Altered excitation-contraction coupling in human chronic atrial fibrillation

Eleonora Grandi, Antony J. Workman, Sandeep V. Pandit

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

This review focuses on the (mal)adaptive processes in atrial excitation-contraction coupling occurring in patients with chronic atrial fibrillation. Cellular remodeling includes shortening of the atrial action potential duration and effective refractory period, depressed intracellular Ca 2+ transient, and reduced myocyte contractility. Here we summarize the current knowledge of the ionic bases underlying these changes. Understanding the molecular mechanisms of excitation-contraction-coupling remodeling in the fibrillating human atria is important to identify new potential targets for AF therapy.

Original languageEnglish (US)
JournalJournal of Atrial Fibrillation
Volume2
Issue number10
StatePublished - Apr 1 2012

Fingerprint

Excitation Contraction Coupling
Atrial Fibrillation
Knowledge Bases
Muscle Cells
Action Potentials
Therapeutics

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Altered excitation-contraction coupling in human chronic atrial fibrillation. / Grandi, Eleonora; Workman, Antony J.; Pandit, Sandeep V.

In: Journal of Atrial Fibrillation, Vol. 2, No. 10, 01.04.2012.

Research output: Contribution to journalReview article

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