Altered N400 Congruity Effects in Parkinson's Disease without Dementia

Marta Kutas, Vicente J. Iragui, Yu Qiong Niu, Tanya J. D'Avanzo, Jin Chen Yang, David P. Salmon, Lin Zhang, John M Olichney

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Citations (Scopus)

Abstract

The N400 congruity effect (event-related brain potential (ERP) 300-500. ms poststimulus onset to contextually incongruent minus congruent words) generally shows a linear amplitude decrease with normal aging, and an even greater decrease in Alzheimer's dementia. As little is known about N400 effects in Parkinson's disease (PD), we recorded ERPs in 11 elderly patients with PD (without dementia, mean age. =. 66. years) during antonymic and category verification. Nondemented PD patients exhibited larger N400 congruity effects than their age-matched controls, consistent with reports of behavioral hyperpriming and possibly insufficient inhibition of irrelevant semantic information and/or greater target activation. It is also consistent with abnormally heavy reliance in PD on external cues. These findings implicate abnormal dopaminergic signaling (e.g., frontostriatal and/or mesocortical circuits) in PD, despite l-dopa therapy.

Original languageEnglish (US)
Title of host publicationCognitive Electrophysiology of Attention: Signals of the Mind
PublisherElsevier Inc.
Pages254-267
Number of pages14
ISBN (Print)9780123984517
DOIs
StatePublished - Oct 2013

Fingerprint

Parkinson Disease
Dementia
Dihydroxyphenylalanine
Evoked Potentials
Semantics
Cues
Alzheimer Disease
Brain
Therapeutics

Keywords

  • Dopamine
  • Executive dysfunction
  • N400
  • Parkinson
  • Semantic processing

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Kutas, M., Iragui, V. J., Niu, Y. Q., D'Avanzo, T. J., Yang, J. C., Salmon, D. P., ... Olichney, J. M. (2013). Altered N400 Congruity Effects in Parkinson's Disease without Dementia. In Cognitive Electrophysiology of Attention: Signals of the Mind (pp. 254-267). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-398451-7.00020-8

Altered N400 Congruity Effects in Parkinson's Disease without Dementia. / Kutas, Marta; Iragui, Vicente J.; Niu, Yu Qiong; D'Avanzo, Tanya J.; Yang, Jin Chen; Salmon, David P.; Zhang, Lin; Olichney, John M.

Cognitive Electrophysiology of Attention: Signals of the Mind. Elsevier Inc., 2013. p. 254-267.

Research output: Chapter in Book/Report/Conference proceedingChapter

Kutas, M, Iragui, VJ, Niu, YQ, D'Avanzo, TJ, Yang, JC, Salmon, DP, Zhang, L & Olichney, JM 2013, Altered N400 Congruity Effects in Parkinson's Disease without Dementia. in Cognitive Electrophysiology of Attention: Signals of the Mind. Elsevier Inc., pp. 254-267. https://doi.org/10.1016/B978-0-12-398451-7.00020-8
Kutas M, Iragui VJ, Niu YQ, D'Avanzo TJ, Yang JC, Salmon DP et al. Altered N400 Congruity Effects in Parkinson's Disease without Dementia. In Cognitive Electrophysiology of Attention: Signals of the Mind. Elsevier Inc. 2013. p. 254-267 https://doi.org/10.1016/B978-0-12-398451-7.00020-8
Kutas, Marta ; Iragui, Vicente J. ; Niu, Yu Qiong ; D'Avanzo, Tanya J. ; Yang, Jin Chen ; Salmon, David P. ; Zhang, Lin ; Olichney, John M. / Altered N400 Congruity Effects in Parkinson's Disease without Dementia. Cognitive Electrophysiology of Attention: Signals of the Mind. Elsevier Inc., 2013. pp. 254-267
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