Altered NaCl concentration of airway surface liquid in cystic fibrosis

Jonathan Widdicombe

Research output: Contribution to journal › Article

9 Citations (Scopus)

Abstract

A novel isotopic technique suggests that the [Na] and [C1] of airway surface liquid are both normally ∼50 mM. In cystic fibrosis, lack of the functional cystic fibrosis transmembrane conductance regulator (CFTR) causes failure of transcellular C1 absorption, resulting in an elevation of [Na] and [C1] of airway surface liquid to ∼100 mM.

Original languageEnglish (US)
JournalPflugers Archiv European Journal of Physiology
Volume443
Issue numberSUPPL. 1
DOIs
StatePublished - 2001

Fingerprint

Cystic Fibrosis Transmembrane Conductance Regulator
Cystic Fibrosis
Liquids

Keywords

  • Active Na absorption
  • Airway surface liquid
  • Cystic fibrosis

ASJC Scopus subject areas

  • Physiology

Cite this

Altered NaCl concentration of airway surface liquid in cystic fibrosis. / Widdicombe, Jonathan.

In: Pflugers Archiv European Journal of Physiology, Vol. 443, No. SUPPL. 1, 2001.

Research output: Contribution to journal › Article

Widdicombe, J 2001, 'Altered NaCl concentration of airway surface liquid in cystic fibrosis', Pflugers Archiv European Journal of Physiology, vol. 443, no. SUPPL. 1. https://doi.org/10.1007/s004240100636
Widdicombe J. Altered NaCl concentration of airway surface liquid in cystic fibrosis. Pflugers Archiv European Journal of Physiology. 2001;443(SUPPL. 1). https://doi.org/10.1007/s004240100636
Widdicombe, Jonathan. / Altered NaCl concentration of airway surface liquid in cystic fibrosis. In: Pflugers Archiv European Journal of Physiology. 2001 ; Vol. 443, No. SUPPL. 1.
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