Altered postural reflexes in Parkinson's disease: A reverse hypothesis

B. R. Bloem, J. G. Van Dijk, D. J. Beckley, R. A C Roos, M. P. Remler, G. W. Bruyn

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

In subjects standing on a movable platform, sudden dorsiflexion of the ankle joint elicits a set of reflexes in leg muscles. These responses include a short latency (SL) and medium latency (ML) stretch reflex in the gastrocnemius muscle and a distal to proximal innervation sequence of long latency (LL) reflexes in the shortened tibialis anterior and vastus lateralis muscles. Because of their role in maintaining upright stance these responses have been termed postural reflexes. In patients with Parkinson's disease (PD), the following abnormalities have been described: 1) enhanced ML-amplitudes; 2) a reversed LL innervation sequence; and 3) delayed onset latencies. These abnormalities are thought to be due to defective motor programming and disturbed control of spinal and supraspinal reflex centers by basal ganglia circuits. The altered reflexes have been held responsible for some of the clinical features of PD, including balance impairment and rigidity. In this paper, we argue the reverse hypothesis that postural reflexes are essentially normal in PD, and that the observed alterations are at least in part consequence rather than cause of balance impairment, the stooped parkinsonian posture and rigidity of PD patients.

Original languageEnglish (US)
Pages (from-to)243-247
Number of pages5
JournalMedical Hypotheses
Volume39
Issue number3
DOIs
StatePublished - 1992
Externally publishedYes

ASJC Scopus subject areas

  • Developmental Biology
  • Medicine(all)
  • Drug Discovery

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    Bloem, B. R., Van Dijk, J. G., Beckley, D. J., Roos, R. A. C., Remler, M. P., & Bruyn, G. W. (1992). Altered postural reflexes in Parkinson's disease: A reverse hypothesis. Medical Hypotheses, 39(3), 243-247. https://doi.org/10.1016/0306-9877(92)90116-T