This review focuses on the (mal)adaptive processes in atrial excitation-contraction coupling occurring in patients with chronic atrial fibrillation. Cellular remodeling includes shortening of the atrial action potential duration and effective refractory period, depressed intracellular Ca 2+ transient, and reduced myocyte contractility. Here we summarize the current knowledge of the ionic bases underlying these changes. Understanding the molecular mechanisms of excitation-contraction-coupling remodeling in the fibrillating human atria is important to identify new potential targets for AF therapy.
|Original language||English (US)|
|Journal||Journal of Atrial Fibrillation|
|State||Published - Apr 1 2012|
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine