Altered NaCl concentration of airway surface liquid in cystic fibrosis

Jonathan Widdicombe

doi:10.1007/s004240100636

Altered NaCl concentration of airway surface liquid in cystic fibrosis

Jonathan Widdicombe

Physiology and Membrane Biology

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

A novel isotopic technique suggests that the [Na] and [C1] of airway surface liquid are both normally ∼50 mM. In cystic fibrosis, lack of the functional cystic fibrosis transmembrane conductance regulator (CFTR) causes failure of transcellular C1 absorption, resulting in an elevation of [Na] and [C1] of airway surface liquid to ∼100 mM.

Original language	English (US)
Journal	Pflugers Archiv European Journal of Physiology
Volume	443
Issue number	SUPPL. 1
DOIs	https://doi.org/10.1007/s004240100636
State	Published - 2001

Keywords

Active Na absorption
Airway surface liquid
Cystic fibrosis

ASJC Scopus subject areas

Physiology

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10.1007/s004240100636

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title = "Altered NaCl concentration of airway surface liquid in cystic fibrosis",

abstract = "A novel isotopic technique suggests that the [Na] and [C1] of airway surface liquid are both normally ∼50 mM. In cystic fibrosis, lack of the functional cystic fibrosis transmembrane conductance regulator (CFTR) causes failure of transcellular C1 absorption, resulting in an elevation of [Na] and [C1] of airway surface liquid to ∼100 mM.",

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year = "2001",

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AB - A novel isotopic technique suggests that the [Na] and [C1] of airway surface liquid are both normally ∼50 mM. In cystic fibrosis, lack of the functional cystic fibrosis transmembrane conductance regulator (CFTR) causes failure of transcellular C1 absorption, resulting in an elevation of [Na] and [C1] of airway surface liquid to ∼100 mM.

KW - Active Na absorption

KW - Airway surface liquid

KW - Cystic fibrosis

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JO - Pflugers Archiv fur die gesamte Physiologie des Menschen und der Tiere

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ER -

Altered NaCl concentration of airway surface liquid in cystic fibrosis

Abstract

Keywords

ASJC Scopus subject areas

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