Altered NaCl concentration of airway surface liquid in cystic fibrosis

Research output: Contribution to journalArticle

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Abstract

A novel isotopic technique suggests that the [Na] and [C1] of airway surface liquid are both normally ∼50 mM. In cystic fibrosis, lack of the functional cystic fibrosis transmembrane conductance regulator (CFTR) causes failure of transcellular C1 absorption, resulting in an elevation of [Na] and [C1] of airway surface liquid to ∼100 mM.

Original languageEnglish (US)
JournalPflugers Archiv European Journal of Physiology
Volume443
Issue numberSUPPL. 1
DOIs
StatePublished - 2001

Keywords

  • Active Na absorption
  • Airway surface liquid
  • Cystic fibrosis

ASJC Scopus subject areas

  • Physiology

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