicz and Frank, {Guido K.} and Bailer, {Ursula F.} and Lorie Fischer and Van Nguyen and Cameron Carter and Karen Putnam and Kaye, {Walter H.}",
year = "2007",
month = "12",
doi = "10.1176/appi.ajp.2007.07040575",
language = "English (US)",
volume = "164",
pages = "1842--1849",
journal = "American Journal of Psychiatry",
issn = "0002-953X",
publisher = "American Psychiatric Association",
number = "12",

}

TY - JOUR

T1 - Altered reward processing in women recovered from anorexia nervosa

AU - Wagner, Angela

AU - Aizenstein, Howard

AU - Venkatraman, Vijay K.

AU - Fudge, Julie

AU - May, J. Christopher

AU - Mazurkewicz, Laura

AU - Frank, Guido K.

AU - Bailer, Ursula F.

AU - Fischer, Lorie

AU - Nguyen, Van

AU - Carter, Cameron

AU - Putnam, Karen

AU - Kaye, Walter H.

PY - 2007/12

Y1 - 2007/12

N2 - Objective: Individuals with anorexia nervosa are known to be ascetic and able to sustain self-denial of food as well as most comforts and pleasures in life. Building on previous findings of altered striatal dopamine binding in anorexia nervosa, the authors sought to assess the response of the anterior ventral striatum to reward and loss in this disorder. Method: Striatal responses to a simple monetary reward task were investigated using event-related functional magnetic resonance imaging. To avoid the confounding effects of malnutrition, the authors compared 13 healthy comparison women and 13 women who had recovered from restricting-type anorexia nervosa and had 1 year of normal weight and regular menstrual cycles, without binge eating or purging. Results: Recovered women showed greater hemodynamic activation in the caudate than comparison women. Only the recovered women showed a significant positive relationship between trait anxiety and the percentage change in hemodynamic signal in the caudate during either wins or losses. In contrast, in the anterior ventral striatum, comparison women distinguished positive and negative feedback, whereas recovered women had similar responses to both conditions. Conclusions: Individuals who have recovered from anorexia nervosa may have difficulties in differentiating positive and negative feedback. The exaggerated activation of the caudate, a region involved in linking action to outcome, may constitute an attempt at "strategic" (as opposed to hedonic) means of responding to reward stimuli. The authors hypothesize that individuals with anorexia nervosa have an imbalance in information processing, with impaired ability to identify the emotional significance of a stimulus but increased traffic in neurocircuits concerned with planning and consequences.

AB - Objective: Individuals with anorexia nervosa are known to be ascetic and able to sustain self-denial of food as well as most comforts and pleasures in life. Building on previous findings of altered striatal dopamine binding in anorexia nervosa, the authors sought to assess the response of the anterior ventral striatum to reward and loss in this disorder. Method: Striatal responses to a simple monetary reward task were investigated using event-related functional magnetic resonance imaging. To avoid the confounding effects of malnutrition, the authors compared 13 healthy comparison women and 13 women who had recovered from restricting-type anorexia nervosa and had 1 year of normal weight and regular menstrual cycles, without binge eating or purging. Results: Recovered women showed greater hemodynamic activation in the caudate than comparison women. Only the recovered women showed a significant positive relationship between trait anxiety and the percentage change in hemodynamic signal in the caudate during either wins or losses. In contrast, in the anterior ventral striatum, comparison women distinguished positive and negative feedback, whereas recovered women had similar responses to both conditions. Conclusions: Individuals who have recovered from anorexia nervosa may have difficulties in differentiating positive and negative feedback. The exaggerated activation of the caudate, a region involved in linking action to outcome, may constitute an attempt at "strategic" (as opposed to hedonic) means of responding to reward stimuli. The authors hypothesize that individuals with anorexia nervosa have an imbalance in information processing, with impaired ability to identify the emotional significance of a stimulus but increased traffic in neurocircuits concerned with planning and consequences.

UR - http://www.scopus.com/inward/record.url?scp=38449120995&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=38449120995&partnerID=8YFLogxK

U2 - 10.1176/appi.ajp.2007.07040575

DO - 10.1176/appi.ajp.2007.07040575

M3 - Article

C2 - 18056239

AN - SCOPUS:38449120995

VL - 164

SP - 1842

EP - 1849

JO - American Journal of Psychiatry

JF - American Journal of Psychiatry

SN - 0002-953X

IS - 12

ER -