Altered NaCl concentration of airway surface liquid in cystic fibrosis

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

A novel isotopic technique suggests that the [Na] and [C1] of airway surface liquid are both normally ∼50 mM. In cystic fibrosis, lack of the functional cystic fibrosis transmembrane conductance regulator (CFTR) causes failure of transcellular C1 absorption, resulting in an elevation of [Na] and [C1] of airway surface liquid to ∼100 mM.

Original languageEnglish (US)
JournalPflugers Archiv European Journal of Physiology
Volume443
Issue numberSUPPL. 1
DOIs
StatePublished - 2001

Fingerprint

Cystic Fibrosis Transmembrane Conductance Regulator
Cystic Fibrosis
Liquids

Keywords

  • Active Na absorption
  • Airway surface liquid
  • Cystic fibrosis

ASJC Scopus subject areas

  • Physiology

Cite this

Altered NaCl concentration of airway surface liquid in cystic fibrosis. / Widdicombe, Jonathan.

In: Pflugers Archiv European Journal of Physiology, Vol. 443, No. SUPPL. 1, 2001.

Research output: Contribution to journalArticle

@article{915a41de95354f7aa2c6462c76be37b2,
title = "Altered NaCl concentration of airway surface liquid in cystic fibrosis",
abstract = "A novel isotopic technique suggests that the [Na] and [C1] of airway surface liquid are both normally ∼50 mM. In cystic fibrosis, lack of the functional cystic fibrosis transmembrane conductance regulator (CFTR) causes failure of transcellular C1 absorption, resulting in an elevation of [Na] and [C1] of airway surface liquid to ∼100 mM.",
keywords = "Active Na absorption, Airway surface liquid, Cystic fibrosis",
author = "Jonathan Widdicombe",
year = "2001",
doi = "10.1007/s004240100636",
language = "English (US)",
volume = "443",
journal = "Pflugers Archiv European Journal of Physiology",
issn = "0031-6768",
publisher = "Springer Verlag",
number = "SUPPL. 1",

}

TY - JOUR

T1 - Altered NaCl concentration of airway surface liquid in cystic fibrosis

AU - Widdicombe, Jonathan

PY - 2001

Y1 - 2001

N2 - A novel isotopic technique suggests that the [Na] and [C1] of airway surface liquid are both normally ∼50 mM. In cystic fibrosis, lack of the functional cystic fibrosis transmembrane conductance regulator (CFTR) causes failure of transcellular C1 absorption, resulting in an elevation of [Na] and [C1] of airway surface liquid to ∼100 mM.

AB - A novel isotopic technique suggests that the [Na] and [C1] of airway surface liquid are both normally ∼50 mM. In cystic fibrosis, lack of the functional cystic fibrosis transmembrane conductance regulator (CFTR) causes failure of transcellular C1 absorption, resulting in an elevation of [Na] and [C1] of airway surface liquid to ∼100 mM.

KW - Active Na absorption

KW - Airway surface liquid

KW - Cystic fibrosis

UR - http://www.scopus.com/inward/record.url?scp=0035178729&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035178729&partnerID=8YFLogxK

U2 - 10.1007/s004240100636

DO - 10.1007/s004240100636

M3 - Article

VL - 443

JO - Pflugers Archiv European Journal of Physiology

JF - Pflugers Archiv European Journal of Physiology

SN - 0031-6768

IS - SUPPL. 1

ER -