Abstract
Aim: To test the hypotheses that body size is reduced and body composition altered in preterm infants at hospital discharge. Methods: Preterm infants (≤34 weeks gestation, ≤1750 g at birth) were enrolled. Body weight, length and head circumference were converted to standard deviation or z-scores. Body composition was measured using dual emission X-ray absorptiometry. The results were analysed using standard statistics. Results: One hundred and forty-nine infants (birth weight = 1406 ± 248 g, gestation = 31 ± 1.7 weeks) were studied. Postmenstrual age at discharge was 37 ± 1.2 weeks. Z-scores for head circumference, weight and length differed (-0.1 ± 0.6 > -1.4 ± 0.6 > -1.9 ± 0.6; p < 0.0001). Global fat-free mass was less in study infants than the reference infant at the same weight (2062 < 2252 g; p < 0.0001) or gestation (2062 < 2667 g; p < 0.0001). Global fat mass was greater in study infants than the reference infant at the same weight (307 > 198 g, 13 > 8%) or gestation (307 > 273 g; 13 > 9%; p < 0.0001). Changes in central fat mass closely paralleled those in global fat mass (r2 = 0.76, p < 0.0001). Conclusion: Reduced linear growth and a reduced fat-free mass suggest that dietary protein needs were not met before discharge. A reduced fat-free mass coupled with an increased global and central fat mass echoes concerns about the development of insulin resistance and metabolic syndrome X in these high-risk infants.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1269-1273 |
| Number of pages | 5 |
| Journal | Acta Paediatrica, International Journal of Paediatrics |
| Volume | 98 |
| Issue number | 8 |
| DOIs | |
| State | Published - Aug 2009 |
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Keywords
- Body composition
- Preterm infants
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
Cite this
Altered body composition in preterm infants at hospital discharge. / Cooke, Richard J.; Griffin, Ian.
In: Acta Paediatrica, International Journal of Paediatrics, Vol. 98, No. 8, 08.2009, p. 1269-1273.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Altered body composition in preterm infants at hospital discharge
AU - Cooke, Richard J.
AU - Griffin, Ian
PY - 2009/8
Y1 - 2009/8
N2 - Aim: To test the hypotheses that body size is reduced and body composition altered in preterm infants at hospital discharge. Methods: Preterm infants (≤34 weeks gestation, ≤1750 g at birth) were enrolled. Body weight, length and head circumference were converted to standard deviation or z-scores. Body composition was measured using dual emission X-ray absorptiometry. The results were analysed using standard statistics. Results: One hundred and forty-nine infants (birth weight = 1406 ± 248 g, gestation = 31 ± 1.7 weeks) were studied. Postmenstrual age at discharge was 37 ± 1.2 weeks. Z-scores for head circumference, weight and length differed (-0.1 ± 0.6 > -1.4 ± 0.6 > -1.9 ± 0.6; p < 0.0001). Global fat-free mass was less in study infants than the reference infant at the same weight (2062 < 2252 g; p < 0.0001) or gestation (2062 < 2667 g; p < 0.0001). Global fat mass was greater in study infants than the reference infant at the same weight (307 > 198 g, 13 > 8%) or gestation (307 > 273 g; 13 > 9%; p < 0.0001). Changes in central fat mass closely paralleled those in global fat mass (r2 = 0.76, p < 0.0001). Conclusion: Reduced linear growth and a reduced fat-free mass suggest that dietary protein needs were not met before discharge. A reduced fat-free mass coupled with an increased global and central fat mass echoes concerns about the development of insulin resistance and metabolic syndrome X in these high-risk infants.
AB - Aim: To test the hypotheses that body size is reduced and body composition altered in preterm infants at hospital discharge. Methods: Preterm infants (≤34 weeks gestation, ≤1750 g at birth) were enrolled. Body weight, length and head circumference were converted to standard deviation or z-scores. Body composition was measured using dual emission X-ray absorptiometry. The results were analysed using standard statistics. Results: One hundred and forty-nine infants (birth weight = 1406 ± 248 g, gestation = 31 ± 1.7 weeks) were studied. Postmenstrual age at discharge was 37 ± 1.2 weeks. Z-scores for head circumference, weight and length differed (-0.1 ± 0.6 > -1.4 ± 0.6 > -1.9 ± 0.6; p < 0.0001). Global fat-free mass was less in study infants than the reference infant at the same weight (2062 < 2252 g; p < 0.0001) or gestation (2062 < 2667 g; p < 0.0001). Global fat mass was greater in study infants than the reference infant at the same weight (307 > 198 g, 13 > 8%) or gestation (307 > 273 g; 13 > 9%; p < 0.0001). Changes in central fat mass closely paralleled those in global fat mass (r2 = 0.76, p < 0.0001). Conclusion: Reduced linear growth and a reduced fat-free mass suggest that dietary protein needs were not met before discharge. A reduced fat-free mass coupled with an increased global and central fat mass echoes concerns about the development of insulin resistance and metabolic syndrome X in these high-risk infants.
KW - Body composition
KW - Preterm infants
UR - http://www.scopus.com/inward/record.url?scp=68249124389&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=68249124389&partnerID=8YFLogxK
U2 - 10.1111/j.1651-2227.2009.01354.x
DO - 10.1111/j.1651-2227.2009.01354.x
M3 - Article
C2 - 19594474
AN - SCOPUS:68249124389
VL - 98
SP - 1269
EP - 1273
JO - Acta Paediatrica, International Journal of Paediatrics
JF - Acta Paediatrica, International Journal of Paediatrics
SN - 0803-5253
IS - 8
ER -