Altered NaCl concentration of airway surface liquid in cystic fibrosis

Jonathan Widdicombe

doi:10.1007/s004240100636

Altered NaCl concentration of airway surface liquid in cystic fibrosis

Jonathan Widdicombe

Physiology and Membrane Biology

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

A novel isotopic technique suggests that the [Na] and [C1] of airway surface liquid are both normally ∼50 mM. In cystic fibrosis, lack of the functional cystic fibrosis transmembrane conductance regulator (CFTR) causes failure of transcellular C1 absorption, resulting in an elevation of [Na] and [C1] of airway surface liquid to ∼100 mM.

Original language	English (US)
Journal	Pflugers Archiv European Journal of Physiology
Volume	443
Issue number	SUPPL. 1
DOIs	https://doi.org/10.1007/s004240100636
State	Published - 2001

Keywords

Active Na absorption
Airway surface liquid
Cystic fibrosis

ASJC Scopus subject areas

Physiology

Access to Document

10.1007/s004240100636

Fingerprint Dive into the research topics of 'Altered NaCl concentration of airway surface liquid in cystic fibrosis'. Together they form a unique fingerprint.

Cite this

@article{915a41de95354f7aa2c6462c76be37b2,

title = "Altered NaCl concentration of airway surface liquid in cystic fibrosis",

abstract = "A novel isotopic technique suggests that the [Na] and [C1] of airway surface liquid are both normally ∼50 mM. In cystic fibrosis, lack of the functional cystic fibrosis transmembrane conductance regulator (CFTR) causes failure of transcellular C1 absorption, resulting in an elevation of [Na] and [C1] of airway surface liquid to ∼100 mM.",

keywords = "Active Na absorption, Airway surface liquid, Cystic fibrosis",

author = "Jonathan Widdicombe",

year = "2001",

doi = "10.1007/s004240100636",

language = "English (US)",

volume = "443",

journal = "Pflugers Archiv European Journal of Physiology",

issn = "0031-6768",

publisher = "Springer Verlag",

number = "SUPPL. 1",

}

TY - JOUR

T1 - Altered NaCl concentration of airway surface liquid in cystic fibrosis

AU - Widdicombe, Jonathan

PY - 2001

Y1 - 2001

N2 - A novel isotopic technique suggests that the [Na] and [C1] of airway surface liquid are both normally ∼50 mM. In cystic fibrosis, lack of the functional cystic fibrosis transmembrane conductance regulator (CFTR) causes failure of transcellular C1 absorption, resulting in an elevation of [Na] and [C1] of airway surface liquid to ∼100 mM.

AB - A novel isotopic technique suggests that the [Na] and [C1] of airway surface liquid are both normally ∼50 mM. In cystic fibrosis, lack of the functional cystic fibrosis transmembrane conductance regulator (CFTR) causes failure of transcellular C1 absorption, resulting in an elevation of [Na] and [C1] of airway surface liquid to ∼100 mM.

KW - Active Na absorption

KW - Airway surface liquid

KW - Cystic fibrosis

UR - http://www.scopus.com/inward/record.url?scp=0035178729&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035178729&partnerID=8YFLogxK

U2 - 10.1007/s004240100636

DO - 10.1007/s004240100636

M3 - Article

C2 - 11845295

AN - SCOPUS:0035178729

VL - 443

JO - Pflugers Archiv European Journal of Physiology

JF - Pflugers Archiv European Journal of Physiology

SN - 0031-6768

IS - SUPPL. 1

ER -