Alteration of viral respiratory infections of mice by prior infection with mouse hepatitis virus.

V. A. Carrano, Stephen W Barthold, D. S. Beck, A. L. Smith

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Pre-infection with mouse hepatitis virus (MHV) strains S, 3, or JHM reduced the ability of mice to seroconvert to PVM. Geometric mean antibody titers to PVM among MHV pre-infected mice were lower than those for control mice given only PVM, and dually infected mice seroconverted to PVM later than mice given PVM alone. PVM was not recovered from normally permissive respiratory tract tissues of MHV-S pre-infected mice. Pre-infection of DBA/2 mice with MHV-S compromised the susceptibility of these mice to lethal Sendai virus infection but did not substantially reduce the titers of infectious Sendai virus recovered from the lungs. Serologic responses to Sendai virus and lung Sendai virus titers were similar in Sendai virus-resistant C57BL/6 mice pre-infected or not with MHV-S.

Original languageEnglish (US)
Pages (from-to)573-576
Number of pages4
JournalLaboratory animal science Chicago
Volume34
Issue number6
StatePublished - Dec 1984
Externally publishedYes

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

Fingerprint Dive into the research topics of 'Alteration of viral respiratory infections of mice by prior infection with mouse hepatitis virus.'. Together they form a unique fingerprint.

  • Cite this