TY - JOUR
T1 - Altered NaCl concentration of airway surface liquid in cystic fibrosis
AU - Widdicombe, Jonathan
PY - 2001
Y1 - 2001
N2 - A novel isotopic technique suggests that the [Na] and [C1] of airway surface liquid are both normally ∼50 mM. In cystic fibrosis, lack of the functional cystic fibrosis transmembrane conductance regulator (CFTR) causes failure of transcellular C1 absorption, resulting in an elevation of [Na] and [C1] of airway surface liquid to ∼100 mM.
AB - A novel isotopic technique suggests that the [Na] and [C1] of airway surface liquid are both normally ∼50 mM. In cystic fibrosis, lack of the functional cystic fibrosis transmembrane conductance regulator (CFTR) causes failure of transcellular C1 absorption, resulting in an elevation of [Na] and [C1] of airway surface liquid to ∼100 mM.
KW - Active Na absorption
KW - Airway surface liquid
KW - Cystic fibrosis
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U2 - 10.1007/s004240100636
DO - 10.1007/s004240100636
M3 - Article
C2 - 11845295
AN - SCOPUS:0035178729
VL - 443
JO - Pflugers Archiv fur die gesamte Physiologie des Menschen und der Tiere
JF - Pflugers Archiv fur die gesamte Physiologie des Menschen und der Tiere
SN - 0031-6768
IS - SUPPL. 1
ER -