Abstract
Myocardial failure in dilated cardiomyopathy may result from subcellular alterations in contractile protein function, excitation-contraction coupling processes, or recovery metabolism. We used isometric force and heat measurements to quantitatively investigate these subcellular systems in intact left ventricular muscle strips from nonfailing human hearts (n=14) and from hearts with end-stage failing dilated cardiomyopathy (n=13). In the failing myocardium, peak isometric twitch tension, maximum rate of tension rise, and maximum rate of relaxation were reduced by 46% (p=0.013), 51% (p=0.003), and 46% (p=0.018), respectively (37°C, 60 beats per minute). Tension-dependent heat, reflecting the number of crossbridge interactions during the isometric twitch, was reduced by 61% in the failing myocardium (p=0.006). In terms of the individual crossbridge cycle, the average crossbridge force-time integral was increased by 33% (p=0.04) in the failing myocardium. In the nonfailing myocardium, the crossbridge force-time integral was positively correlated with the patient's age (r=0.86, p
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1225-1232 |
| Number of pages | 8 |
| Journal | Circulation Research |
| Volume | 70 |
| Issue number | 6 |
| State | Published - 1992 |
| Externally published | Yes |
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Keywords
- calcium cycling
- crossbridges
- dilated cardiomyopathy myocardial failure
- human myocardium
ASJC Scopus subject areas
- Physiology
- Cardiology and Cardiovascular Medicine
Cite this
Alteration of contractile function and excitation-contraction coupling in dilated cardiomyopathy. / Hasenfuss, G. P.; Mulieri, L. A.; Leavitt, B. J.; Allen, P. D.; Haeberle, J. R.; Alpert, N. R.
In: Circulation Research, Vol. 70, No. 6, 1992, p. 1225-1232.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Alteration of contractile function and excitation-contraction coupling in dilated cardiomyopathy
AU - Hasenfuss, G. P.
AU - Mulieri, L. A.
AU - Leavitt, B. J.
AU - Allen, P. D.
AU - Haeberle, J. R.
AU - Alpert, N. R.
PY - 1992
Y1 - 1992
N2 - Myocardial failure in dilated cardiomyopathy may result from subcellular alterations in contractile protein function, excitation-contraction coupling processes, or recovery metabolism. We used isometric force and heat measurements to quantitatively investigate these subcellular systems in intact left ventricular muscle strips from nonfailing human hearts (n=14) and from hearts with end-stage failing dilated cardiomyopathy (n=13). In the failing myocardium, peak isometric twitch tension, maximum rate of tension rise, and maximum rate of relaxation were reduced by 46% (p=0.013), 51% (p=0.003), and 46% (p=0.018), respectively (37°C, 60 beats per minute). Tension-dependent heat, reflecting the number of crossbridge interactions during the isometric twitch, was reduced by 61% in the failing myocardium (p=0.006). In terms of the individual crossbridge cycle, the average crossbridge force-time integral was increased by 33% (p=0.04) in the failing myocardium. In the nonfailing myocardium, the crossbridge force-time integral was positively correlated with the patient's age (r=0.86, p
AB - Myocardial failure in dilated cardiomyopathy may result from subcellular alterations in contractile protein function, excitation-contraction coupling processes, or recovery metabolism. We used isometric force and heat measurements to quantitatively investigate these subcellular systems in intact left ventricular muscle strips from nonfailing human hearts (n=14) and from hearts with end-stage failing dilated cardiomyopathy (n=13). In the failing myocardium, peak isometric twitch tension, maximum rate of tension rise, and maximum rate of relaxation were reduced by 46% (p=0.013), 51% (p=0.003), and 46% (p=0.018), respectively (37°C, 60 beats per minute). Tension-dependent heat, reflecting the number of crossbridge interactions during the isometric twitch, was reduced by 61% in the failing myocardium (p=0.006). In terms of the individual crossbridge cycle, the average crossbridge force-time integral was increased by 33% (p=0.04) in the failing myocardium. In the nonfailing myocardium, the crossbridge force-time integral was positively correlated with the patient's age (r=0.86, p
KW - calcium cycling
KW - crossbridges
KW - dilated cardiomyopathy myocardial failure
KW - human myocardium
UR - http://www.scopus.com/inward/record.url?scp=0026551226&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026551226&partnerID=8YFLogxK
M3 - Article
VL - 70
SP - 1225
EP - 1232
JO - Circulation Research
JF - Circulation Research
SN - 0009-7330
IS - 6
ER -