Altered brain activity in women recovered from bulimic-type eating disorders after a glucose challenge: A pilot study

Guido K. Frank, Angela Wagner, Sarah Achenbach, Claire McConaha, Kellie Skovira, Howard Aizenstein, Cameron S Carter, Walter H. Kaye

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

Objective: It is not known whether individuals with bulimic-type eating disorders have a dysregulation of brain pathways that modulate appetite. Taste plays a role in the regulation of appetite and the purpose of the current study was to determine whether bulimic women have alterations in the physiologic response to the blind administration of glucose. Method: To avoid the confounding effects of a current eating disorder, and to assess possibly trait-related disturbances, we studied 10 subjects recovered (≥1 year) from a bulimic-type eating disorder and 6 control women. Subjects were administered a solution of glucose or artificial saliva (control solution) in alternating blocks during a functional magnet resonance imaging scan. Results: Individuals who recovered from a bulimic-type eating disorder had significantly lower activation in the right anterior cingulate cortex (ACC; Montreal Neurological Institute [MNI] coordinates x = 8, y = 22, z = 28; cluster size = 18 voxels, T = 5.11, Z-score = 3.78) and in the left cuneus (occipital cortex; MNI coordinates x = -12, y = -78, z = 10; cluster size = 21 voxels, T = 4.27, Z-score = 3.36), when glucose was compared with artificial saliva. Conclusion: The ACC plays a role in the anticipation of reward. Individuals with bulimic-type eating disorders may have a reduced reward response to nutrients, and thus may be vulnerable to overeating. However, this is a small sample and the current study will need replication in a larger sample size with investigation of additional regions of interest.

Original languageEnglish (US)
Pages (from-to)76-79
Number of pages4
JournalInternational Journal of Eating Disorders
Volume39
Issue number1
DOIs
StatePublished - Jan 2006

Fingerprint

eating disorders
brain
Glucose
glucose
Artificial Saliva
Brain
Occipital Lobe
appetite
saliva
Reward
cortex
Appetite Regulation
Hyperphagia
overeating
Magnets
Gyrus Cinguli
Appetite
Sample Size
Feeding and Eating Disorders
image analysis

Keywords

  • Appetite
  • Brain pathways
  • Bulimic-type eating disorder
  • Overeating

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Psychiatry and Mental health
  • Food Science
  • Psychology(all)
  • Clinical Psychology

Cite this

Altered brain activity in women recovered from bulimic-type eating disorders after a glucose challenge : A pilot study. / Frank, Guido K.; Wagner, Angela; Achenbach, Sarah; McConaha, Claire; Skovira, Kellie; Aizenstein, Howard; Carter, Cameron S; Kaye, Walter H.

In: International Journal of Eating Disorders, Vol. 39, No. 1, 01.2006, p. 76-79.

Research output: Contribution to journalArticle

Frank, Guido K. ; Wagner, Angela ; Achenbach, Sarah ; McConaha, Claire ; Skovira, Kellie ; Aizenstein, Howard ; Carter, Cameron S ; Kaye, Walter H. / Altered brain activity in women recovered from bulimic-type eating disorders after a glucose challenge : A pilot study. In: International Journal of Eating Disorders. 2006 ; Vol. 39, No. 1. pp. 76-79.
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